Structure-based discovery of inhibitors of microsomal prostaglandin E 2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: Promising hits for the development of new anti-inflammatory agents

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1565-1575

  De Simone, Rosa ^a   Chini, Maria Giovanna ^a   Bruno, Ines ^a   Riccio, Raffaele ^a   Mueller, Daniela ^b   Werz, Oliver ^b   Bifulco, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; PROSTAGLANDIN E2 SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CYCLOADDITION; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR DOCKING;

5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS; 5-LIPOXYGENASE-ACTIVATING PROTEINS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CATALYTIC DOMAIN; CELL LINE, TUMOR; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOXYGENASE INHIBITORS; MICROSOMES; MODELS, MOLECULAR; NEUTROPHILS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79952788439     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101238d     Document Type: Article

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