Location of inhibitor binding sites in the human inducible prostaglandin e synthase, MPGES1

Biochemistry

Volumn 50, Issue 35, 2011, Pages 7684-7693

  Prage, Edward B ^a   Pawelzik, Sven Christian ^b   Busenlehner, Laura S ^a   Kim, Kwangho ^a   Morgenstern, Ralf ^b   Jakobsson, Per Johan ^b   Armstrong, Richard N ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COEXPRESSED; CYCLOOXYGENASE 2; GLUTATHIONES; H/D EXCHANGE; INTEGRAL MEMBRANE PROTEINS; MICROSOMAL PROSTAGLANDIN; MPGES-1; PHYSICAL EVIDENCE; PROSTAGLANDINE; SPECIFIC INHIBITORS; SYNTHASES; THREE-DIMENSIONAL CRYSTALS; TRANSMEMBRANE HELICES;

AMIDES; BIOLOGICAL MEMBRANES; ENZYME INHIBITION; HYDROPHOBICITY; MASS SPECTROMETRY; OLIGOMERS; PROTEINS;

BINDING SITES;

GLUTATHIONE; INDUCIBLE MICROSOMAL PROSTAGLANDIN E2 SYNTHASE; PROSTAGLANDIN E SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HYDROPHOBICITY; IC 50; MASS SPECTROMETRY; PRIORITY JOURNAL;

BINDING SITES; CYCLOOXYGENASE INHIBITORS; GLUTATHIONE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRAMOLECULAR OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 80052242013     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2010448     Document Type: Article

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