Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1

Journal of Biological Chemistry

Volumn 285, Issue 38, 2010, Pages 29254-29261

  Pawelzik, Sven Christian ^a   Uda, Narasimha Rao ^a   Spahiu, Linda ^b,c   Jegerschöld, Caroline ^d   Stenberg, Patric ^b,c   Hebert, Hans ^d   Morgenstern, Ralf ^a   Jakobsson, Per Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Actar AB   (Sweden)

^c Nova SAID AB   (Sweden)

^d ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYME INHIBITION; PHOSPHOLIPIDS;

ACTIVE SITE; BASAL LEVELS; CONVENTIONAL DRUGS; CYCLOOXYGENASES; INFLAMMATORY REACTION; INHIBITOR ACTIVITY; MICROSOMAL PROSTAGLANDIN; MPGES-1; NATURAL SUBSTRATES; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; PHOSPHOLIPID BILAYER; PROINFLAMMATORY CYTOKINES; PROSTAGLANDINE; SYNTHASES; TRANSMEMBRANE HELICES;

ENZYMES;

1 C (2 CHLOROBENZENE) 3 N (NAPHTALEN 1 YL)BENZENE 1,3 DICARBOXAMIDE; 4 [2 (3 BROMOPHENYL)HYDRAZIN 1 YLIDENE] 1 ETHANETHIONYL 3 METHYL 4,5 DIHYDRO 1H PYRAZOL 5 ONE; ALANINE; CHIMERIC PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; ENZYME INHIBITOR; LEUCINE; MEMBRANE PROTEIN; MICROSOME ENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; PROSTAGLANDIN E2; PROSTAGLANDIN H2; PROTEIN SUBUNIT; THREONINE; UNCLASSIFIED DRUG; ISOMERASE; PROSTAGLANDIN E SYNTHASE; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; INFLAMMATION; ORTHOLOGY; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SPECIES DIFFERENCE; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IC50; IMMUNOBLOTTING; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

RATTUS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; ENZYME INHIBITORS; HUMANS; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 77956523191     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.114454     Document Type: Article

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