The anti-tumorigenic mushroom agaricus blazei murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Huang, Tsung Teng ^a,b   Ojcius, David M ^a,c   Young, John D ^a,d,e   Wu, Yi Hui ^f   Ko, Yun Fei ^e   Wong, Tsui Yin ^a   Wu, Cheng Yeu ^a   Lu, Chia Chen ^g   Lai, Hsin Chih ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e MING CHI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^g FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGARICUS BLAZEI EXTRACT; CATHEPSIN B; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; POTASSIUM ION; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MACROPHAGE; PHAGOCYTOSIS; POTASSIUM TRANSPORT; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATE; AGARICUS; ANTICARCINOGENIC AGENTS; CARRIER PROTEINS; CASPASE 1; CATHEPSIN B; CELL LINE, TUMOR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; PLANT EXTRACTS; POTASSIUM; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2X7;

AGARICUS BLAZEI; BASIDIOMYCOTA;

EID: 84864186420     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041383     Document Type: Article

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