Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis

Cancer Immunology Immunotherapy

Volumn 46, Issue 3, 1998, Pages 147-159

  Fujimiya, Yoshiaki ^a,b   Suzuki, Youichi ^a   Oshiman, Ko Ichi ^b   Kobori, Hidekazu ^b   Moriguchi, Koichi ^c   Nakashima, Hisako ^c   Matumoto, Yonezo ^c   Takahara, Shogo ^b   Ebina, Takusaburo ^a   Katakura, Ryuichi ^a  

^a MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Sumitomo Forestry Co Ltd   (Japan)

^c Sumika Chemicals Analysis Service Ltd   (Japan)

Author keywords

Glucan; Agaricus; Apoptosis; Natural killer cells

Indexed keywords

ANTIGEN; DNA FRAGMENT; PROTEOGLYCAN;

AGARICALES; ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BASIDIOMYCETES; CANCER INHIBITION; CELL ACTIVATION; CELL CYCLE; CHROMATOFOCUSING; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPHORESIS; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; INTRATHECAL DRUG ADMINISTRATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TUMOR;

AGARICUS; ANIMALS; ANTIGENS, SURFACE; APOPTOSIS; CARCINOGENS; CELL CYCLE; CHROMATOGRAPHY; CYTOTOXICITY, IMMUNOLOGIC; DNA FRAGMENTATION; FUNGAL PROTEINS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEMBRANE PROTEINS; METHYLCHOLANTHRENE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHENOTYPE; PROTEOGLYCANS; SPLEEN; TRANSPLANTS; TUMOR CELLS, CULTURED;

EID: 7144256246     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050473     Document Type: Article

References (30)

1. Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J, Fiers W (1986) Human tumor xenografts treated with recombinant human necrosis factor alone or in combination with interferons. Cancer Res 46:3990
2. Chihara G, Maeda Y (1982) Antitumor polysaccharide lentinan and serum protein components. In Periti P, Grassi GG (eds) Current chemotherapy and immunotherapy. American Society for Microbiology, Philadelphia, p 1187
3. Doita M, Rasmussen L-T, Seljelid R, Lipsky PE (1991) Effect of soluble animated β-1,3-D-polyglucose on human monocytes: stimulation of cytokine and prostaglandin E2 production but not antigen-presenting function. J Leukoc Biol 49:342
4. Dubos M, Giles KA, Hamilton JK, Rebers PA, Smith F (1956) Colorimetric method for determination of sugars and related substances. Anal Chem 28:350
5. Ebina T, Kohya H, Yamaguchi T, Ishida N (1986) Antimetastatic effect of biological response modifiers in the "double-grafted tumor system". Jpn J Cancer Res 77:1034
6. Ebina T, Murata K, Tamura K (1994) Antitumor effect of intratumoral administration of biological response modifiers: induction of immunosuppressive acidic protein, a type of α1-acid glycoprotein, in mice. Jpn J Cancer Res 85:93
7. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493
8. Hamuro J, Rollinghoff M, Wagner H (1980) Induction of cytotoxic peritoneal exudate cells by T-cell immune adjuvants of the β(1, 3) glucan-type lentinan and its analogues. Immunology 39:551
9. Hrmova M, Harvey AJ, Wang J, Shirley NJ, Jones GP, Stones BA, Høj PB, Fincher GB (1996) Barley β-D-glucan exhydrolases with β-D-glucosidase activity. J Biol Chem 271:5277
10. Ito H, Ito H, Amano H, Noda H (1994) Inhibitory action of (1 →6)-β-glucan-protein complex (FIII-2-b) isolated from Agaricus blazei Murill ("Himematsutake") on MethA fibrosarcoma-bearing mice and its antitumor mechanism. Jpn J Pharmacol 66:265
11. Kawagishi H, Kanao T, Inagaki R, Mizuno T, Shimura K, Ito H, Hagiwara, T, Nakamura T (1990) Formolysis of a potent antitumor (1→6)-β-D-glucan-protein complex from Agaricus blazei fruiting bodies and antitumor activity of the resulting products. Carbohydr Polym 12:393
12. Kino K, Yamashita A, Yamaoka K, Watanabe J, Tanaka S, Ko K, Shimizu K, Tsunoo H (1989) Isolation, and characterization of a new immunomodulatory protein. Ling Zhi (LZ-8), from Canoderma lucidium. J Biol Chem 264:472
13. Kitamura S, Hori T, Kurita K, Takeo K, Hara C, Itoh W, Tabata K, Elgsater A, Stokke BT (1994) An antitumor, branched (1→3)-β-D-glucan from a water extract of fruiting bodies of Cryproporus vovatus. Carbohydr Res 263:111
14. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265
15. Mizuno T, Hagiwara T, Nakamura T, Ito H, Shimura K, Sumiya T, Asakura A (1990) Antitumor activity and some properties of water-soluble polysaccharides from "Himematsulake", the fruiting body of Agaricus blazei Murill. Agric Biol Chem 54:2889
16. Olson EJ, Standing JE, Griego-Harper N, Hoffman OA, Limper A (1996) Fungal β-glucan interacts with vitronectin and stimulates tumor necrosis factor alpha release from macrophages. Inf Immun 64:3548
17. Pretus HA, Ensley HE, McNamee RB, Jones EL, Browder IW, Williams D-L (1991) Isolation, physicochemical characterization and preclinical efficacy evaluation of soluble scleroglucan. J Pharm Exp Ther 257:500
18. Renzo LD, Yefeni E, Klein E (1991) The function of human NK cells is enhanced by β-glucan, a ligand of CR3 (CD11b/CD18). Eur J Immunol 21:1755
19. Riccardi C, Pucetti P, Santori A, Herberman RB (1979) Rapid "in vivo" assay of mouse natural killer cell activity. J Natl Cancer Inst 63:1041
20. Seljelid R, Bøgwald J, Hoffman J, Larm O (1984) A soluble β-1,3-D-glucan derivative potentiates the cytostatic and cytolytic capacity of mouse peritoneal macrophages in vitro. Immunopharmacology 7:69
21. Seljelid R, Figenschau Y, Bøgwald J, Rasmussen LT, Austgulen R (1989) Evidence that tumour necrosis factor induced by aminated β1-3D polyglucose is mediated by a concerted action of local and systemic cytokines. Scand J Immunol 30:687
22. Sherwood ER, Williams DL, McNamee RB, Vones EL, Browder IW, Di Lozio NR (1988) Soluble glucan and lymphokine-activated killer (LAK) cells in the therapy of experimental hepatic metastases. J Biol Response Mod 7:185
23. Soiffer RJ, Nurray C, Shapiro C, Collins H, Chartier S, Lago S, Ritz J (1996) Expansion and manipulation of natural killer cells in patients with metastatic cancer by low-dose continuous infusion and intermittent bolus administration of interleukin-2. Clin Cancer Res 2:493
24. Suda M, Ohno N, Adachi Y, Yadomae T (1994) Relationship between the tissue distribution and antitumor activity of highly branched (1→3)-β-D-glucan. SSG. Biol Pharm Bull 17:131
25. Sugarman BJ, Aggarwal BB, Hass PE, Figari P, Palladino M, Shepard HM (1985) Recombinant human tumor necrosis factor-α: effects on proliferation of normal and transformed cells. Science 230:943
26. Tsuchiya Y, Yang Z-B, Nakahashi S, Araki T (1993) Acceleration of natural killer cell recovery by a glucan, sizofiran, in anti-asialo GM1 antibody-treated mice. Int J Immunopharmacol 15:783
27. Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K (1984) Krestin (PSK). Cancer Treat Rev 11:131
28. Williams DL, Sherwood ER, McNamee RB, Vones EL, Browder IE, DiLuzio NR (1987) Chemoimmunotherapy of experimental hepatic metastases. Hepatology 7:1296
29. Wyllie AH, Morris RG, Smith AL, Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular sysnthesis. J Pathol 142:67
30. Zhang C, Ao Z, Seth A, Schlossman SF (1996) A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. J Immunol 157:3980