An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro

Inflammation

Volumn 29, Issue 4-6, 2005, Pages 147-153

  Bernardshaw, Soosaipillai ^a,c   Hetland, Geir ^a   Ellertsen, Linda Kathrine ^b   Tryggestad, Anne Merete Aaland ^a   Johnson, Egil ^a,c  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Agaricus blazei Murill; Monocytes and endothelial cells; Pro inflammmatory cytokines

Indexed keywords

AGARICUS BLAZEI EXTRACT; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

AGARICUS BLAZEI; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE ACTIVATION; MONOCYTE; MONONUCLEAR CELL; MUSHROOM; PHAGOCYTE; TH1 CELL; VASCULAR ENDOTHELIUM;

AGARICUS; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTERLEUKIN-12; MONOCYTES; PLANT EXTRACTS; UMBILICAL VEINS;

AGARICUS BLAZEI; BASIDIOMYCOTA;

EID: 33845430516     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-006-9010-2     Document Type: Article

References (33)

1. Huang, N. L. 1997. Brazilian mushroom (Gee Song Rong). In: Cultivation of eight rare and precious gourmet mushrooms. Chinese Agriculture University Press, Huang Edit, pp. 95-101.
2. Wasser, S. P., and A. L. Weis. 1999. Therapeutic effects of substances occuring in higher Basidiomycetes mushrooms: a modern perspective. Review. Crit. Rev. Immunol. 19:65-96.
3. Jong, S. C., and R. Donovick. 1989. Antitumour and antiviral substances from fungi. Adv. Appl. Microbiol. 34:183-262.
4. Kawagashi, H., R. Inagaki, T. Kanao, T. Mizuno, K. Shimura, H. Itoh, T. Hagiwara, and T. Nakamura. 1989. Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies. Carbohydr. Res. 186:267-273.
5. Itoh, H., H. Ito, H. Amano, and H. Noda. 1994. Inhibitory action of a (1→6)-β-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("Himematsutake") on meth A fibrosarcoma-bearing mice and its antitumor mechanism. Jpn. J. Pharmacol. 66:265-271.
6. Ebina, T., and Y. Fujimiya. 1998. Antitumor effect of a peptideglucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy. 11:259-265.
7. Ohno, N., M. Furukawa, N. N. Miura, Y. Adachi, M. Motoi, and Y. Yadomae. 2001. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol. Pharm. Bull. 7:820-828.
8. Fujimiya, Y., Y. Suzuki, Ko-ichi Oshiman, H. Kobori, K. Moriguchi, H. Nakashima, Y. Matumoto, S. Takahara, T. Ebina, and R. Katakura. 1998. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol. Immunother. 46:147-159.
9. Sorimachi, K., K. Akimoto, Y. Ikehara, K. Inafuku, A. Okubo, and S. Yamazaki. 2001. Secretion of TNF-α, IL-8 and nitrite oxide by macrohages activated with Agaricus blazei Murill fractions in vitro. Cell Struct. Funct. 26:103-108.
10. Kuo, Yuh-Chi, Yu-Ling Huang, Chieh-Chih Chen, YZ-Sheng Lin, Kai-An Chuang, and Wei-Jern Tsai. 2002. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J. Lab. Clin. Med. 140:176-187.
11. Riggi, S. J., and N. R. Di Luzio. 1961. Identification of a reticuloendothelial stimulating agent in zymosan. Am. J. Physiol. 200:297-300
12. Bøgwald, J., I. Gouda, J. Hoffmann, O. Larm, R. Larsson, and R. Seljelid. 1984. Stimulatory effect of immobilized glucans on macrophages in vitro. Scand. J. Immunol. 20:355-360.
13. Reynolds, J. A., M. D. Kastello, D. G. Harrington, et al. 1980. Glucan-induced enhancement of host resistance to selected infectious diseases. Infect. Immun. 30:51-57.
14. Hetland, G., M. Løvik, and H. G. Wiker. 1998. Protective effect of β-glucan against Mycobacterium bovis, BCG infection in Balb/c mice. Scand. J. Immunol. 47:548-553.
15. Hetland, G., N. Ohno, I. S. Aaberge, and M. Løvik. 2000. Protective effect of β-glucan against systemic Streptococcus pneumonia infection in mice. FEMS Immunol. Med. Microbiol. 27:111-116.
16. Bernardshaw, S., E. Johnson, and G. Hetland. 2005. An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice. Scand. J. Immunol. 62:393-398.
17. Langeggen, H., E. Namork, E. Johnson, and G. Hetland. 2003. HUVEC take up opsonized zymosan particles and secrete cytokines IL-6 and IL-8 in vitro. FEMS Immunol. Med. Microbiol. 36:55-61.
18. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukoc. Biol. 59:505-511.
19. Haddad, J. J. 2002. Cytokines and related receptor-mediated signaling pathways. Biohem. Biophys. Res. Commun. 297:700-713.
20. + regulatory T cell subsets. J. Leukoc. Biol. 74:471-478.
21. Bøyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Lab. Invest. 21(Suppl 97):77-89.
22. Kaplan, G., and G. Gaudernack. 1982. In vitro differentiation of human monocytes. Difference in monocytic phenotypes induced by cultivation on glass or on collagen. J. Exp. Med. 156:1001-1014.
23. Jaffe, E. A., R. L. Nachman, C. G. Becker, and C. R. Minick. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphological and immunological criteria. J. Clin. Lab. Invest. 52:2745-2756.
24. Ellertsen, L. K., G. Hetland, and E. Johnson. 2006. Effect of a medical extract from Agaricus blazei Murill on gene expression in human monocytes. Int. Immunopharmacol. 6:133-143.
25. Chihara, G. 1992. Immunopharmacology of Lentinan, a polysaccharide isolated from Lentinus edodes: its applications as a host defense potentiator. Int. J. Orient. Med. 17:57-77.
26. 2 production but not antigen-presenting function. J. Leukoc. Biol. 49:342-351.
27. Shimizu, S., H. Kitada, H. Yokota, J. Yamakawa, T. Murayama, K. Sugyama, H. Izumi, and N. Yamaguchi. 2002. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomed. 9:536-545.
28. Brown, G. D., P. R. Taylor, D. M. Reid, J. A. Willment, D. L. Williams, L. Martinez-Pomares, S. Y. C. Wong, and S. Gordon. 2002. Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196:407-412.
29. Langeggen, H., K. E. Berge, E. Johnson, and G. Hetland. 2002. Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro. Inflammation. 26:103-110.
30. Johnson, E., and G. Hetland. 1991. Human umbilical vein endothelial cells synthesize functional C3, C5, C6, C8 and C9 in vitro. Scand. J. Immunol. 33:667-671.
31. Johnson, E., and G. Hetland. 1988. Mononuclear phagocytes have the potential to synthesize the complete functional complement system. Scand. J. Immunol. 27:489-493.
32. Cavaillon, J. M. 1994. Cytokines and macrophages. Biomed. Pharmacother. 48:445-453.
33. Lienenlüke, B., T. Germann, R. A. Kroczek, and M. Hecker. 2000. CD154 stimulation of interleukin-12 synthesis in human endothelial cells. Eur. J. Immunol. 10:2864-2870.