BCL-2 Family of Proteins and Mammary Cellular Fate

Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia

Volumn 41, Issue 4, 2012, Pages 237-247

  Colitti, M ^a  

^a UNIVERSITY OF UDINE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE; PROTEIN BCL 2;

ANIMAL; APOPTOSIS; CYTOLOGY; FEMALE; LACTATION; METABOLISM; MOUSE; PHYSIOLOGY; PREGNANCY; REVIEW; SIGNAL TRANSDUCTION; UDDER;

ANIMALS; APOPTOSIS; FEMALE; JANUS KINASES; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 84863874277     PISSN: 03402096     EISSN: 14390264     Source Type: Journal    
DOI: 10.1111/j.1439-0264.2012.01134.x     Document Type: Review

References (90)

1. Akers, R. M., W. E. Beal, T. B. Mc Fadden, and A. V. Capuco, 1990: Morphometric analysis of involuting bovine mammary tissue after 21 or 42 days on non-suckling. J. Anim. Sci. 68, 3604-3613.
2. Amstad, P. A., H. Liu, M. Ichimiya, I. K. Berezesky, B. F. Trump, I. A. Buhimschi, and P. L. Gutierrez, 2001: Bcl-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production. Redox Rep. 6, 351-362.
3. Antonsson, B., 2001: Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim, the mitochondrion. Cell Tissue Res. 306, 347-361.
4. Antonsson, B., and J.-C. Martinou, 2000: The bcl-2 protein family. Exp. Cell Res. 256, 50-57.
5. Beckman, K. B., and B. N. Ames, 1998: The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
6. Borner, C., R. Olivier, I. Martinou, C. Mattmann, J. Tschopp, and J.-C. Martinou, 1994: Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis. Biochem. Cell Biol. 72, 463-469.
7. Buttke, T. M., and P. A. Sandstrom, 1994: Oxidative stress a mediator of apoptosis. Immunol. Today, 15, 7-10.
8. Capuco, A. V., and R. M. Akers, 1999: Mammary involution in dairy animals. J. Mammary Gland Biol. Neoplasia 4, 137-144.
9. Capuco, A. V., R. M. Akers, and J. J. Smith, 1997: Mammary growth in Holstein cows during the dry period: quantification of nucleic acids and histology. J. Dairy Sci. 80, 477-487.
10. Capuco, A. V., M. Li, E. Long, S. Ren, K. S. Hruska, K. Schorr, and P. A. Furth, 2002a: Concurrent pregnancy retards mammary involution: effects on apoptosis and proliferation of the mammary epithelium after forced weaning of mice. Biol. Reprod. 66, 1471-1476.
11. Capuco, A. V., S. Ellis, D. L. Wood, R. M. Akers, and W. Garrett, 2002b: Postnatal mammary ductal growth: three-dimensional imaging of cell proliferation, effects of estrogen treatment, and expression of steroid receptors in prepubertal calves. Tissue Cell 34, 143-154.
12. Capuco, A. V., E. Annen, A. C. Fitzgerald, S. E. Ellis, and R. J. Collier, 2006: Mammary cell turnover: relevance to lactation persistency and dry period management. In: Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition of Gene Expression, Immunology and Stress (K. Sejrsen, T. Hvelplund and M. O. Nielsen, eds). Wageningen, The Netherlands: Wageningen Academic Publishers. pp. 363-388.
13. Chen, Z. X., and S. Pervaiz, 2007: Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Differ. 14, 1617-1627.
14. Cheng, E. H., M. C. Wie, S. Weiler, R. A. Flavell, T. W. Mak, T. Lindsten, and S. J. Korsmeyer, 2001: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8, 705-711.
15. Chittenden, T., C. Flemington, A. B. Houghton, R. G. Ebb, G. J. Gallo, B. Elangovan, G. Chinnadurai, and R. J. Lutz, 1995: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 14, 5589-5596.
16. Colitti, M., and M. Farinacci, 2009a: Expression of a putative stem cell marker, Musashi 1, in mammary glands of ewes. J. Mol. Hist. 40, 139-149.
17. Colitti, M., and M. Farinacci, 2009b: Cell turnover and gene activities in sheep mammary glands prior to lambing to involution. Tissue Cell 41, 326-333.
18. Colitti, M., C. J. Wilde, and B. Stefanon, 1999: Functional expression of bcl-2 protein family and AIF in bovine mammary tissue in early lactation. J. Dairy Res. 71, 20-27.
19. Colitti, M., G. Stradaioli, and B. Stefanon, 2000: Effect of α-tocopherol deprivation on the involution of mammary gland in sheep. J. Dairy Sci. 83, 345-350.
20. Colitti, M., R. Musetti, and B. Stefanon, 2004a: Detection of apoptosis-inducing factor in involuting mammary tissue by immunoelectron microscopy. Micron 35, 307-310.
21. Colitti, M., C. J. Wilde, and B. Stefanon, 2004b: Functional expression of bcl-2 protein family and AIF in bovine mammary tissue in early lactation. J. Dairy Res. 71, 20-27.
22. Colitti, M., G. Stradaioli, and B. Stefanon, 2005: Mammary cell turnover in lactating ewes is modulated by changes of energy fuels. Res. Vet. Sci. 78, 53-59.
23. Danial, N. N., and S. J. Korsmeyer, 2004: Cell death: critical control points. Cell 116, 205-219.
24. Daugas, E., D. Nochy, L. Ravagnan, M. Loeffler, S. A. Susin, N. Zamzami, and G. Kroemer, 2000: Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 476, 118-123.
25. Desagher, S., and J.-C. Martinou, 2000: Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10, 369-377.
26. D'Sa-Eipper, C., and G. Chinnadurai, 1998: Functional dissection of Bfl-1, a Bcl-2 homologue: antiapoptosis, oncogene-cooperation and cell proliferation activities. Oncogene, 16, 3105-3114.
27. Edlich, F., S. Banerjee, M. Suzuki, M. M. Cleland, D. Arnoult, C. Wang, A. Neutzer, N. Tjandra, and R. J. Youle, 2011: Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145, 104-116.
28. Ezzoukhry, Z., C. Louandre, C. Francois, Z. Saidak, C. Godin, J.-C. Maziere, and A. Galmiche, 2011: The BH3 mimetic ABT-737 reveals the dynamic regulation of BAD, a pro-apoptotic protein of the BCL2 family, by BCL-XL. Mol. Pharmacol. 79, 997-1004.
29. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson, 1992: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
30. Gilmore, A. P., A. D. Metcalfe, L. H. Romer, and C. H. Streuli, 2000: Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization. J. Cell Biol. 149, 431-446.
31. Gross, A., J. Jockel, M. C. Wei, and S. J. Korsmeyer, 1998: Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17, 3878-3885.
32. Heermeier, K., M. Benedict, M. Li, P. A. Furth, G. Nunez, and L. Hennighausen, 1996: Bax and bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells. Mech. Dev. 56, 197-207.
33. Hirotani, M., Y. Zhang, N. Fujita, M. Naito, and T. Tsuruo, 1999: NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis. J. Biol. Chem. 274, 20415-20420.
34. Hochman, A., H. Sternin, S. Gorodin, S. Korsmayer, I. Ziv, E. Melamed, and D. Offen, 1998: Enhanced oxidative stress and altered antioxidants in brains of bcl-2-deficient mice. J. Neurochem. 71, 741-748.
35. Hockenbery, D. M., 1995: Bcl-2, a novel regulator of cell death. Bioessays 17, 631-638.
36. Hockenbery, D. M., Z. N. Oltvai, X.-M. Yin, C. L. Milliman, and S. J. Korsmeyer, 1993: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
37. Hurley, W. L., 1989: Mammary gland function during involution. J. Dairy Sci. 72, 7-1646.
38. Jang, J. H., and Y. J. Surh, 2003: Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function. Biochem. Pharmacol. 66, 1371-1379.
39. Kannan, K., and S. K. Jain, 2000. Oxidative stress and apoptosis. Pathophysiology 7:153-163.
40. Kim, S. H., Y. S. Moon, W. L. Keller, and C. S. Park, 1998: Compensatory nutrition-directed mammary cell proliferation and lactation in rats. Br. J. Nutr. 79, 177-183.
41. Korsmeyer, S. J., 1999: BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 59(7 Suppl.), 1693s-1700s.
42. Korsmeyer, S. J., J. R. Shutter, D. J Weis, D. E Merry, and Z. N. Oltvai, 1993: Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol. 4, 327-332.
43. Kowaltowski, A. J., R. G. Fenton, and G. Fiskum, 2004: Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic. Biol. Med. 37, 1845-1853.
44. Krishna, S., I. C. Low, and S. Pervaiz, 2011: Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. Biochem. J. 435, 545-551.
45. Lee, Y. J., J. C. Chen, A. A. Amoscato, J. Bennouna, D. R. Spitz, M. Suntharalingam, and J. G. Rhee, 2001: Protective role of bcl-2 in metabolic oxidative stress-induced cell death. J. Cell Sci. 114, 667-684.
46. Letai, A., M. C. Bassik, L. D. Walensky, M. D. Sorcinelli, S. Weiler, and S. J. Korsmeyer, 2002: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2, 183-192.
47. Li, M., X. Liu, G. Robinson, U. Bar-Peled, K.-U. Wagner, W. S. Young, L. Hennighausen, and P. A. Furth, 1997: Mammary-derived signal activate programmed cell death during the first stage of mammary gland involution. Proc. Natl Acad. Sci. USA, 94, 3425-3430.
48. Li, P., P. S. Rudland, D. G. Fernig, L. M. B. Finch, and C. J. Wilde, 1999: Modulation of mammary development and programmed cell death by the frequency of milk removal in lactating goats. J. Physiol. 519, 885-900.
49. Lovell, J. F., L. P. Billen, S. Bindner, A. Shamas-Din, C. Fradin, B. Leber, and D. W. Andrews, 2008: Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135, 1074-1084.
50. Lund, L. R., J. Rømer, N. Thomasset, H. Solberg, C. Pyke, M. J. Bissell, K. Danø, and Z. Werb, 1996: Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122, 181-193.
51. Mailleux, A. A., M. Overholtzer, T. Schmelzle, P. Bouillet, A. Strasser, and J. S Brugge, 2007: BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev. Cell, 12, 221-234.
52. McKenzie, M. D., E. Jamieson, E. S. Jansen, C. L. Scott, D. C. Huang, P. Bouillet, J. Allison, T. W. Kay, A. Strasser, and H. E. Thomas, 2010: Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59, 644-652.
53. Mérino, D., M. Giam, P. D. Hughes, O. M. Siggs, K. Heger, L. A. O'Reilly, J. M. Adams, A. Strasser, E. F. Lee, W. D. Fairlie, and P. Bouillet, 2009: The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J. Cell Biol. 186, 355-362.
54. Metcalfe, A. D., A. Gilmore, T. Klinowska, J. Oliver, A. J. Valentijn, R. Brown, A. Ross, G. MacGregor, J. A. Hickman, and C. H. Streuli, 1999: Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. J. Cell Sci. 112, 1771-1783.
55. Motyl, T., B. Gajkowska, U. Wojewódzka, P. Wareski, A. Rekiel, and T. Płoszaj, 2001: Expression of apoptosis-related proteins in involuting mammary gland of sow. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 128, 635-646.
56. Norberg, E., S. Orrenius, and B. Zhivotovsky, 2010a: Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem. Biophys. Res. Commun. 396, 95-100.
57. Norberg, E., V. Gogvadze, H. Vakifahmetoglu, S. Orrenius, and B. Zhivotovsky, 2010b: Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing. Free Radic. Biol. Med. 48, 791-797.
58. Owens, T. W., A. J. Valentijn, J. P. Upton, J. Keeble, L. Zhang, J. Lindsay, N. K. Zouq, and A. P. Gilmore, 2009: Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK. Cell Death Differ. 16, 1551-1562.
59. Pullan, S., J. Wilson, A. Metcalfe, G. M. Edwards, N. Goberdhan, J. Tilly, J. A. Hickman, C. Dive, and C. H. Streuli, 1996: Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J. Cell Sci. 109, 631-642.
60. Quarrie, L. H., C. V. P. Addey, and C. J. Wilde, 1995: Apoptosis in lactating and involuting mouse mammary tissue. Cell Tissue Res. 281, 413-419.
61. Quarrie, L. H., C. V. Addey, and C. J. Wilde, 1996: Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis. J. Cell. Physiol. 168, 559-569.
62. Rawlings, J. S., K. M. Rosler, and D. A. Harrison, 2004: The JAK/STAT signaling pathway. J. Cell Sci. 117, 1281-1283.
63. Reed, J. C., 1997: Bcl-2 family proteins and hormonal control of cell life and death in normalcy and neoplasia. In: Vitamins and Hormones, Vol. 53 (G. Litwack, ed.). San Diego: Academic Press. pp.99-128.
64. Rucker, E. B. 3rd, A. N. Hale, D. C. Durtschi, K. Sakamoto, and K. U. Wagner, 2011: Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. Genesis 49, 24-35.
65. Sanzari, J. K., C. Wambi, J. S. Lewis-Wambi, and A. R. Kennedy, 2011: Antioxidant dietary supplementation in mice exposed to proton radiation attenuates expression of programmed cell death-associated genes. Radiat. Res. 175, 650-656.
66. Schmelzle, T., A. A. Mailleux, M. Overholtzer, J. S. Carroll, N. L. Solimini, E. S. Lightcap, O. P. Veiby, and J. S. Brugge, 2007: Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc. Natl Acad. Sci. USA 104, 3787-3792.
67. Schorr, K., M. Li, S. Krajewski, J. C. Reed, and P. A. Furth, 1999: Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J. Mammary Gland Biol. Neoplasia 4, 153-164.
68. Shiau, C. W., J. W. Huang, D. S. Wang, C. C. Yang, C. H. Lin, C. Li, and C. S. Chen, 2006: α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. J. Biol. Chem. 281, 11819-11825.
69. Soriano, M. E., and L. Scorrano, 2011: Traveling Bax and forth from mitochondria to control apoptosis. Cell 145, 15-17.
70. Sreekumar, R., J. Unnikrishnan, A. Fu, J. Nygren, K. R. Short, J. Schimke, R. Barazzoni, and K. S. Nair, 2002a: Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 283, E38-E43.
71. Sreekumar, R., J. Unnikrishnan, A. Fu, J. Nygren, K. R. Short, J. Schimke, R. Barazzoni, and K. S. Nair, 2002b: Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 282, E1055-E1061.
72. Stefanon, B., M. Colitti, G. Gabai, C. H. Knight, and C. J. Wilde, 2002: Mammary apoptosis and lactation persistency in dairy animals. J. Dairy Res. 69, 37-52.
73. Tatarczuch, L., C. Philip, and C. S. Lee, 1997: Involution of sheep mammary gland. J. Anat. 190, 405-416.
74. Virgili, F., M. P. Santini, R. Canali, R. R. Polakowska, A. Heads, and G. Perozzi, 1998: Bcl-2 overexpression in the HaCat cell line is associated with a different fatty acid composition and sensitivity to oxidative stress. Free Radic. Biol. Med. 24, 93-101.
75. Voehringer, D. W., and R. E. Meyn, 2000: Redox aspects of bcl-2 function. Antioxid. Redox Signal. 2, 537-550.
76. Wachsman, J. T., 1996: The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. Mutat. Res. 350, 25-34.
77. Walton, K. D., K. U. Wagner, E. B. Rucker, J. M. Shillingford, K. Miyoshi, and L. Hennighausen, 2001: Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Mech. Dev. 109, 281-293.
78. Wei, M. C., W. X. Zong, E. H. Cheng, T. Lindsten, V. Panoutsakopoulou, A. J. Ross, K. A. Roth, G. R. MacGregor, C. B. Thompson, and S. J. Korsmeyer, 2001: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730.
79. Weindruch, R., R. L. Walford, S. Fligiel, and D. Guthrie, 1986: The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 116, 641-654.
80. Weisiger, R. A., and I. Fridovich, 1973: Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 248, 4793-4796.
81. Wilde, C. J., and C. H. Knight, 1989: Metabolic adaptations in mammary gland during the declining phase of lactation. J. Dairy Sci. 72, 1679-1692.
82. Wilde, C. J., C. P. V. Addey, P. Li, and D. G. Fernig, 1997: Programmed cell death in bovine mammary tissue during lactation and involution. Exp. Physiol. 82, 943-953.
83. Wyllie, A. H., J. F. Kerr, and A. R. Currie, 1980: Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306.
84. Yin, X. M., Z. N. Oltvai, and S. J. Korsmeyer, 1994: BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature, 369, 321-333.
85. Youle, R. J., and A. Strasser, 2008: The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9, 47-59.
86. Yu, W., B. G. Sanders, and K. Kline, 1997: RRR-alpha-Tocopheryl succinate inhibits EL4 thymic lymphoma cell growth by inducing apoptosis and DNA synthesis arrest. Nutr. Cancer 27, 92-101.
87. Yuste, V. J., R. S. Moubarak, C. Delettre, M. Bras, P. Sancho, N. Robert, J. d'Alayer, and S. A. Susin, 2005: Cysteine protease inhibition prevents mitochondrial apoptosis inducing factor (AIF) release. Cell Death Differ. 12, 1445-1448.
88. Zha, H., H. A. Fisk, M. P. Yaffe, and J. C. Reed, 1996: Structure-function comparisons of proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol. 16, 6494-6508.
89. Zhao, Y., B. J. Altman, J. L. Coloff, C. E. Herman, S. R. Jacobs, H. L. Wieman, J. A. Wofford, L. N. Dimascio, O. Ilkayeva, A. Kelekar, T. Reya, and J. C. Rathmell, 2007: Glycogen synthase kinase 3α and 3β mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol. Cell. Biol. 27, 4328-4339.
90. Zhao, Y., J. L. Coloff, E. C. Ferguson, S. R. Jacobs, K. Cui, and J. C. Rathmell, 2008: Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. Biol. Chem. 283, 36344-36353.