The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

Journal of Cell Biology

Volumn 186, Issue 3, 2009, Pages 355-362

  Mérino, Delphine ^a   Giam, Maybelline ^a,b   Hughes, Peter D ^b   Siggs, Owen M ^a,c   Heger, Klaus ^a   O'Reilly, Lorraine A ^a   Adams, Jerry M ^a   Strasser, Andreas ^a   Lee, Erinna F ^a   Fairlie, Walter D ^a   Bouillet, Philippe ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN NOXA; PUMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRAIN COS1; CELL SURVIVAL; CONTROLLED STUDY; KIDNEY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

MUS;

EID: 68549089038     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200905153     Document Type: Article

References (26)

1. Adams, J.M., and S. Cory. 2007. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr. Opin. Immunol. 19:488-496.
2. Bouillet, P., D. Metcalf, D.C.S. Huang, D.M. Tarlinton, T.W.H. Kay, F. Köntgen, J.M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 286:1735-1738.
3. Bouillet, P., S. Cory, L.-C. Zhang, A. Strasser, and J.M. Adams. 2001. Degenerative disorders caused by Bcl-2 deficiency are prevented by loss of its BH3-only antagonist Bim. Dev. Cell. 1:645-653.
4. Cartron, P.F., T. Gallenne, G. Bougras, F. Gautier, F. Manero, P. Vusio, K. Meflah, F.M. Vallette, and P. Juin. 2004. The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol. Cell. 16:807-818.
5. Certo, M., G. Moore Vdel, M. Nishino, G. Wei, S. Korsmeyer, S.A. Armstrong, and A. Letai. 2006. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 9:351-365.
6. Chen, L., S.N. Willis, A. Wei, B.J. Smith, J.I. Fletcher, M.G. Hinds, P.M. Colman, C.L. Day, J.M. Adams, and D.C.S. Huang. 2005. Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell. 17:393-403.
7. Chipuk, J.E., and D.R. Green. 2008. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18:157-164.
8. Chipuk, J.E., J.C. Fisher, C.P. Dillon, R.W. Kriwacki, T. Kuwana, and D.R. Green. 2008. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc. Natl. Acad. Sci. USA. 105:20327-20332.
9. Gallenne, T., F. Gautier, L. Oliver, E. Hervouet, B. Noel, J.A. Hickman, O. Geneste, P.F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J. Cell Biol. 185:279-290.
10. Gavathiotis, E., M. Suzuki, M.L. Davis, K. Pitter, G.H. Bird, S.G. Katz, H.C. Tu, H. Kim, E.H. Cheng, N. Tjandra, and L.D. Walensky. 2008. BAX activation is initiated at a novel interaction site. Nature. 455:1076-1081.
11. Hinds, M.G., C. Smits, R. Fredericks-Short, J.M. Risk, M. Bailey, D.C. Huang, and C.L. Day. 2007. Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death Differ. 14:128-136.
12. Jabbour, A.M., J.E. Heraud, C.P. Daunt, T. Kaufmann, J. Sandow, L.A. O'Reilly, B.A. Callus, A. Lopez, A. Strasser, D.L. Vaux, and P.G. Ekert. 2009. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ. 16:555-563.
13. Kim, H., M. Rafiuddin-Shah, H.C. Tu, J.R. Jeffers, G.P. Zambetti, J.J. Hsieh, and E.H. Cheng. 2006. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat. Cell Biol. 8:1348-1358.
14. Kuwana, T., L. Bouchier-Hayes, J.E. Chipuk, C. Bonzon, B.A. Sullivan, D.R. Green, and D.D. Newmeyer. 2005. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol. Cell. 17:525-535.
15. Lee, E.F., L. Chen, H. Yang, P.M. Colman, D.C. Huang, and W.D. Fairlie. 2008. EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency. Cell Death Differ. 15:1609-1618.
16. Lemckert, F.A., J.D. Sedgwick, and H. Korner. 1997. Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro. Nucleic Acids Res. 25:917-918.
17. Letai, A., M. Bassik, L. Walensky, M. Sorcinelli, S. Weiler, and S. Korsmeyer. 2002. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. 2:183-192.
18. Lovell, J.F., L.P. Billen, S. Bindner, A. Shamas-Din, C. Fradin, B. Leber, and D.W. Andrews. 2008. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell. 135:1074-1084.
19. Nakayama, K., K.-I. Nakayama, I. Negishi, K. Kuida, H. Sawa, and D.Y. Loh. 1994. Targeted disruption of bcl-2αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. USA. 91:3700-3704.
20. O'Connor, L., A. Strasser, L.A. O'Reilly, G. Hausmann, J.M. Adams, S. Cory, and D.C.S. Huang. 1998. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 17:384-395.
21. Oltersdorf, T., S.W. Elmore, A.R. Shoemaker, R.C. Armstrong, D.J. Augeri, B.A. Belli, M. Bruncko, T.L. Deckwerth, J. Dinges, P.J. Hajduk, et al. 2005. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 435:677-681.
22. Strasser, A. 2005. The role of BH3-only proteins in the immune system. Nat. Rev. Immunol. 5:189-200.
23. Walensky, L.D., K. Pitter, J. Morash, K.J. Oh, S. Barbuto, J. Fisher, E. Smith, G.L. Verdine, and S.J. Korsmeyer. 2006. A stapled BID BH3 helix directly binds and activates BAX. Mol. Cell. 24:199-210.
24. S-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. J. Cell Biol. 177:625-636.
25. Willis, S.N., L. Chen, G. Dewson, A. Wei, E. Naik, J.I. Fletcher, J.M. Adams, and D.C. Huang. 2005. Pro-apoptotic Bak is sequestered by Mc1-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19:1294-1305.
26. Willis, S.N., J.I. Fletcher, T. Kaufmann, M.F. van Delft, L. Chen, P.E. Czabotar, H. Ierino, E.F. Lee, W.D. Fairlie, P. Bouillet, et al. 2007. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 315:856-859.