Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

Journal of Cell Science

Volumn 112, Issue 11, 1999, Pages 1771-1783

  Metcalfe, Anthony D ^a   Gilmore, Andrew ^a   Klinowska, Teresa ^a   Oliver, Janine ^a   Valentijn, Anthony J ^a   Brown, Robin ^b   Ross, Andrea ^c   MacGregor, Grant ^c   Hickman, John A ^a   Streuli, Charles H ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bak; Bcl w; Breast; Mammary gland

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DIMERIZATION; DNA TRANSFECTION; FEMALE; GENE EXPRESSION; INVOLUTION; LACTATION; MAMMARY GLAND; MOUSE; MULTIGENE FAMILY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; DOWN-REGULATION; EPITHELIAL CELLS; ESTRUS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LACTATION; MAMMARY GLANDS, ANIMAL; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; PREGNANCY; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; EUKARYOTA;

EID: 0032980834     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Adams, J. M. and Cory, S. (1998). The Bcl-2 protein family: Arbiters of cell survival. Science 281, 1322-1326.
2. Aggeler, J., Ward, J., Blackie, L. M., Barcelios-Hoff, M. H., Streuli, C. H. and Bissell, M. J. (1991). Cytodifferentiation of mouse mammary epithelial-cells cultured on a reconstituted basement-membrane reveals striking similarities to development in vivo. J. Cell Sci. 99, 407-417.
3. Anderson, E., Clarke, R. B. and Howell, A. (1997). Changes in the normal human breast throughout the menstrual cycle: Relevance to breast carcinogenesis. Endocrine-Related Cancer 4, 23-33.
4. Andres, A. C., Zuercher, G., Djonov, V., Flueck, M. and Ziemiecki, A. (1995). Protein-tyrosine kinase expression during the estrous-cycle and carcinogenesis of the mammary-gland. Int. J. Cancer. 63, 288-296.
5. Bargou, R. C., Daniel, P. T., Mapara, M. Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H. D. and Dorken, B. (1995). Expression of the Bcl-2 gene family in normal and malignant breast-tissue - low Bax-alpha expression in tumor-cells correlates with resistance towards apoptosis. Int. J. Cancer 60, 854-859.
6. Cheng, E. H. Y., Levine, B., Boise, L. H., Thompson, C. B. and Hardwick, J. M. (1996). Bax-independent inhibition of apoptosis by Bcl-X(L). Nature 379, 554-556.
7. Conradt, B. and Horvitz, H. R. (1998). The C-elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529.
8. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Goto, Y. and Greenberg, M. E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
9. Farrow, S. N. and Brown, R. (1996). New members of the Bcl-2 family and their protein partners. Curr. Opin. Genet. Oev. 6, 45-49.
10. Farrow, S. N., White, J. H. M., Martinou, I., Raven, T., Pun, K. T., Grinham, C. J., Martinou, J. C. and Brown, R. (1995). Cloning of a Bcl-2 homolog by interaction with adenovirus E1b 19k. Nature 374, 731-733.
11. Feng, Z. W., Marti, A., Jehn, B., Altermatt, H. J., Chicaiza, G. and Jaggi, R. (1995). Glucocorticoid and progesterone inhibit invólution and programmed cell-death in the mouse mammary-gland. J. Cell Biol. 131, 1095-1103.
12. Gibson, L., Holmgreen, S. P., Huang, D. C. S., Bernand, O., Copeland, N. G., Jenkins, N. A., Sutherland, G. R., Baker, E., Adams, J. M. and Cory, S. (1996). Bcl-W, a novel member of the Bcl-2 family, promotes cell-survival. Oncogene 13, 665-675.
13. Green, D. and Kroemer, G. (1998). The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 8, 267-271.
14. Gross, A., Jockel, J., Wei, M. C. and Korsmeyer, S. J. (1998). Enforced dimerization of Bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17, 3878-3885.
15. Heermeier, K., Benedict, M., Li, M. L., Furth, P., Nunez, G. and Henninghausen, L. (1996). Bax and Bcl-X(S) are induced at the onset of apoptosis in involuting mammary epithelial-cells. Mech. Dev. 56, 197-207.
16. Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. and Korsmeyer, S. J. (1991). Bcl2 protein is topographically restricted in tissues characterized by apoptotic cell-death. Proc. Natl Acad. Sci. USA 88, 6961-6965.
17. Ito, T., Deng, X., Carr, B. and May, W. S. (1997). Bcl-2 phosphorylation required for anti-apoptosis function. J. Biol. Chem. 272, 11671-11673.
18. Jacobson, M. D. (1997). Apoptosis: Bcl-2-related proteins get connected. Curr. Biol. 7, R277-R281.
19. Jager, R., Herzer, U., Schenkel, J. and Weiher, H. (1997). Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene 15, 1787-1795.
20. Kittrell, F. S., Oborn, C. J. and Medina, D. (1992). Development of Mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro. Cancer Res. 52, 1924-1932.
21. Kluck, R. M., Bossy Wetzel, E., Green, D. R. and Newmeyer, D. D. (1997). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132-1136.
22. Knudson, C. M. and Korsmeyer, S. J. (1997). Bcl-2 and Bax function independently to regulate cell death. Nat. Genet. 16, 358-363.
23. Knudson, C. M., Tung, K. S. K., Tourtellotte, W. G., Brown, G. A. J. and Korsmeyer, S. J. (1995). Bax-deficient mice with lymphoid hyperplasia and male germ-cell death. Science 270, 96-99.
24. Krajewski, S., Blomqvist, C., Franssila, K., Krajewska, M., Wasenius, V. M., Niskanen, E., Nordling, S. and Reed, J. C. (1995). Reduced expression of proapoptotic gene Bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res. 55, 4471-4478.
25. Krajewski, S., Krajewska, M., Shabaik, A., Miyashita, T., Wang, H. G. and Reed, J. C. (1994). Immunohistochemical determination of in-vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Path. 145, 1323-1336.
26. Leung, L. K., Do, L. and Wang, T. T. (1998). Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells. Cancer Lett. 124, 47-52.
27. Ling, Y.-H., Tornos, C. and Perez-Soler, R. (1998). Phosphorylation of Bcl-2 is a marker for M phase events and not a determinant of apoptosis. J. Biol. Chem. 273, 18984-18991.
28. Lund, L. R., Romer, J., Thomasset, N., Solberg, H., Pyke, C., Bissell, M. J., Dano, K. and Werb, Z. (1996). 2 distinct phases of apoptosis in mammary-gland involution - proteinase-independent and proteinase-dependent pathways. Development 122, 181-193.
29. Metcalfe, A. and Streuli, C. (1997). Epithelial apoptosis. BioEssays 19, 711-720.
30. Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S. and Loh, D. Y. (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-1510.
31. Oltvai, Z. N., Milliman, C. L. and Korsmeyer, S. J. (1993). Bcl-2 heterodimerizes in-vivo with a conserved homolog, Bax, that accelerates programmed cell-death. Cell 74, 609-619.
32. Print, C. G., Loveland, K. L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N., de Kretser, D., Metcalfe, D., Köntgen, F., Adams, J. M. and Cory, S. (1998). Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc. Natl. Acad. Sci. USA 95, 12424-12431.
33. Pullan, S. and Streuli, C. H. (1996). The mammary gland epithelial cell. Epithelial Cell Culture (ed. A. Harris), pp. 97-121. Cambridge: Cambridge University Press.
34. Pullan, S., Wilson, J., Metcalfe, A., Edwards, G. M., Goberdhan, N., Tilly, J., Hickman, J. A., Dive, C. and Streuli, C. H. (1996). Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J. Cell Sci. 109, 631-642.
35. Ross, A. J., Waymire, K. G., Moss, J. E., Parlow, A. F., Skinner, M. K., Russell, L. D. and MacGregor, G. R. (1998). Testicular degeneration in Bclw-deficient mice. Nat. Genet. 18, 251-256.
36. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, MA: Cold Spring Harbor Laboratory Press.
37. Simonian, P. L., Grillot, D. A. and Nunez, G. (1997). Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2. Oncogene 15, 1871-1875.
38. St Clair, E. G., Anderson, S. J. and Oltvai, Z. N. (1997). Bcl-2 counters apoptosis by Bax heterodimerization-dependent and -independent mechanisms in the T-cell lineage. J. Biol. Chem. 272, 29347-29355.
39. Strange, R., Li, F., Saurer, S., Burkhardt, A. and Friis, R. R. (1992). Apoptotic cell-death and tissue remodeling during mouse mammary-gland involution. Development 115, 49-58.
40. Streuli, C. H. and Bissell, M. J. (1990). Expression of extracellular matrix components is regulated by substratum. J. Cell Biol. 110, 1405-1415.
41. Streuli, C. H., Dive, C., Hickman, J. A., Farrelly, N. and Metcalfe, A. (1997). Control of apoptosis in breast epithelium. Endocrine-Related Cancer 4, 45-53.
42. Teixeira, C., Reed, J. C. and Pratt, M. A. (1995). Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res. 55, 3902-3907.
43. Tonner, E., Barber, M. C., Travers, M. T., Logan, A. and Flint, D. J. (1997). Hormonal control of insulin-like growth factor binding protein-5 production in the involuting mammary gland of the rat. Endocrinology 138, 5101-5107.
44. Vander Heiden, M. G., Chandel, N. S., Williamson, E. K., Schumacker, P. T. and Thompson, C. B. (1997). Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627-637.
45. Veis, D. J., Sorenson, C. M., Shutter, J. R. and Korsmeyer, S. J. (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75, 229-240.
46. Wang, T. T. and Phang, J. M. (1995). Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res. 55, 2487-2489.
47. Wolter, K. G., Hsu, Y. T., Smith, C. L., Nechushtan, A., Xi, X. G. and Youle, R. J. (1997). Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139, 1281-1292.
48. Yin, X. M., Oltvai, Z. N. and Korsmeyer, S. J. (1994). BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369, 321-323.
49. Zapata, J. M., Krajewska, M., Krajewski, S., Huang, R. P., Takayama, S., Wang, H. G., Adamson, E. and Reed, J. C. (1998). Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors. Breast Cancer Res. Treat 47, 129-140.
50. Zou, H., Henzel, W. J., Liu, X., Lutschg, A. and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.