Antioxidant dietary supplementation in mice exposed to proton radiation attenuates expression of programmed cell death-associated genes

Radiation Research

Volumn 175, Issue 5, 2011, Pages 650-656

  Sanzari, J K ^a   Wambi, C ^a   Lewis Wambi, J S ^b   Kennedy, A R ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c 95 John Morgan Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CASPASE 3; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW; DIET SUPPLEMENTATION; GENE EXPRESSION; HEMATOPOIETIC CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON RADIATION; RADIATION DOSE; UPREGULATION; WHOLE BODY RADIATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-X PROTEIN; BONE MARROW CELLS; CELL COUNT; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; MALE; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTONS; RNA, MESSENGER; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; WHOLE-BODY IRRADIATION;

ANIMALIA; MUS;

EID: 79955387273     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2330.1     Document Type: Article

References (34)

1. J. L. Parsons and L. W. Townsend, Interplanetary crew dose rates for the August 1972 solar particle event. Radiat. Res. 153, 729-733 (2000). (Pubitemid 30349547)
2. C. Wambi, J. Sanzari, X. S. Wan, M. Nuth, J. Davis, Y. H. Ko, C. M. Sayers, M. Baran, J. H. Ware and A. R. Kennedy, Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat. Res. 169, 384-396 (2008). (Pubitemid 351620037)
3. A. R. Kennedy, J. G. Davis, W. Carlton and J. H. Ware, Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation. Radiat. Res. 169, 615-625 (2008). (Pubitemid 351793451)
4. C. O. Wambi, J. K. Sanzari, C. M. Sayers, M. Nuth, Z. Zhou, J. Davis, N. Finnberg, J. S. Lewis-Wambi, J. H. Ware and A. R. Kennedy, Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival. Radiat. Res. 172, 175-186 (2009).
5. A. Ristic-Fira, D. Nikolic, I. Petrovic, S. Ruzdijic, L. Raffaele, M. G. Sabini, G. A. Cirrone, G. Cuttone, G. Farruggia and D. T. Kanazir, The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line. J. Exp. Clin. Cancer Res. 20, 135-143 (2001). (Pubitemid 32423984)
6. K. B. Lee, J. S. Lee, J. W. Park, T. L. Huh and Y. M. Lee, Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. Exp. Mol. Med. 40, 118-129 (2008).
7. C. Di Pietro, S. Piro, G. Tabbi, M. Ragusa, V. Di Pietro, V. Zimmitti, F. Cuda, M. Anello, U. Consoli and M. Purrello, Cellular and molecular effects of protons: apoptosis induction and potential implications for cancer therapy. Apoptosis 11, 57-66 (2006). (Pubitemid 43151644)
8. N. A. Thornberry and Y. Lazebnik, Caspases: enemies within. Science 281, 1312-1316 (1998). (Pubitemid 28406817)
9. A. Prentice, F. Branca, T. Decsi, K. F. Michaelsen, R. J. Fletcher, P. Guesry, F. Manz, M. Vidailhet, D. Pannemans and S. Samartin, Energy and nutrient dietary reference values for children in Europe: methodological approaches and current nutritional recommendations. Br. J. Nutr. 92 (Suppl. 2), S82-S146 (2004).
10. M. L. Aitio, Nacetylcysteine - passe-partout or much ado about nothing? Br. J. Clin. Pharmacol. 61, 5-15 (2006).
11. S. D. Wollin and P. J. Jones, Alpha-lipoic acid and cardiovascular disease. J. Nutr. 133, 3327-3330 (2003).
12. P. M. De Angelis, T. Stokke, L. Thorstensen, R. A. Lothe and O. P. Clausen, Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype. Mol. Pathol. 51, 254-261 (1998). (Pubitemid 28480342)
13. Y. A. Lazebnik, S. H. Kaufmann, S. Desnoyers, G. G. Poirier and W. C. Earnshaw, Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347 (1994). (Pubitemid 24300618)
14. D. Brenner and T. W. Mak, Mitochondrial cell death effectors. Curr. Opin. Cell Biol. 21, 871-877 (2009).
15. J. M. Dai, D. C. Sun, R. X. Lin, J. Yang, S. Lou and S. Q. Wang, Microarray analysis of differentially expressed genes in mouse bone marrow tissues after ionizing radiation. Int. J. Radiat. Biol. 82, 511-521 (2006). (Pubitemid 44174869)
16. T. F. Burns and W. S. El-Deiry, Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation. Cancer Biol. Ther. 2, 431-443 (2003).
17. J. Yang, X. Liu, K. Bhalla, C. N. Kim, A. M. Ibrado, J. Cai, T. I. Peng, D. P. Jones and X. Wang, Prevention of apoptosis by Bcl- 2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132 (1997). (Pubitemid 27097312)
18. D. R. Green and J. C. Reed, Mitochondria and apoptosis. Science 281, 1309-1312 (1998). (Pubitemid 28406816)
19. P. Juin and G. Evan, Caspase 8: the killer you can't live without. Nat. Med. 6, 498-500 (2000).
20. T. Ushakova, H. Melkonyan, L. Nikonova, V. Afanasyev, A. I. Gaziev, N. Mudrik, R. Bradbury and V. Gogvadze, Modification of gene expression by dietary antioxidants in radiation-induced apoptosis of mice splenocytes. Free Radic. Biol. Med. 26, 887-891 (1999). (Pubitemid 29198361)
21. M. Kernt, C. Hirneiss, A. S. Neubauer, M. W. Ulbig and A. Kampik, Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX/Bcl-2 ratio. Acta Ophthalmol. 88, e78- e86 (2010).
22. X. S. Wan, P. Bloch, J. H. Ware, Z. Zhou, J. J. Donahue, J. Guan, J. Stewart and A. R. Kennedy, Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cells. Radiat. Res. 163, 364-368 (2005). (Pubitemid 40404643)
23. J. K. Leach, G. Van Tuyle, P. S. Lin, R. Schmidt-Ullrich and R. B. Mikkelsen, Ionizing radiation-induced, mitochondriadependent generation of reactive oxygen/nitrogen. Cancer Res. 61, 3894-3901 (2001). (Pubitemid 32720947)
24. X. S. Wan, J. H. Ware, Z. Zhou, J. J. Donahue, J. Guan and A. R. Kennedy, Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents. Int. J. Radiat. Oncol. Biol. Phys. 64, 1475-1481 (2006).
25. J. Bai and A. I. Cederbaum, Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-alpha-induced apoptosis. J. Biol. Chem. 275, 19241-19249 (2000). (Pubitemid 30422896)
26. J. Bai, A. M. Rodriguez, J. A. Melendez and A. I. Cederbaum, Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury. J. Biol. Chem. 274, 26217-26224 (1999).
27. M. Durante and F. A. Cucinotta, Heavy ion carcinogenesis and human space exploration. Nat. Rev. Cancer 8, 465-472 (2008). (Pubitemid 351744960)
28. C. K. Hill, B. Nagy, C. Peraino and D. J. Grdina, 2- [(Aminopropyl)amino] ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation. Carcinogenesis 7, 665-668 (1986). (Pubitemid 17135431)
29. B. A. Carnes and D. J. Grdina, In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis. Int. J. Radiat. Biol. 61, 567-576 (1992).
30. D. J. Grdina, Y. Kataoka and J. S. Murley, Amifostine: mechanisms of action underlying cytoprotection and chemoprevention. Drug Metabol. Drug Interact. 16, 237-279 (2000). (Pubitemid 32048250)
31. A. R. Kennedy, Z. Zhou, J. J. Donahue and J. H. Ware, Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants. Radiat. Res. 166, 327-332 (2006). (Pubitemid 44157369)
32. X. S. Wan, T. C. Hamilton, J. H. Ware, J. J. Donahue and A. R. Kennedy, Growth inhibition and cytotoxicity induced by Bowman-Birk inhibitor concentrate in cisplatin-resistant human ovarian cancer cells. Nutr. Cancer 31, 8-17 (1998). (Pubitemid 28345971)
33. L. Zhang, X. S. Wan, J. J. Donahue, J. H. Ware and A. R. Kennedy, Effects of the Bowman-Birk inhibitor on clonogenic survival and cisplatin- or radiation-induced cytotoxicity in human breast, cervical, and head and neck cancer cells. Nutr. Cancer 33, 165-173 (1999). (Pubitemid 29270004)
34. K. Dittmann, H. Loffler, M. Bamberg and H. P. Rodemann, Bowman-Birk proteinase inhibitor (BBI) modulates radiosensitivity and radiation-induced differentiation of human fibroblasts in culture. Radiother. Oncol. 34, 137-143 (1995).