Distribution and functions of sterols and sphingolipids

Cold Spring Harbor Perspectives in Biology

Volumn 3, Issue 5, 2011, Pages 1-14

  Hannich, J Thomas ^a   Umebayashi, Kyohei ^a   Riezman, Howard ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA; FUNGI; INVERTEBRATA; PROKARYOTA; VERTEBRATA;

SPHINGOLIPID; STEROL;

ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL FRACTIONATION; CELL MEMBRANE; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL FRACTIONATION; CELL MEMBRANE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; STEROLS;

EID: 84863858787     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a004762     Document Type: Article

References (111)

1. Acharya U, Acharya JK. 2005. Enzymes of sphingolipid metabolism in Drosophila melanogaster. Cell Mol Life Sci 62: 128-142.
2. Aguilar PS, Heiman MG, Walther TC, Engel A, SchwudkeD, Gushwa N, Kurzchalia T, Walter P. 2010. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proc Natl Acad Sci 107: 4170-4175.
3. Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, et al. 2010. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465: 1084-1088.
4. Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, Powers T. 2008. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 7: 148-158.
5. Bagnat M, Simons K. 2002. Cell surface polarization during yeast mating. Proc Natl Acad Sci 99: 14183-14188.
6. Bagnat M, Keranen S, Shevchenko A, Simons K. 2000. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci 97: 3254-3259.
7. Bartz F, Kern L, Erz D, Zhu M, Gilbert D, Meinhof T, WirknerU, Erfle H, Muckenthaler M, Pepperkok R, et al. 2009. Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab 10: 63-75.
8. Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch M. 2009. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J 28: 3706-3716.
9. Beck T, Schmidt A, Hall MN. 1999. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J Cell Biol 146: 1227-1238.
10. 2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide. Mol Gen Genet 255: 570-579.
11. Benveniste P. 1986. Sterol Biosynthesis. Ann Rev Plant Physiol Plant Mol Biol 37: 275-308.
12. Bird CW, Lynch JM, Pirt FJ, Reid WW. 1971. Steroids and squalene inMethylococcus capsulatus grown on methane. Nature 230: 473-474.
13. Bourquin F, Riezman H, Capitani G, Grutter MG. 2010. Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 18: 1054-1065.
14. Carvalho M, Schwudke D, Sampaio JL, PalmW, Riezman I, Dey G, Gupta GD, Mayor S, Riezman H, Shevchenko A, et al. 2010. Survival strategies of a sterol auxotroph. Development 137: 3675-3685.
15. Castillon GA, Watanabe R, Taylor M, Schwabe TM, Riezman H. 2009. Concentration of GPI-anchored proteins upon ER exit in yeast. Traffic 10: 186-200.
16. Chitwood DJ, Lusby WR, Thompson MJ, Kochansky JP, Howarth OW. 1995. The glycosylceramides of the nematode Caenorhabditis elegans contain an unusual, branched-chain sphingoid base. Lipids 30: 567-573.
17. Clayton RB. 1964. The utilization of sterols by insects. J Lipid Res 15: 3-19.
18. Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X. 2010. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol 6: 349.
19. Daicho K, Makino N, Hiraki T, Ueno M, Uritani M, Abe F, Ushimaru T. 2009. Sorting defects of the tryptophan permease Tat2 an erg2 yeast mutant. FEMS Microbiol Lett 298: 218-227.
20. Deng X, Yin X, Allan R, Lu DD, Maurer CW, Haimovitz-Friedman A, Fuks Z, Shaham S, Kolesnick R. 2008. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science 322: 110-115.
21. Derry JM, Gormally E, MeansGD, ZhaoW, Meindl A, Kelley RI, Boyd Y, Herman GE. 1999. Mutations in a D8-D7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. Nat Genet 22: 286-290.
22. Desmond E, Gribaldo S. 2009. Phylogenomics of sterol synthesis: Insights into the origin, evolution, and diversity of a key eukaryotic feature. Genome Biol Evol 1: 364-381.
23. Dickson RC. 2008. Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast. J Lipid Res 49: 909-921.
24. Dickson RC, Lester RL. 1999. Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1438: 305-321.
25. Dickson RC, Sumanasekera C, Lester RL. 2006. Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog Lipid Res 45: 447-465.
26. Dunn TM, Gable K, Monaghan E, Bacikova D. 2000. Selection of yeast mutants in sphingolipid metabolism. Methods Enzymol 312: 317-330.
27. Ejsing CS, Sampaio JL, Surendranath V, Duchoslav E, Ekroos K, Klemm RW, Simons K, Shevchenko A. 2009. Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci 106: 2136-2141.
28. Emter R, Heese-Peck A, Kralli A. 2002. ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521: 57-61.
29. Fei W, Alfaro G, Muthusamy BP, Klaassen Z, Graham TR, Yang H, Beh CT. 2008. Genome-wide analysis of sterollipid storage and trafficking in Saccharomyces cerevisiae. Eukaryot Cell 7: 401-414.
30. Fitzky BU, Glossmann H, Utermann G, Moebius FF. 1999. Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism. Curr Opin Lipidol 10: 123-131.
31. Friant S, Zanolari B, Riezman H. 2000. Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. EMBO J 19: 2834-2844.
32. Friant S, Lombardi R, Schmelzle T, Hall MN, Riezman H. 2001. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20: 6783-6792.
33. Funato K, Riezman H. 2001. Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. J Cell Biol 155: 949-959.
34. Futerman AH, Riezman H. 2005. The ins and outs of sphingolipid synthesis. Trends Cell Biol 15: 312-318.
35. Fyrst H, Saba JD. 2010. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 6: 489-497.
36. Gaber RF, Copple DM, Kennedy BK, Vidal M, Bard M. 1989. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol Cell Biol 9: 3447-3456.
37. Gaigg B, Toulmay A, Schneiter R. 2006. Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast. J Biol Chem 281: 34135-34145.
38. Gaigg B, Timischl B, Corbino L, Schneiter R. 2005. Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast. J Biol Chem 280: 22515-22522.
39. Galea AM, Brown AJ. 2009. Special relationship between sterols and oxygen:Were sterols an adaptation to aerobic life? Free Radic Biol Med 47: 880-889.
40. Garrenton LS, Young SL, Thorner J. 2006. Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20: 1946-1958.
41. Gaylor JL. 2002. Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Comm 292: 1139-1146.
42. Geiger O, Gonzalez-Silva N, Lopez-Lara IM, Sohlenkamp C. 2010. Amino acid-containing membrane lipids in bacteria. Prog Lipid Res 49: 46-60.
43. Guan XL, Souza CM, Pichler H, Dewhurst G, Schaad O, Kajiwara K, Wakabayashi H, Ivanova T, Castillon GA, Piccolis M, et al. 2009. Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell 20: 2083-2095.
44. Haines TH. 2001. Do sterols reduce proton and sodium leaks through lipid bilayers?. Prog Lipid Res 40: 299-324.
45. Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, et al. 2009. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325: 1254-1257.
46. Han X, Jiang X. 2009. A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications. Eur J Lipid Sci Technol 111: 39-52.
47. Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. 2003. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426: 803-809.
48. Hannun YA, Obeid LM. 2009. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 9: 139-150.
49. Hannich JT, Entchev EV, Mende F, Boytchev H, Martin R, Zagoriy V, Theumer G, Riezman I, Riezman H, Knolker HJ, et al. 2009. Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans. Dev Cell 16: 833-843.
50. Heese-Peck A, Pichler H, Zanolari B, Watanabe R, Daum G, Riezman H. 2002. Multiple functions of sterols in yeast endocytosis. Mol Biol Cell 13: 2664-2680.
51. Ho CH, Magtanong L, Barker SL, Gresham D, Nishimura S, Natarajan P, Koh JL, Porter J, Gray CA, Andersen RJ, et al. 2009. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nat Biotechnol 27: 369-377.
52. Horvath A, Sutterlin C, Manning-KriegU, Movva NR, Riezman H. 1994. Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J 13: 3687-3695.
53. Imgrund S, Hartmann D, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Gieselmann V, Sandhoff K, Willecke K. 2009. Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem 284: 33549-33560.
54. Jiang X, Cheng H, Yang K, Gross RW, Han X. 2007. Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids. Anal Biochem 371: 135-145.
55. Jin H, McCaffery JM, Grote E. 2008. Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast. J Cell Biol 180: 813-826.
56. Kajiwara K, Watanabe R, Pichler H, Ihara K, Murakami S, Riezman H, Funato K. 2008. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol Biol Cell 19: 2069-2082.
57. Klemm RW, Ejsing CS, Surma MA, Kaiser HJ, Gerl MJ, Sampaio JL, de Robillard Q, Ferguson C, Proszynski TJ, Shevchenko A, et al. 2009. Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network. J Cell Biol 185: 601-612.
58. Kurzchalia TV, Ward S. 2003. Why do worms need cholesterol?. Nat Cell Biol 5: 684-688.
59. Lamb DC, Jackson CJ, Warrilow AG, Manning NJ, Kelly DE, Kelly SL. 2007. Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: Insight into the evolution of sterol biosynthesis. Mol Biol Evol 24: 1714-1721.
60. Lee MCS, Hamamoto S, Schekman R. 2002. Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum. J Biol Chem 277: 22395-22401.
61. Lingwood D, Simons K. 2010. Lipid rafts as a membraneorganizing principle. Science 327: 46-50.
62. Lisman Q, Pomorski T, Vogelzangs C, Urli-Stam D, de Cocq van Delwijnen W, Holthuis JC. 2004. Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids. J Biol Chem 279: 1020-1029.
63. Liu K, Zhang X, Lester RL, Dickson RC. 2005. The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. J Biol Chem 280: 22679-22687.
64. Marza E, Simonsen KT, Faergeman NJ, Lesa GM. 2009. Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. J Cell Sci 122: 822-833.
65. Meier KD, Deloche O, Kajiwara K, Funato K, Riezman H. 2006. Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell 17: 1164-1175.
66. Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. 2009. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 324: 381-384.
67. Merrill AH Jr, Stokes TH, Momin A, Park H, Portz BJ, Kelly S, Wang E, Sullards MC, Wang MD. 2009. Sphingolipidomics: A valuable tool for understanding the roles of sphingolipids in biology and disease. J Lipid Res 50 Suppl: S97-102.
68. Mesmin B, Maxfield FR. 2009. Intracellular sterol dynamics. Biochim Biophys Acta 1791: 636-645.
69. Munn AL, Riezman H. 1994. Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes. J Cell Biol 127: 373-386.
70. Munn AL, Heese-Peck A, Stevenson BJ, Pichler H, Riezman H. 1999. Specific sterols required for the internalization step of endocytosis in yeast. Mol Biol Cell 10: 3943-3957.
71. Nakase M, Tani M, Morita T, Kitamoto HK, Kashiwazaki J, Nakamura T, Hosomi A, Tanaka N, Takegawa K. 2010. Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe. J Cell Sci 123: 1578-1587.
72. Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A, Kawasaki H, Kakeya H, Kobayashi T, Matsunaga S, et al. 2010. Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling. Nat Chem Biol 6: 519-526.
73. Ohyama K, Suzuki M, Kikuchi J, Saito K, Muranaka T. 2009. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. Proc Natl Acad Sci 106: 725-730.
74. Osborne TF, Espenshade PJ. 2009. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action:What a long, strange tRIP it's been. Genes Dev 23: 2578-2591.
75. Pata MO, Hannun YA, Ng CK. 2010. Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol 185: 611-630.
76. Pearson A, Budin M, Brocks JJ. 2003. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proc Natl Acad Sci 100: 15352-15357.
77. Penno A, Reilly MM, Houlden H, Laura M, Rentsch K, Niederkofler V, Stoeckli ET, Nicholson G, Eichler F, Brown RH Jr, et al. 2010. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. J Biol Chem 285: 11178-11187.
78. Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, et al. 2010a. A critical role for ceramide synthase 2 in liver homeostasis: II. Insights into molecular changes leading to hepatopathy. J Biol Chem 285: 10911-10923.
79. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brugger B, Sachsenheimer T, Wieland F, et al. 2010b. A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways. J Biol Chem 285: 10902-10910.
80. Pryciak PM, Huntress FA. 1998. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβg complex underlies activation of the yeast pheromone response pathway. Genes Dev 12: 2684-2697.
81. Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS. 2008. Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: A delicate balance. Cell Metab 8: 512-521.
82. Rao RP, Acharya JK. 2008. Sphingolipids and membrane biology as determined from genetic models. Prostaglandins Other Lipid Mediat 85: 1-16.
83. Reggiori F, Canivenc-Gansel E, Conzelmann A. 1997. Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. EMBO J 16: 3506-3518.
84. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290-303.
85. Santarella-Mellwig R, Franke J, Jaedicke A, Gorjanacz M, Bauer U, Budd A, Mattaj IW, Devos DP. 2010. The compartmentalized bacteria of the planctomycetesverrucomicrobia-chlamydiae superphylum have membrane coat-like proteins. PLoS Biol 8: e1000281.
86. Schmidt A, Beck T, Koller A, Kunz J, Hall MN. 1998. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J 17: 6924-6931.
87. Schonbachler M, Horvath A, Fassler J, Riezman H. 1995. The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis. EMBO J 14: 1637-1645.
88. Schwudke D, Schuhmann K, Herzog R, Bornstein SR, Shevchenko A. 2011. Shotgun lipidomics on high resolution mass spectrometers. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a004614.
89. Silberkang M, Havel CM, Friend DS, McCarthy BJ, Watson JA. 1983. Isoprene synthesis in isolated embryonic Drosophila cells. I. Sterol-deficient eukaryotic cells. J Biol Chem 258: 8503-8511.
90. Silve S, Dupuy PH, Labit-Lebouteiller C, Kaghad M, Chalon P, Rahier A, Taton M, Lupker J, Shire D, Loison G. 1996. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits D8-D7 sterol isomerase activity in yeast. J Biol Chem 271: 22434-22440.
91. Skrzypek MS, Nagiec MM, Lester RL, Dickson RC. 1998. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J Biol Chem 273: 2829-2834.
92. Sperling P, Heinz E. 2003. Plant sphingolipids: Structural diversity, biosynthesis, first genes and functions. Biochim Biophys Acta 1632: 1-15.
93. Sprong H, Degroote S, Claessens T, van Drunen J, Oorschot V, Westerink BH, Hirabayashi Y, Klumperman J, van der Sluijs P, van Meer G. 2001. Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. J Cell Biol 155: 369-380.
94. Sturgill TW, Cohen A, Diefenbacher M, Trautwein M, Martin DE, Hall MN. 2008. TOR1 and TOR2 have distinct locations in live cells. Eukaryot Cell 7: 1819-1830.
95. Sullards MC, Allegood JC, Kelly S, Wang E, Haynes CA, Park H, Chen Y, Merrill AH Jr. 2007. Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "Inside-out" sphingolipidomics. Methods Enzymol 432: 83-115.
96. Summons RE, Powell TG, Boreham CJ. 1988. Petroleum geology and geochemistry of the Middle Proterozoic McArthur Basin, Northern Australia: III. Composition of extractable hydrocarbons. Geochimica et Cosmochimica Acta 52: 1747-1763.
97. Sun Y, Taniguchi R, Tanoue D, Yamaji T, Takematsu H, Mori K, Fujita T, Kawasaki T, Kozutsumi Y. 2000. Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipidmediated signaling pathway of yeast. Mol Cell Biol 20: 4411-4419.
98. Ternes P, Sperling P, Albrecht S, Franke S, Cregg JM, Warnecke D, Heinz E. 2006. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem 281: 5582-5592.
99. Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. 2006. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol 26: 2817-2831.
100. Umebayashi K, Nakano A. 2003. Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. J Cell Biol 161: 1117-1131.
101. Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC. 2009. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol 185: 1013-1027.
102. Vaena de Avalos S, Okamoto Y, Hannun YA. 2004. Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem 279: 11537-11545.
103. Vinci G, Xia X, Veitia RA. 2008. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: Facts and hypotheses. PLoS One 3: e2883.
104. Volkman JK. 2003. Sterols in microorganisms. Appl Microbiol Biotechnol 60: 495-506.
105. Watanabe R, Funato K, Venkataraman K, Futerman AH, Riezman H. 2002. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J Biol Chem 277: 49538-49544.
106. Weete JD, Abril M, Blackwell M. 2010. Phylogenetic distribution of fungal sterols. PLoS One 5: e10899.
107. Xu J, Dang Y, Ren YR, Liu JO. 2010. Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci 107: 4764-4769.
108. Yamashita M, Matsuda M, Mori T. 1999. In situ detection of prolactin receptor mRNA and apoptotic cell death in mouseuterine tissueswith adenomyosis. InVivo 13: 57-60.
109. Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, et al. 2007. The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol 370: 870-886.
110. Ye J, DeBose-Boyd RA. 2011. Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb Perspect Biol doi:10.1101/cshperspect.a004754.
111. Zanolari B, Friant S, Funato K, Sutterlin C, Stevenson BJ, Riezman H. 2000. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J 19: 2824-2833.