Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33549-33560

  Imgrund, Silke ^a   Hartmann, Dieter ^a   Farwanah, Hany ^a   Eckhardt, Matthias ^a   Sandhoff, Roger ^b   Degen, Joachim ^a   Gieselmann, Volkmar ^a   Sandhoff, Konrad ^a   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CERAMIDE SYNTHASE; CERAMIDES; CODING REGION; EMBRYONIC STEM CELLS; GRANULAR LAYER; ISOFORMS; MULTIFOCAL; MYELIN BASIC PROTEIN; PERIPHERAL NERVOUS SYSTEM; TISSUE ARCHITECTURE; TRANSGENIC MICE;

ACIDS; AMIDES; CELL MEMBRANES; ENZYMES; FATTY ACIDS; LIVER; NUCLEIC ACIDS;

BRAIN;

BETA GALACTOSIDASE; CERAMIDE SYNTHASE 2; MESSENGER RNA; MYELIN BASIC PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN; CEREBELLUM DEGENERATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; GENE INSERTION; GENE LOCATION; KIDNEY; LIVER; LIVER CELL CARCINOMA; MOUSE; MYELIN SHEATH; NERVE FIBER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RESIDUE ANALYSIS; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CERAMIDES; FEMALE; IMMUNOBLOTTING; KIDNEY; LIVER; LIVER NEOPLASMS; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; OXIDOREDUCTASES; SPHINGOLIPIDS; SPHINGOMYELINS; SPHINGOSINE N-ACYLTRANSFERASE; SPINOCEREBELLAR DEGENERATIONS;

MUS; MUS MUSCULUS;

EID: 70450240715     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.031971     Document Type: Article

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