Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane

Journal of Cell Biology

Volumn 161, Issue 6, 2003, Pages 1117-1131

  Umebayashi, Kyohei ^a,b   Nakano, Akihiko ^a  

^a RIKEN   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

ERG6; Multivesicular body; Raft; Tat2p; Ubiquitin

Indexed keywords

ERGOSTEROL; FUNGAL ENZYME; PROTEIN TAT2P; TRYPTOPHAN; TRYPTOPHAN PERMEASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; ENDOSOME; ENZYME BINDING; GENE MUTATION; GOLGI COMPLEX; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; WILD TYPE; YEAST;

AMINO ACID TRANSPORT SYSTEMS; CELL MEMBRANE; CELLS, CULTURED; ENDOSOMES; ERGOSTEROL; MEMBRANE MICRODOMAINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSPORT VESICLES; TRYPTOPHAN; UBIQUITIN; VACUOLES;

EID: 0038491550     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200303088     Document Type: Article

References (52)

1. Babst, M., D.J. Katzmann, E.J. Estepa-Sabal, T. Meerloo, and S.D. Emr. 2002a. ESCRT-III: an endosome-associated heterooligomeric protein complex required for MVB sorting. Dev. Cell. 3:271-282.
2. Babst, M., D.J. Katzmann, W.B. Snyder, B. Wendland, and S.D. Emr. 2002b. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev. Cell. 3:283-289.
3. Bagnat, M., and K. Simons. 2002. Cell surface polarization during yeast mating. Proc. Natl. Acad. Sci. USA. 99:14183-14188.
4. Bagnat, M., S. Keränen, A. Shevchenko, A. Shevchenko, and K. Simons. 2000. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc. Natl. Acad. Sci. USA. 97:3254-3259.
5. Bagnat, M., A. Chang, and K. Simons. 2001. Plasma membrane proton ATPase Pmalp requires raft association for surface delivery in yeast. Mol. Biol. Cell. 12:4129-4138.
6. Becherer, K.A., S.E. Rieder, S.D. Emr, and E.W. Jones. 1996. Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol. Biol. Cell. 7:579-594.
7. Beck, T., A. Schmidt, and M.N. Hall. 1999. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J. Cell Biol. 146:1227-1237.
8. Daum, G., N.D. Lees, M. Bard, and R. Dickson. 1998. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast. 14:1471-1510.
9. Dimster-Denk, D., M.K. Thorsness, and J. Rine. 1994. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae. Mol. Biol. Cell. 5:655-665.
10. Ellison, M.J., and M. Hochstrasser. 1991. Epitope-tagged ubiquitin. J. Biol. Chem. 266:21150-21157.
11. Gaber, R.F., D.M. Copple, B.K. Kennedy, M. Vidal, and M. Bard. 1989. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 9:3447-3456.
12. Gerrard, S.R., B.P. Levi, and T.H. Stevens. 2000. Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment. Traffic. 1:259-269.
13. Harsay, E., and R. Schekman. 2002. A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway. J. Cell Biol. 156:271-285.
14. Heese-Peck, A., H. Pichler, B. Zanolari, R. Watanabe, G. Daum, and H. Riezman. 2002. Multiple functions of sterols in yeast endocytosis. Mol. Biol. Cell. 13:2664-2680.
15. Helliwell, S.B., S. Losko, and C.A. Kaiser. 2001. Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J. Cell Biol. 153:649-662.
16. Hicke, L., and H. Riezman. 1996. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell. 84:277-287.
17. Hochstrasser, M., M.J. Ellison, V. Chau, and A. Varshavsky. 1991. The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo. Proc Natl. Acad. Sci. USA. 88:4606-4610.
18. Katzmann, D.J., M. Babst, and S.D. Emr. 2001. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-1. Cell. 106:145-155.
19. Kaur, R., and A.K. Bachhawat. 1999. The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. Microbiology. 145:809-818.
20. Kim, Y., C.-W. Yun, and C.C. Philpott. 2002. Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. EMBO J. 21:3632-3642.
21. Lafont, F., and K. Simons. 2001. Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling. Proc. Natl. Acad. Sci. USA. 98:3180-3184.
22. Losko, S., F. Kopp, A. Kranz, and R. Kölling. 2001. Uptake of the ATP-binding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 mutant. Mol. Biol. Cell. 12:1047-1059.
23. McGee, T.P., H.B. Skinner, E.A. Whitters, S.A. Henry, and V.A. Bankaitis. 1994. A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes. J. Cell Biol. 124:273-287.
24. Miwako, I., A. Yamamoto, T. Kitamura, K. Nagayama, and M. Ohashi. 2001. Cholesterol requirement for cation-independent mannose 6-phosphate receptor exit from multivesicular late endosomes to the Golgi. J. Cell Sci. 114:1765-1776.
25. Munn, A.L., A. Heese-Peck, B.J. Stevenson, H. Pichler, and H. Riezman. 1999. Specific sterols required for the internalization step of endocytosis in yeast. Mol. Biol. Cell. 10:3943-3957.
26. Nakano, A., D. Brada, and R. Schekman. 1988. A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast. J. Cell Biol. 107:851-863.
27. Nishikawa, S., and A. Nakano. 1991. The GTP-binding Sar1 protein is localized to the early compartment of the yeast secretory pathway. Biochim. Biophys. Acta. 1093:135-143.
28. Nothwehr, S.F., E. Conibear, and T.H. Stevens. 1995. Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane. J. Cell Biol. 129:35-46.
29. Odorizzi, G., M. Babst, and S.D. Emr. 1998. Fab1p Ptlns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell. 95:847-858.
30. Piper, R.C., A.A. Cooper, H. Yang, and T.H. Stevens. 1995. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J. Cell Biol. 131:603-617.
31. Raiborg, C., K.G. Bache, D.J. Gillooly, I.H. Madshus, E. Stang, and H. Stenmark. 2002. Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat. Cell Biol. 4:394-398.
32. Raths, S., J. Rohrer, F. Crausaz, and H. Riezman. 1993. end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J. Cell Biol. 120:55-65.
33. Reggiori, F., and H.R.B. Pelham. 2001. Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J. 20:5176-5186.
34. Reggiori, F., and H.R.B. Pelham. 2002. A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nat. Cell Biol. 4:117-123.
35. Reggiori, F., M.W. Black, and H.R.B. Pelham. 2000. Polar transmembrane domains target proteins to the interior of the yeast vacuole. Mol. Biol. Cell. 11:3737-3749.
36. Roberg, K.J., N. Rowley, and C.A. Kaiser. 1997. Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae. J. Cell Biol. 137:1469-1482.
37. Sato, M., K. Sato, and A. Nakano. 1996. Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain. J. Cell Biol. 134:279-293.
38. Sato, K., M. Sato, and A. Nakano. 1997. Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins. Proc. Natl. Acad. Sci. USA. 94:9693-9698.
39. Sato, K., M. Sato, and A. Nakano. 2001. Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatmer. J. Cell Biol. 152:935-944.
40. Scheiffele, P., M.G. Roth, and K. Simons. 1997. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16:5501-5508.
41. Schmidt, A., M.N. Hall, and A. Koller. 1994. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol. Cell. Biol. 14:6597-6606.
42. Sherman, F. 1991. Getting starred with yeast. Methods Enzymol. 194:3-21.
43. Sievi, E., T. Suntio, and M. Makarow. 2001. Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi. Traffic. 2:896-907.
44. Sikorski, R.S., and P. Hierer. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics. 122:19-27.
45. Simons, K., and E. Ikonen, 1997. Functional rafts in cell membranes. Nature. 387:569-572.
46. Soerens, O., J.-O. De Craene, and B. André. 2001. Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1. J. Biol. Chem. 276:43949-43957.
47. Stevens, T., B. Esmon, and R. Schekman. 1982. Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Cell. 30:439-448.
48. TerBush, D.R., T. Maurice, D. Roch, and P. Novick. 1996. The Exocyst is a multiprocein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15:6483-6494.
49. Wang, G., J.M. McCaffery, B. Wendland, S. Dupré, R. Haguenauer-Tsapis, and J.M. Huibregrse. 2001. Localization of the Rsp5p ubiquitin-protein ligase at multiple sites wirhin the endocytic pathway. Mol. Cell. Biol. 21:3564-3575.
50. Wiederkehr, A., S. Avaro, C. Prescianocro-Baschong, R. Haguenauer-Tsapis, and H. Riezman. 2000. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling our of an early endosome in Saccharomyces cerevisiae. J. Cell Biol. 149:397-410.
51. Yashiroda, H., T. Oguchi, Y. Yasuda, A. Toh-e, and Y. Kikuchi. 1996. Bull, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae. Mol. Cell Biol. 16:3255-3263.
52. Yashiroda, H., D. Kaida, A. Toh-e, and Y. Kikuchi. 1998. The PY-motif of Bull protein is essential for growth of saccharomyces cerevisiae under various stress conditions. Gene. 225:39-46.