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Volumn 7, Issue 3, 2012, Pages 313-328

Role of autotaxin and lysophosphatidate in cancer progression and resistance to chemotherapy and radiotherapy

Author keywords

ceramides; chemoresistance; lysophosphatidic acid receptors; lysophospholipase D; metastasis; tumor progression

Indexed keywords

AUTOTAXIN; BETA3 INTEGRIN; CERAMIDE; DACTINOMYCIN; DOXORUBICIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID 1; LYSOPHOSPHATIDIC ACID 2; LYSOPHOSPHATIDIC ACID 3; LYSOPHOSPHATIDIC ACID 4; LYSOPHOSPHATIDIC ACID RECEPTOR; PACLITAXEL; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84863846299     PISSN: 17460875     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.12.30     Document Type: Review
Times cited : (13)

References (142)
  • 1
    • 78650510111 scopus 로고    scopus 로고
    • Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance
    • Samadi N, Bekele R, Capatos D, Venkatraman G, Sariahmetoglu M, Brindley DN. Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. Biochimie 93, 61-70 (2011).
    • (2011) Biochimie , vol.93 , pp. 61-70
    • Samadi, N.1    Bekele, R.2    Capatos, D.3    Venkatraman, G.4    Sariahmetoglu, M.5    Brindley, D.N.6
  • 2
    • 0036456916 scopus 로고    scopus 로고
    • Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
    • Yang SY, Lee J, Park CG et al. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin. Exp. Metastasis 19, 603-608 (2002).
    • (2002) Clin. Exp. Metastasis , vol.19 , pp. 603-608
    • Yang, S.Y.1    Lee, J.2    Park, C.G.3
  • 3
    • 0034642507 scopus 로고    scopus 로고
    • Autotaxin (ATX) a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells
    • Nam SW, Clair T, Campo CK, Lee HY, Liotta LA, Stracke ML. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene 19, 241-247 (2000).
    • (2000) Oncogene , vol.19 , pp. 241-247
    • Nam, S.W.1    Clair, T.2    Campo, C.K.3    Lee, H.Y.4    Liotta, L.A.5    Stracke, M.L.6
  • 4
    • 0035884290 scopus 로고    scopus 로고
    • Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor
    • Nam SW, Clair T, Kim YS et al. Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. Cancer Res. 61, 6938-6944 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6938-6944
    • Nam, S.W.1    Clair, T.2    Kim, Y.S.3
  • 5
    • 2342437623 scopus 로고    scopus 로고
    • Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
    • Hama K, Aoki J, Fukaya M et al. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J. Biol. Chem. 279, 17634-17639 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 17634-17639
    • Hama, K.1    Aoki, J.2    Fukaya, M.3
  • 6
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • Umezu-Goto M, Kishi Y, Taira A et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158, 227-233 (2002).
    • (2002) J. Cell Biol. , vol.158 , pp. 227-233
    • Umezu-Goto, M.1    Kishi, Y.2    Taira, A.3
  • 7
    • 0026787698 scopus 로고
    • Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein
    • Stracke ML, Krutzsch HC, Unsworth EJ et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J. Biol. Chem. 267, 2524-2529 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 2524-2529
    • Stracke, M.L.1    Krutzsch, H.C.2    Unsworth, E.J.3
  • 8
    • 0037131366 scopus 로고    scopus 로고
    • Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
    • Tokumura A, Majima E, Kariya Y et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277, 39436-39442 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 39436-39442
    • Tokumura, A.1    Majima, E.2    Kariya, Y.3
  • 9
    • 0031584825 scopus 로고    scopus 로고
    • Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
    • An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231, 619-622 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.231 , pp. 619-622
    • An, S.1    Dickens, M.A.2    Bleu, T.3    Hallmark, O.G.4    Goetzl, E.J.5
  • 10
    • 33947529532 scopus 로고    scopus 로고
    • LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation
    • Lee CW, Rivera R, Dubin AE, Chun J. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. J. Biol. Chem. 282, 4310-4317 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 4310-4317
    • Lee, C.W.1    Rivera, R.2    Dubin, A.E.3    Chun, J.4
  • 11
    • 39749127777 scopus 로고    scopus 로고
    • G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    • Pasternack SM, von Kugelgen I, Aboud KA et al. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat. Genet. 40, 329-334 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 329-334
    • Pasternack, S.M.1    Von Kugelgen, I.2    Aboud, K.A.3
  • 12
    • 67650514340 scopus 로고    scopus 로고
    • Unique ligand selectivity of the GPR92/ LPA5 lysophosphatidate receptor indicates role in human platelet activation
    • Williams JR, Khandoga AL, Goyal P et al. Unique ligand selectivity of the GPR92/ LPA5 lysophosphatidate receptor indicates role in human platelet activation. J. Biol. Chem. 284, 17304-17319 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 17304-17319
    • Williams, J.R.1    Khandoga, A.L.2    Goyal, P.3
  • 13
    • 80052229808 scopus 로고    scopus 로고
    • Non-Edg family LPA receptors: The cutting edge of LPA research
    • Yanagida K, Ishii S. Non-Edg family LPA receptors: the cutting edge of LPA research. J. Biochem. 150, 223-232 (2011).
    • (2011) J. Biochem. , vol.150 , pp. 223-232
    • Yanagida, K.1    Ishii, S.2
  • 14
    • 77954267775 scopus 로고    scopus 로고
    • G protein-coupled receptor 87: A promising opportunity for cancer drug discovery
    • Zhang Y, Scoumanne A, Chen X. G protein-coupled receptor 87: a promising opportunity for cancer drug discovery. Mol. Cell. Pharmacol. 2, 111-116 (2010).
    • (2010) Mol. Cell. Pharmacol. , vol.2 , pp. 111-116
    • Zhang, Y.1    Scoumanne, A.2    Chen, X.3
  • 15
    • 44149111549 scopus 로고    scopus 로고
    • Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor
    • Murakami M, Shiraishi A, Tabata K, Fujita N. Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun. 371, 707-712 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 707-712
    • Murakami, M.1    Shiraishi, A.2    Tabata, K.3    Fujita, N.4
  • 16
    • 33748757239 scopus 로고    scopus 로고
    • Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
    • Tanaka M, Okudaira S, Kishi Y et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem. 281, 25822-25830 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 25822-25830
    • Tanaka, M.1    Okudaira, S.2    Kishi, Y.3
  • 17
    • 14844284989 scopus 로고    scopus 로고
    • Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer
    • Brindley DN. Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J. Cell. Biochem. 92, 900-912 (2004).
    • (2004) J. Cell. Biochem. , vol.92 , pp. 900-912
    • Brindley, D.N.1
  • 18
    • 28544433517 scopus 로고    scopus 로고
    • Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): A multifunctional protein involved in central nervous system development and disease
    • Dennis J, Nogaroli L, Fuss B. Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): a multifunctional protein involved in central nervous system development and disease. J. Neurosci. Res. 82, 737-742 (2005).
    • (2005) J. Neurosci. Res. , vol.82 , pp. 737-742
    • Dennis, J.1    Nogaroli, L.2    Fuss, B.3
  • 19
    • 5644239628 scopus 로고    scopus 로고
    • Phosphodiesterase-I alpha/autotaxin controls cytoskeletal organization and FAK phosphorylation during myelination
    • Fox MA, Alexander JK, Afshari FS, Colello RJ, Fuss B. Phosphodiesterase-I alpha/autotaxin controls cytoskeletal organization and FAK phosphorylation during myelination. Mol. Cell. Neurosci. 27, 140-150 (2004).
    • (2004) Mol. Cell. Neurosci. , vol.27 , pp. 140-150
    • Fox, M.A.1    Alexander, J.K.2    Afshari, F.S.3    Colello, R.J.4    Fuss, B.5
  • 21
    • 0027199023 scopus 로고
    • Hepatic secretion of lysphosphatidylcholine: A novel transport system for polyunsaturated fatty acids and choline
    • Brindley DN. Hepatic secretion of lysphosphatidylcholine: a novel transport system for polyunsaturated fatty acids and choline. J. Nutr. Biochem. 4, 442-449 (1993).
    • (1993) J. Nutr. Biochem. , vol.4 , pp. 442-449
    • Brindley, D.N.1
  • 22
    • 0037073806 scopus 로고    scopus 로고
    • Serum lysophosphatidic acid is produced through diverse phospholipase pathways
    • Aoki J, Taira A, Takanezawa Y et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J. Biol. Chem. 277, 48737-48744 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 48737-48744
    • Aoki, J.1    Taira, A.2    Takanezawa, Y.3
  • 23
    • 57349197956 scopus 로고    scopus 로고
    • S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological tool
    • Ferry G, Moulharat N, Pradere JP et al. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J. Pharmacol. Exp. Ther. 327, 809-819 (2008).
    • (2008) J. Pharmacol. Exp. Ther. , vol.327 , pp. 809-819
    • Ferry, G.1    Moulharat, N.2    Pradere, J.P.3
  • 24
    • 77952173274 scopus 로고    scopus 로고
    • Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation
    • Albers HM, Dong A, van Meeteren LA et al. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc. Natl Acad. Sci. USA 107, 7257-7262 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7257-7262
    • Albers, H.M.1    Dong, A.2    Van Meeteren, L.A.3
  • 25
    • 77953778656 scopus 로고    scopus 로고
    • A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation
    • Gierse J, Thorarensen A, Beltey K et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J. Pharmacol. Exp. Ther. 334, 310-317 (2010).
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 310-317
    • Gierse, J.1    Thorarensen, A.2    Beltey, K.3
  • 26
    • 60549102676 scopus 로고    scopus 로고
    • Autotaxin inhibition: Challenges and progress toward novel anti-cancer agents
    • Parrill AL, Baker DL. Autotaxin inhibition: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med. Chem. 8, 917-923 (2008).
    • (2008) Anticancer Agents Med. Chem. , vol.8 , pp. 917-923
    • Parrill, A.L.1    Baker, D.L.2
  • 27
    • 67649819849 scopus 로고    scopus 로고
    • Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasispromoting enzyme autotaxin
    • Jansen S, Andries M, Derua R, Waelkens E, Bollen M. Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasispromoting enzyme autotaxin. J. Biol. Chem. 284, 14296-14302 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 14296-14302
    • Jansen, S.1    Andries, M.2    Derua, R.3    Waelkens, E.4    Bollen, M.5
  • 28
    • 0028986238 scopus 로고
    • Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
    • Fourcade O, Simon MF, Viode C et al. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 80, 919-927 (1995).
    • (1995) Cell , vol.80 , pp. 919-927
    • Fourcade, O.1    Simon, M.F.2    Viode, C.3
  • 29
    • 33749405209 scopus 로고    scopus 로고
    • Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells
    • Zhao X, Wang D, Zhao Z et al. Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. J. Biol. Chem. 281, 29357-29368 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 29357-29368
    • Zhao, X.1    Wang, D.2    Zhao, Z.3
  • 30
    • 77957850780 scopus 로고    scopus 로고
    • Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development
    • Li H, Zhao Z, Wei G et al. Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development. FASEB J. 24(10), 4103-4116 (2010).
    • (2010) FASEB J. , vol.24 , Issue.10 , pp. 4103-4116
    • Li, H.1    Zhao, Z.2    Wei, G.3
  • 31
    • 84863829296 scopus 로고    scopus 로고
    • Lipid phosphate phosphatases: Their role in lysolipid degradation and cell signaling
    • Hla T, Spiegel S, Moolenaar W, Chun J (Eds). John Wiley and Sons Inc., NY, USA (In Press)
    • Venkatraman G, Brindley DN. Lipid phosphate phosphatases: their role in lysolipid degradation and cell signaling. In: Lysolipid Receptors: Signaling and Biochemistry. Hla T, Spiegel S, Moolenaar W, Chun J (Eds). John Wiley and Sons Inc., NY, USA (2012) (In Press).
    • (2012) Lysolipid Receptors: Signaling and Biochemistry
    • Venkatraman, G.1    Brindley, D.N.2
  • 32
    • 0034650912 scopus 로고    scopus 로고
    • Identification of structurally important domains of lipid phosphate phosphatase-1: Implications for its sites of action
    • Zhang QX, Pilquil CS, Dewald J, Berthiaume LG, Brindley DN. Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action. Biochem. J. 345(Pt 2), 181-184 (2000).
    • (2000) Biochem. J. , vol.345 , Issue.PART. 2 , pp. 181-184
    • Zhang, Q.X.1    Pilquil, C.S.2    Dewald, J.3    Berthiaume, L.G.4    Brindley, D.N.5
  • 33
    • 0033564681 scopus 로고    scopus 로고
    • Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    • Jasinska R, Zhang QX, Pilquil C et al. Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem. J. 340, 677-686 (1999).
    • (1999) Biochem. J. , vol.340 , pp. 677-686
    • Jasinska, R.1    Zhang, Q.X.2    Pilquil, C.3
  • 34
    • 64849095442 scopus 로고    scopus 로고
    • Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo
    • Tomsig JL, Snyder AH, Berdyshev EV et al. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. Biochem. J. 419, 611-618 (2009).
    • (2009) Biochem. J. , vol.419 , pp. 611-618
    • Tomsig, J.L.1    Snyder, A.H.2    Berdyshev, E.V.3
  • 35
    • 66349139391 scopus 로고    scopus 로고
    • Lipid phosphate phosphatases and signaling
    • Brindley DN, Pilquil C. Lipid phosphate phosphatases and signaling. J. Lipid Res. 50(Suppl.), S225-S230 (2009).
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Brindley, D.N.1    Pilquil, C.2
  • 36
    • 33644832772 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics
    • Milstien S, Spiegel S. Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell 9, 148-150 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 148-150
    • Milstien, S.1    Spiegel, S.2
  • 37
    • 70349333252 scopus 로고    scopus 로고
    • Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
    • Sukocheva O, Wang L, Verrier E, Vadas MA, Xia P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 150, 4484-4492 (2009).
    • (2009) Endocrinology , vol.150 , pp. 4484-4492
    • Sukocheva, O.1    Wang, L.2    Verrier, E.3    Vadas, M.A.4    Xia, P.5
  • 38
    • 0027484152 scopus 로고
    • Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase ( fps) transformed fibroblasts
    • Martin A, Gomez-Munoz A, Waggoner DW, Stone JC, Brindley DN. Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase ( fps) transformed fibroblasts. J. Biol. Chem. 268, 23924-23932 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 23924-23932
    • Martin, A.1    Gomez-Munoz, A.2    Waggoner, D.W.3    Stone, J.C.4    Brindley, D.N.5
  • 39
    • 0033709497 scopus 로고    scopus 로고
    • A gonadotropin-releasing hormoneresponsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells
    • Imai A, Furui T, Tamaya T, Mills GB. A gonadotropin-releasing hormoneresponsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells. J. Clin. Endocrinol. Metab. 85, 3370-3375 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3370-3375
    • Imai, A.1    Furui, T.2    Tamaya, T.3    Mills, G.B.4
  • 40
    • 12444267437 scopus 로고    scopus 로고
    • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer
    • Tanyi JL, Hasegawa Y, Lapushin R et al. Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. Clin. Cancer Res. 9, 3534-3545 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 3534-3545
    • Tanyi, J.L.1    Hasegawa, Y.2    Lapushin, R.3
  • 41
    • 0037374562 scopus 로고    scopus 로고
    • The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: Validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer
    • Tanyi JL, Morris AJ, Wolf JK et al. The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Cancer Res. 63, 1073-1082 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1073-1082
    • Tanyi, J.L.1    Morris, A.J.2    Wolf, J.K.3
  • 43
    • 0029910301 scopus 로고    scopus 로고
    • The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein
    • Barila D, Plateroti M, Nobili F et al. The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein. J. Biol. Chem. 271, 29928-29936 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 29928-29936
    • Barila, D.1    Plateroti, M.2    Nobili, F.3
  • 44
    • 0030804654 scopus 로고    scopus 로고
    • Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase
    • Kai M, Wada I, Imai S, Sakane F, Kanoh H. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. J. Biol. Chem. 272, 24572-24578 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24572-24578
    • Kai, M.1    Wada, I.2    Imai, S.3    Sakane, F.4    Kanoh, H.5
  • 45
    • 3242691277 scopus 로고    scopus 로고
    • Lysophosphatidic acid and sphingosine 1-phosphate biology: The role of lipid phosphate phosphatases
    • Pyne S, Kong KC, Darroch PI. Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. Semin. Cell Dev. Biol. 15, 491-501 (2004).
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 491-501
    • Pyne, S.1    Kong, K.C.2    Darroch, P.I.3
  • 46
    • 0035918159 scopus 로고    scopus 로고
    • G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells
    • Alderton F, Darroch P, Sambi B et al. G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. J. Biol. Chem. 276, 13452-13460 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 13452-13460
    • Alderton, F.1    Darroch, P.2    Sambi, B.3
  • 47
    • 33644757800 scopus 로고    scopus 로고
    • Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-and platelet-derived-growth-factor-induced cell migration
    • Long JS, Yokoyama K, Tigyi G, Pyne NJ, Pyne S. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-and platelet-derived-growth- factor-induced cell migration. Biochem. J. 394, 495-500 (2006).
    • (2006) Biochem. J. , vol.394 , pp. 495-500
    • Long, J.S.1    Yokoyama, K.2    Tigyi, G.3    Pyne, N.J.4    Pyne, S.5
  • 48
    • 26844442547 scopus 로고    scopus 로고
    • Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
    • Long J, Darroch P, Wan KF et al. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem. J. 391, 25-32 (2005).
    • (2005) Biochem. J. , vol.391 , pp. 25-32
    • Long, J.1    Darroch, P.2    Wan, K.F.3
  • 49
    • 33845978059 scopus 로고    scopus 로고
    • Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation
    • Pilquil C, Dewald J, Cherney A et al. Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation. J. Biol. Chem. 281, 38418-38429 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 38418-38429
    • Pilquil, C.1    Dewald, J.2    Cherney, A.3
  • 50
    • 0031957196 scopus 로고    scopus 로고
    • Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells
    • Leung DW, Tompkins CK, White T. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. DNA Cell Biol. 17, 377-385 (1998).
    • (1998) DNA Cell Biol. , vol.17 , pp. 377-385
    • Leung, D.W.1    Tompkins, C.K.2    White, T.3
  • 51
    • 32344442744 scopus 로고    scopus 로고
    • Lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction
    • Garcia-Murillas I, Pettitt T, Macdonald E et al. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron 49, 533-546 (2006).
    • (2006) Neuron , vol.49 , pp. 533-546
    • Garcia-Murillas, I.1    Pettitt, T.2    MacDonald, E.3
  • 52
    • 0346996444 scopus 로고    scopus 로고
    • Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level
    • Yue J, Yokoyama K, Balazs L et al. Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. Cell. Signal. 16, 385-399 (2004).
    • (2004) Cell. Signal. , vol.16 , pp. 385-399
    • Yue, J.1    Yokoyama, K.2    Balazs, L.3
  • 53
    • 0032693488 scopus 로고    scopus 로고
    • Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells
    • Sciorra VA, Morris AJ. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. Mol. Biol. Cell 10, 3863-3876 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3863-3876
    • Sciorra, V.A.1    Morris, A.J.2
  • 54
  • 55
    • 0030942087 scopus 로고    scopus 로고
    • Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras-and tyrosine kinase (fps)-transformed fibroblasts
    • Martin A, Duffy PA, Liossis C et al. Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras-and tyrosine kinase (fps)-transformed fibroblasts. Oncogene 14, 1571-1580 (1997).
    • (1997) Oncogene , vol.14 , pp. 1571-1580
    • Martin, A.1    Duffy, P.A.2    Liossis, C.3
  • 56
    • 68949132665 scopus 로고    scopus 로고
    • Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases
    • Brindley D, Pilquil C, Sariahmetoglu M, Reue K. Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Biochim. Biophys. Acta 1791(9), 956-961 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1791 , Issue.9 , pp. 956-961
    • Brindley, D.1    Pilquil, C.2    Sariahmetoglu, M.3    Reue, K.4
  • 57
    • 33646923818 scopus 로고    scopus 로고
    • Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts
    • Morris KE, Schang LM, Brindley DN. Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. J. Biol. Chem. 281, 9297-9306 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 9297-9306
    • Morris, K.E.1    Schang, L.M.2    Brindley, D.N.3
  • 58
    • 23244447037 scopus 로고    scopus 로고
    • BRAFE600-associated senescence-like cell cycle arrest of human naevi
    • Michaloglou C, Vredeveld LC, Soengas MS et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1    Vredeveld, L.C.2    Soengas, M.S.3
  • 59
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 60
    • 0033809110 scopus 로고    scopus 로고
    • Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile
    • Zhang N, Sundberg JP, Gridley T. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Genesis 27, 137-140 (2000).
    • (2000) Genesis , vol.27 , pp. 137-140
    • Zhang, N.1    Sundberg, J.P.2    Gridley, T.3
  • 61
    • 58149492132 scopus 로고    scopus 로고
    • Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
    • Flanagan JM, Funes JM, Henderson S, Wild L, Carey N, Boshoff C. Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets. Mol. Cancer Ther. 8, 249-260 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 249-260
    • Flanagan, J.M.1    Funes, J.M.2    Henderson, S.3    Wild, L.4    Carey, N.5    Boshoff, C.6
  • 63
    • 0242384038 scopus 로고    scopus 로고
    • Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: Nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells
    • Moughal NA, Waters C, Sambi B, Pyne S, Pyne NJ. Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. Cell. Signal. 16, 127-136 (2004).
    • (2004) Cell. Signal. , vol.16 , pp. 127-136
    • Moughal, N.A.1    Waters, C.2    Sambi, B.3    Pyne, S.4    Pyne, N.J.5
  • 64
    • 0141755203 scopus 로고    scopus 로고
    • Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1
    • Gobeil F Jr, Bernier SG, Vazquez-Tello A et al. Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1. J. Biol. Chem. 278, 38875-38883 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 38875-38883
    • Gobeil Jr., F.1    Bernier, S.G.2    Vazquez-Tello, A.3
  • 65
    • 0037422595 scopus 로고    scopus 로고
    • Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    • McIntyre TM, Pontsler AV, Silva AR et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl Acad. Sci. USA 100, 131-136 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 131-136
    • McIntyre, T.M.1    Pontsler, A.V.2    Silva, A.R.3
  • 66
    • 15344341231 scopus 로고    scopus 로고
    • Thrombogenic and atherogenic activities of lysophosphatidic acid
    • Siess W, Tigyi G. Thrombogenic and atherogenic activities of lysophosphatidic acid. J. Cell. Biochem. 92, 1086-1094 (2004).
    • (2004) J. Cell. Biochem. , vol.92 , pp. 1086-1094
    • Siess, W.1    Tigyi, G.2
  • 67
    • 23044459004 scopus 로고    scopus 로고
    • The coordination of prostaglandin E2 production by sphingosine-1- phosphate and ceramide-1-phosphate
    • Pettus BJ, Kitatani K, Chalfant CE et al. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol. Pharmacol. 68, 330-335 (2005).
    • (2005) Mol. Pharmacol. , vol.68 , pp. 330-335
    • Pettus, B.J.1    Kitatani, K.2    Chalfant, C.E.3
  • 69
    • 56649105158 scopus 로고    scopus 로고
    • In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation
    • Taghavi P, Verhoeven E, Jacobs JJ et al. In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation. Oncogene 27, 6806-6816 (2008).
    • (2008) Oncogene , vol.27 , pp. 6806-6816
    • Taghavi, P.1    Verhoeven, E.2    Jacobs, J.J.3
  • 70
    • 79551636074 scopus 로고    scopus 로고
    • Structural basis of substrate discrimination and integrin binding by autotaxin
    • Hausmann J, Kamtekar S, Christodoulou E et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat. Struct. Mol. Biol. 18, 198-204 (2011).
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 198-204
    • Hausmann, J.1    Kamtekar, S.2    Christodoulou, E.3
  • 71
    • 80053131625 scopus 로고    scopus 로고
    • Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells
    • Fulkerson Z, Wu T, Sunakura M, Vander Kooi C, Morris AJ, Smyth SS. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J. Biol. Chem. 286(40), 34654-34663 (2011).
    • (2011) J. Biol. Chem. , vol.286 , Issue.40 , pp. 34654-34663
    • Fulkerson, Z.1    Wu, T.2    Sunakura, M.3    Vander Kooi, C.4    Morris, A.J.5    Smyth, S.S.6
  • 72
    • 80053131258 scopus 로고    scopus 로고
    • Insights into autotaxin: How to produce and present a lipid mediator
    • Moolenaar WH, Perrakis A. Insights into autotaxin: how to produce and present a lipid mediator. Nat. Rev. Mol. Cell Biol. 12, 674-679 (2011).
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 674-679
    • Moolenaar, W.H.1    Perrakis, A.2
  • 73
    • 0025012050 scopus 로고
    • Integrin distribution in malignant melanoma: Association of the beta 3 subunit with tumor progression
    • Albelda SM, Mette SA, Elder DE et al. Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res. 50, 6757-6764 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 6757-6764
    • Albelda, S.M.1    Mette, S.A.2    Elder, D.E.3
  • 74
    • 0031770035 scopus 로고    scopus 로고
    • Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma
    • Hsu MY, Shih DT, Meier FE et al. Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. Am. J. Pathol. 153, 1435-1442 (1998).
    • (1998) Am. J. Pathol. , vol.153 , pp. 1435-1442
    • Hsu, M.Y.1    Shih, D.T.2    Meier, F.E.3
  • 75
    • 70350574674 scopus 로고    scopus 로고
    • An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
    • Desgrosellier JS, Barnes LA, Shields DJ et al. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat. Med. 15, 1163-1169 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1163-1169
    • Desgrosellier, J.S.1    Barnes, L.A.2    Shields, D.J.3
  • 76
    • 49949092545 scopus 로고    scopus 로고
    • Autotaxin (ATX): A multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties
    • Yuelling LM, Fuss B. Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties. Biochim. Biophys. Acta 1781, 525-530 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 525-530
    • Yuelling, L.M.1    Fuss, B.2
  • 77
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 3, 582-591 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 78
  • 79
    • 0029836932 scopus 로고    scopus 로고
    • Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
    • Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135, 1071-1083 (1996).
    • (1996) J. Cell Biol. , vol.135 , pp. 1071-1083
    • Hecht, J.H.1    Weiner, J.A.2    Post, S.R.3    Chun, J.4
  • 80
    • 0032568613 scopus 로고    scopus 로고
    • A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid
    • Fukushima N, Kimura Y, Chun J. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl Acad. Sci. USA 95, 6151-6156 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 6151-6156
    • Fukushima, N.1    Kimura, Y.2    Chun, J.3
  • 81
    • 0034700050 scopus 로고    scopus 로고
    • Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
    • Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl Acad. Sci. USA 97, 13384-13389 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13384-13389
    • Contos, J.J.1    Fukushima, N.2    Weiner, J.A.3    Kaushal, D.4    Chun, J.5
  • 82
    • 56649117552 scopus 로고    scopus 로고
    • Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells
    • Shin KJ, Kim YL, Lee S et al. Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells. J. Cancer Res. Clin. Oncol. 135, 45-52 (2009).
    • (2009) J. Cancer Res. Clin. Oncol. , vol.135 , pp. 45-52
    • Shin, K.J.1    Kim, Y.L.2    Lee, S.3
  • 83
    • 0032478615 scopus 로고    scopus 로고
    • Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
    • An S, Bleu T, Hallmark OG, Goetzl EJ. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273, 7906-7910 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 7906-7910
    • An, S.1    Bleu, T.2    Hallmark, O.G.3    Goetzl, E.J.4
  • 84
    • 0036786445 scopus 로고    scopus 로고
    • Characterization of lpa(2) (Edg4) and lpa(1)/ lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
    • Contos JJ, Ishii I, Fukushima N et al. Characterization of lpa(2) (Edg4) and lpa(1)/ lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol. Cell. Biol. 22, 6921-6929 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6921-6929
    • Contos, J.J.1    Ishii, I.2    Fukushima, N.3
  • 85
    • 2442676625 scopus 로고    scopus 로고
    • NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation
    • Oh YS, Jo NW, Choi JW et al. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol. Cell. Biol. 24, 5069-5079 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 5069-5079
    • Oh, Y.S.1    Jo, N.W.2    Choi, J.W.3
  • 86
    • 38049108069 scopus 로고    scopus 로고
    • The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
    • Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J. Biol. Chem. 282, 37759-37769 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 37759-37769
    • Lin, F.T.1    Lai, Y.J.2    Makarova, N.3    Tigyi, G.4    Lin, W.C.5
  • 87
    • 0033600761 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
    • Bandoh K, Aoki J, Hosono H et al. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274, 27776-27785 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 27776-27785
    • Bandoh, K.1    Aoki, J.2    Hosono, H.3
  • 88
    • 18344397194 scopus 로고    scopus 로고
    • LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    • Ye X, Hama K, Contos JJ et al. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 435, 104-108 (2005).
    • (2005) Nature , vol.435 , pp. 104-108
    • Ye, X.1    Hama, K.2    Contos, J.J.3
  • 89
    • 59449091267 scopus 로고    scopus 로고
    • Role of LPA4/p2y9/GPR23 in negative regulation of cell motility
    • Lee Z, Cheng CT, Zhang H et al. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol. Biol. Cell 19, 5435-5445 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5435-5445
    • Lee, Z.1    Cheng, C.T.2    Zhang, H.3
  • 90
    • 0035871981 scopus 로고    scopus 로고
    • Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: Over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer
    • Schulte KM, Beyer A, Kohrer K, Oberhauser S, Roher HD. Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer. Int. J. Cancer 92, 249-256 (2001).
    • (2001) Int. J. Cancer , vol.92 , pp. 249-256
    • Schulte, K.M.1    Beyer, A.2    Kohrer, K.3    Oberhauser, S.4    Roher, H.D.5
  • 91
    • 37549041384 scopus 로고    scopus 로고
    • Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2
    • Horak CE, Mendoza A, Vega-Valle E et al. Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res. 67, 11751-11759 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 11751-11759
    • Horak, C.E.1    Mendoza, A.2    Vega-Valle, E.3
  • 92
    • 34547616645 scopus 로고    scopus 로고
    • Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    • Horak CE, Lee JH, Elkahloun AG et al. Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Cancer Res. 67, 7238-7246 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 7238-7246
    • Horak, C.E.1    Lee, J.H.2    Elkahloun, A.G.3
  • 93
    • 11844301025 scopus 로고    scopus 로고
    • Overexpression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma
    • Kitayama J, Shida D, Sako A et al. Overexpression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma. Breast Cancer Res. 6, R640-R646 (2004).
    • (2004) Breast Cancer Res. , vol.6
    • Kitayama, J.1    Shida, D.2    Sako, A.3
  • 94
    • 0035897531 scopus 로고    scopus 로고
    • Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells
    • Hu YL, Tee MK, Goetzl EJ et al. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. J. Natl Cancer Inst. 93, 762-768 (2001).
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 762-768
    • Hu, Y.L.1    Tee, M.K.2    Goetzl, E.J.3
  • 95
    • 65649132676 scopus 로고    scopus 로고
    • Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    • Liu S, Umezu-Goto M, Murph M et al. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell 15, 539-550 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 539-550
    • Liu, S.1    Umezu-Goto, M.2    Murph, M.3
  • 96
    • 0027235844 scopus 로고
    • Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D
    • Imamura F, Horai T, Mukai M, Shinkai K, Sawada M, Akedo H. Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D. Biochem. Biophys. Res. Commun. 193, 497-503 (1993).
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 497-503
    • Imamura, F.1    Horai, T.2    Mukai, M.3    Shinkai, K.4    Sawada, M.5    Akedo, H.6
  • 97
    • 58249115241 scopus 로고    scopus 로고
    • Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
    • Scott SA, Selvy PE, Buck JR et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat. Chem. Biol. 5, 108-117 (2009).
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 108-117
    • Scott, S.A.1    Selvy, P.E.2    Buck, J.R.3
  • 98
    • 84867083414 scopus 로고    scopus 로고
    • The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion
    • doi:10.1038/onc.2011.595 Epub ahead of print
    • Jeong KJ, Park SY, Cho KH et al. The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion. Oncogene doi:10.1038/onc.2011.595 (2012) (Epub ahead of print).
    • (2012) Oncogene
    • Jeong, K.J.1    Park, S.Y.2    Cho, K.H.3
  • 99
    • 0942301169 scopus 로고    scopus 로고
    • Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)
    • Huang MC, Lee HY, Yeh CC, Kong Y, Zaloudek CJ, Goetzl EJ. Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2). Oncogene 23, 122-129 (2004).
    • (2004) Oncogene , vol.23 , pp. 122-129
    • Huang, M.C.1    Lee, H.Y.2    Yeh, C.C.3    Kong, Y.4    Zaloudek, C.J.5    Goetzl, E.J.6
  • 100
    • 0035300534 scopus 로고    scopus 로고
    • Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells
    • Fishman DA, Liu Y, Ellerbroek SM, Stack MS. Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells. Cancer Res. 61, 3194-3199 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 3194-3199
    • Fishman, D.A.1    Liu, Y.2    Ellerbroek, S.M.3    Stack, M.S.4
  • 101
    • 84859910759 scopus 로고    scopus 로고
    • Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in threedimensional organotypic models
    • Harma V, Knuuttila M, Virtanen J et al. Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in threedimensional organotypic models. Oncogene 31, 2075-2089 (2011).
    • (2011) Oncogene , vol.31 , pp. 2075-2089
    • Harma, V.1    Knuuttila, M.2    Virtanen, J.3
  • 102
    • 34948857003 scopus 로고    scopus 로고
    • AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells
    • Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. J. Cell. Physiol. 213, 740-749 (2007).
    • (2007) J. Cell. Physiol. , vol.213 , pp. 740-749
    • Dorfleutner, A.1    Stehlik, C.2    Zhang, J.3    Gallick, G.E.4    Flynn, D.C.5
  • 103
    • 0027991902 scopus 로고
    • Lysophosphatidic acid activation of phosphatidylcholinehydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism
    • Ha KS, Yeo EJ, Exton JH. Lysophosphatidic acid activation of phosphatidylcholinehydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism. Biochem. J. 303(Pt 1), 55-59 (1994).
    • (1994) Biochem. J. , vol.303 , Issue.PART. 1 , pp. 55-59
    • Ha, K.S.1    Yeo, E.J.2    Exton, J.H.3
  • 104
    • 53049096639 scopus 로고    scopus 로고
    • Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
    • Shida D, Fang X, Kordula T et al. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 68, 6569-6577 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 6569-6577
    • Shida, D.1    Fang, X.2    Kordula, T.3
  • 105
    • 10744225477 scopus 로고    scopus 로고
    • Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells
    • Fang X, Yu S, Bast RC et al. Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. J. Biol. Chem. 279, 9653-9661 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 9653-9661
    • Fang, X.1    Yu, S.2    Bast, R.C.3
  • 106
    • 8444230395 scopus 로고    scopus 로고
    • Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    • Benoy IH, Salgado R, Van Dam P et al. Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin. Cancer Res. 10, 7157-7162 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7157-7162
    • Benoy, I.H.1    Salgado, R.2    Van Dam, P.3
  • 108
    • 0141757451 scopus 로고    scopus 로고
    • Radiation and ceramide-induced apoptosis
    • Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis. Oncogene 22, 5897-5906 (2003).
    • (2003) Oncogene , vol.22 , pp. 5897-5906
    • Kolesnick, R.1    Fuks, Z.2
  • 110
    • 68349158809 scopus 로고    scopus 로고
    • Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes
    • Martinez R, Navarro R, Lacort M, Ruiz-Sanz JI, Ruiz-Larrea MB. Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes. Toxicol. Lett. 190, 86-90 (2009).
    • (2009) Toxicol. Lett. , vol.190 , pp. 86-90
    • Martinez, R.1    Navarro, R.2    Lacort, M.3    Ruiz-Sanz, J.I.4    Ruiz-Larrea, M.B.5
  • 111
    • 0141864377 scopus 로고    scopus 로고
    • Apoptosis, chemoresistance, and breast cancer: Insights from the MCF-7 cell model system
    • Simstein R, Burow M, Parker A, Weldon C, Beckman B. Apoptosis, chemoresistance, and breast cancer: insights from the MCF-7 cell model system. Exp. Biol. Med. (Maywood) 228, 995-1003 (2003).
    • (2003) Exp. Biol. Med. (Maywood) , vol.228 , pp. 995-1003
    • Simstein, R.1    Burow, M.2    Parker, A.3    Weldon, C.4    Beckman, B.5
  • 112
    • 0033178928 scopus 로고    scopus 로고
    • Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes
    • Delpy E, Hatem SN, Andrieu N et al. Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes. Cardiovasc. Res. 43, 398-407 (1999).
    • (1999) Cardiovasc. Res. , vol.43 , pp. 398-407
    • Delpy, E.1    Hatem, S.N.2    Andrieu, N.3
  • 114
    • 80051509598 scopus 로고    scopus 로고
    • Apoptotic sphingolipid ceramide in cancer therapy
    • Huang WC, Chen CL, Lin YS, Lin CF. Apoptotic sphingolipid ceramide in cancer therapy. J. Lipids 2011, 565316 (2011).
    • (2011) J. Lipids , vol.2011 , pp. 565316
    • Huang, W.C.1    Chen, C.L.2    Lin, Y.S.3    Lin, C.F.4
  • 115
    • 38849095253 scopus 로고    scopus 로고
    • Changes in mitochondrial dynamics during ceramideinduced cardiomyocyte early apoptosis
    • Parra V, Eisner V, Chiong M et al. Changes in mitochondrial dynamics during ceramideinduced cardiomyocyte early apoptosis. Cardiovasc. Res. 77, 387-397 (2008).
    • (2008) Cardiovasc. Res. , vol.77 , pp. 387-397
    • Parra, V.1    Eisner, V.2    Chiong, M.3
  • 116
    • 60549083280 scopus 로고    scopus 로고
    • Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
    • Samadi N, Gaetano C, Goping IS, Brindley DN. Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis. Oncogene 28, 1028-1039 (2009).
    • (2009) Oncogene , vol.28 , pp. 1028-1039
    • Samadi, N.1    Gaetano, C.2    Goping, I.S.3    Brindley, D.N.4
  • 117
    • 0028339322 scopus 로고
    • Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts
    • Gómez-Muñoz A, Martin A, O'Brien L, Brindley DN. Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J. Biol. Chem. 269, 8937-8943 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 8937-8943
    • Gómez-Muñoz, A.1    Martin, A.2    O'brien, L.3    Brindley, D.N.4
  • 118
    • 0028825719 scopus 로고
    • Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity
    • Gómez-Muñoz A, Waggoner DW, O'Brien L, Brindley DN. Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J. Biol. Chem. 270, 26318-26325 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 26318-26325
    • Gómez-Muñoz, A.1    Waggoner, D.W.2    O'brien, L.3    Brindley, D.N.4
  • 119
    • 0035909066 scopus 로고    scopus 로고
    • Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate
    • Singh IN, Stromberg LM, Bourgoin SG, Sciorra VA, Morris AJ, Brindley DN. Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. Biochemistry 40, 11227-11233 (2001).
    • (2001) Biochemistry , vol.40 , pp. 11227-11233
    • Singh, I.N.1    Stromberg, L.M.2    Bourgoin, S.G.3    Sciorra, V.A.4    Morris, A.J.5    Brindley, D.N.6
  • 120
    • 0031012382 scopus 로고    scopus 로고
    • Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA
    • Abousalham A, Liossis C, O'Brien L, Brindley DN. Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA. J. Biol. Chem. 272, 1069-1075 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 1069-1075
    • Abousalham, A.1    Liossis, C.2    O'brien, L.3    Brindley, D.N.4
  • 122
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer 10, 489-503 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 123
    • 33646117016 scopus 로고    scopus 로고
    • Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: The role of sphingosine kinase-1
    • Sukocheva O, Wadham C, Holmes A et al. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J. Cell Biol. 173, 301-310 (2006).
    • (2006) J. Cell Biol. , vol.173 , pp. 301-310
    • Sukocheva, O.1    Wadham, C.2    Holmes, A.3
  • 124
    • 63649132142 scopus 로고    scopus 로고
    • Role of sphingolipids in the cytoplasmic signaling of estrogens
    • Sukocheva O, Wadham C, Xia P. Role of sphingolipids in the cytoplasmic signaling of estrogens. Steroids 74, 562-567 (2009).
    • (2009) Steroids , vol.74 , pp. 562-567
    • Sukocheva, O.1    Wadham, C.2    Xia, P.3
  • 126
    • 61649109244 scopus 로고    scopus 로고
    • Estrogen and progesterone interactive effects in postconfluent MCF-7 cell culture
    • Sukocheva OA, Yang Y, Gierthy JF. Estrogen and progesterone interactive effects in postconfluent MCF-7 cell culture. Steroids 74, 410-418 (2009).
    • (2009) Steroids , vol.74 , pp. 410-418
    • Sukocheva, O.A.1    Yang, Y.2    Gierthy, J.F.3
  • 127
    • 77951214876 scopus 로고    scopus 로고
    • Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
    • Takabe K, Kim RH, Allegood JC et al. Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J. Biol. Chem. 285, 10477-10486 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 10477-10486
    • Takabe, K.1    Kim, R.H.2    Allegood, J.C.3
  • 128
    • 7244250153 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is an intracellular effector of phosphatidic acid
    • Delon C, Manifava M, Wood E et al. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J. Biol. Chem. 279, 44763-44774 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 44763-44774
    • Delon, C.1    Manifava, M.2    Wood, E.3
  • 129
    • 36248947897 scopus 로고    scopus 로고
    • Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells
    • Murph MM, Hurst-Kennedy J, Newton V, Brindley DN, Radhakrishna H. Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells. Mol. Cancer Res. 5, 1201-1211 (2007).
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1201-1211
    • Murph, M.M.1    Hurst-Kennedy, J.2    Newton, V.3    Brindley, D.N.4    Radhakrishna, H.5
  • 130
    • 79953744330 scopus 로고    scopus 로고
    • Requirement of Osteopontin in migration and the protection against Taxol-induced apoptosis via ATX-LPA axis in SGC7901 cells
    • Zhang R, Wang J, Ma S, Huang Z, Zhang G. Requirement of Osteopontin in migration and the protection against Taxol-induced apoptosis via ATX-LPA axis in SGC7901 cells. BMC Cell Biol. 12, 11 (2011).
    • (2011) BMC Cell Biol. , vol.12 , pp. 11
    • Zhang, R.1    Wang, J.2    Ma, S.3    Huang, Z.4    Zhang, G.5
  • 131
    • 67649817281 scopus 로고    scopus 로고
    • Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect
    • Shuyu E, Lai YJ, Tsukahara R et al. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J. Biol. Chem. 284, 14558-14571 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 14558-14571
    • Shuyu, E.1    Lai, Y.J.2    Tsukahara, R.3
  • 132
    • 77949915910 scopus 로고    scopus 로고
    • Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells
    • Vidot S, Witham J, Agarwal R et al. Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells. Cell. Signal. 22, 926-935 (2010).
    • (2010) Cell. Signal. , vol.22 , pp. 926-935
    • Vidot, S.1    Witham, J.2    Agarwal, R.3
  • 133
    • 34247850836 scopus 로고    scopus 로고
    • The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury
    • Deng W, Shuyu E, Tsukahara R et al. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology 132, 1834-1851 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1834-1851
    • Deng, W.1    Shuyu, E.2    Tsukahara, R.3
  • 134
    • 20444471030 scopus 로고    scopus 로고
    • LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2)
    • So J, Wang FQ, Navari J, Schreher J, Fishman DA. LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2). Gynecol. Oncol. 97, 870-878 (2005).
    • (2005) Gynecol. Oncol. , vol.97 , pp. 870-878
    • So, J.1    Wang, F.Q.2    Navari, J.3    Schreher, J.4    Fishman, D.A.5
  • 135
    • 77949703248 scopus 로고    scopus 로고
    • Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factorinduced endothelial cell migration
    • Ptaszynska MM, Pendrak ML, Stracke ML, Roberts DD. Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factorinduced endothelial cell migration. Mol. Cancer Res. 8, 309-321 (2010).
    • (2010) Mol. Cancer Res. , vol.8 , pp. 309-321
    • Ptaszynska, M.M.1    Pendrak, M.L.2    Stracke, M.L.3    Roberts, D.D.4
  • 136
    • 40949146034 scopus 로고    scopus 로고
    • Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells
    • Ptaszynska MM, Pendrak ML, Bandle RW, Stracke ML, Roberts DD. Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells. Mol. Cancer Res. 6, 352-363 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , pp. 352-363
    • Ptaszynska, M.M.1    Pendrak, M.L.2    Bandle, R.W.3    Stracke, M.L.4    Roberts, D.D.5
  • 137
    • 84861037947 scopus 로고    scopus 로고
    • Chemical evolution of autotaxin inhibitors
    • Albers HM, Ovaa H. Chemical evolution of autotaxin inhibitors. Chem. Rev. 112(5), 2593-2603 (2012).
    • (2012) Chem. Rev. , vol.112 , Issue.5 , pp. 2593-2603
    • Albers, H.M.1    Ovaa, H.2
  • 138
    • 67650458524 scopus 로고    scopus 로고
    • Dual activity lysophosphatidic acid receptor pan-antagonist/ autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
    • Zhang H, Xu X, Gajewiak J et al. Dual activity lysophosphatidic acid receptor pan-antagonist/ autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 69, 5441-5449 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5441-5449
    • Zhang, H.1    Xu, X.2    Gajewiak, J.3
  • 139
    • 78649239509 scopus 로고    scopus 로고
    • Autotaxin inhibitors: A perspective on initial medicinal chemistry efforts
    • Parrill AL, Baker DL. Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts. Expert Opin Ther. Pat. 20, 1619-1625 (2010).
    • (2010) Expert Opin Ther. Pat. , vol.20 , pp. 1619-1625
    • Parrill, A.L.1    Baker, D.L.2
  • 140
    • 55749092457 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
    • Saunders LP, Ouellette A, Bandle R et al. Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol. Cancer Ther. 7, 3352-3362 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3352-3362
    • Saunders, L.P.1    Ouellette, A.2    Bandle, R.3
  • 141
    • 79954997189 scopus 로고    scopus 로고
    • Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and antimetastatic activity
    • Gupte R, Patil R, Liu J et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and antimetastatic activity. ChemMedChem 6, 922-935 (2011).
    • (2011) ChemMedChem , vol.6 , pp. 922-935
    • Gupte, R.1    Patil, R.2    Liu, J.3
  • 142
    • 77954321169 scopus 로고    scopus 로고
    • A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
    • Swaney JS, Chapman C, Correa LD et al. A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br. J. Pharmacol. 160, 1699-1713 (2010).
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 1699-1713
    • Swaney, J.S.1    Chapman, C.2    Correa, L.D.3


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