A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 1, 2010, Pages 310-317

  Gierse, James ^a   Thorarensen, Atli ^a   Beltey, Konstantine ^a   Bradshaw Pierce, Erica ^a   Cortes Burgos, Luz ^a   Hall, Troii ^a   Johnston, Amy ^a   Murphy, Michael ^a   Nemirovskiy, Olga ^a   Ogawa, Shinji ^a   Pegg, Lyle ^a   Pelc, Matthew ^a   Prinsen, Michael ^a   Schnute, Mark ^a   Wendling, Jay ^a   Wene, Steve ^a   Weinberg, Robin ^a   Wittwer, Arthur ^a   Zweifel, Ben ^a   Masferrer, Jaime ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LYSOPHOSPHATIDIC ACID; NAPROXEN; PF 8380; UNCLASSIFIED DRUG; 6 [3 (PIPERAZIN 1 YL)PROPANOYL]BENZO[D]OXAZOL 2(3H)ONE; ANTIINFLAMMATORY AGENT; AUTOTAXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYPERALGESIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; AREA UNDER THE CURVE; ARTHRITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG BIOAVAILABILITY; DRUG SCREENING; EX VIVO STUDY; FEMALE; FETUS; FIBROBLAST; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NORMAL HUMAN; PHOSPHOLIPID BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BENZOXAZOLES; CELL LINE; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; HYPERALGESIA; LYSOPHOSPHOLIPIDS; MALE; MICE; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PHOSPHODIESTERASE I; PIPERAZINES; PYROPHOSPHATASES; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS;

EID: 77953778656     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.165845     Document Type: Article

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