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Volumn 2, Issue 3, 2010, Pages 111-116

G Protein-coupled receptor 87: A promising opportunity for cancer drug discovery

Author keywords

Apoptosis; Cancer therapy; DNA damage; G protein coupled receptor 87 (GPR87); p53

Indexed keywords

ANTINEOPLASTIC AGENT; CELL SURFACE PROTEIN; DESLORATADINE; DNA; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 87; G PROTEIN COUPLED RECEPTOR 87 ANTAGONIST; GONADORELIN; GOSERELIN; LEUPRORELIN; LYSOPHOSPHATIDIC ACID RECEPTOR; MEMBRANE PROTEIN; OCTREOTIDE; PROTEIN KINASE B; PROTEIN P53; RANITIDINE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG; VPC 32183; ZANTAX;

EID: 77954267775     PISSN: None     EISSN: 19381247     Source Type: Journal    
DOI: 10.4255/mcpharmacol.10.15     Document Type: Article
Times cited : (31)

References (40)
  • 2
    • 0032504237 scopus 로고    scopus 로고
    • G protein-coupled receptors. I. Diversity of receptor-ligand interactions
    • Ji TH, Grossmann M, Ji I. G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J Biol Chem 1998; 273:17299-302.
    • (1998) J Biol Chem , vol.273 , pp. 17299-17302
    • Ji, T.H.1    Grossmann, M.2    Ji, I.3
  • 3
    • 0035398487 scopus 로고    scopus 로고
    • G-protein-coupled receptors and signaling networks: Emerging paradigms
    • Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001; 22: 368-76.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 368-376
    • Marinissen, M.J.1    Gutkind, J.S.2
  • 4
    • 0028289513 scopus 로고
    • Structure and function of G protein-coupled receptors
    • Strader CD, Fong TM, Tota MR, et al. Structure and function of G protein-coupled receptors. Annu Rev Biochem 1994; 63:101-32.
    • (1994) Annu Rev Biochem , vol.63 , pp. 101-132
    • Strader, C.D.1    Fong, T.M.2    Tota, M.R.3
  • 6
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007; 7: 79-94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 7
    • 0028230817 scopus 로고
    • Expanding horizons for receptors coupled to G proteins: Diversity and disease
    • Coughlin SR. Expanding horizons for receptors coupled to G proteins: diversity and disease. Curr Opin Cell Biol 1994; 6: 191-7.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 191-197
    • Coughlin, S.R.1
  • 8
    • 1542358991 scopus 로고    scopus 로고
    • Inherited diseases involving g proteins and g protein-coupled receptors
    • Spiegel AM, Weinstein LS. Inherited diseases involving g proteins and g protein-coupled receptors. Annu Rev Med 2004; 55: 27-39.
    • (2004) Annu Rev Med , vol.55 , pp. 27-39
    • Spiegel, A.M.1    Weinstein, L.S.2
  • 9
    • 0020524517 scopus 로고
    • Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin
    • Nathans J, Hogness DS. Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin. Cell 1983; 34: 807-14.
    • (1983) Cell , vol.34 , pp. 807-814
    • Nathans, J.1    Hogness, D.S.2
  • 10
    • 33947356279 scopus 로고    scopus 로고
    • G protein coupled receptor structure and activation
    • Kobilka BK. G protein coupled receptor structure and activation. Biochim Biophys Acta 2007; 1768: 794-807.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 794-807
    • Kobilka, B.K.1
  • 11
    • 33748551715 scopus 로고    scopus 로고
    • Cellular and molecular biology of orphan G protein-coupled receptors
    • Oh DY, Kim K, Kwon HB, et al. Cellular and molecular biology of orphan G protein-coupled receptors. Int Rev Cytol 2006; 252: 163-218.
    • (2006) Int Rev Cytol , vol.252 , pp. 163-218
    • Oh, D.Y.1    Kim, K.2    Kwon, H.B.3
  • 12
    • 0037082324 scopus 로고    scopus 로고
    • Target validation of G-protein coupled receptors
    • Wise A, Gearing K, Rees S. Target validation of G-protein coupled receptors. Drug Discov Today 2002; 7: 235-246.
    • (2002) Drug Discov Today , vol.7 , pp. 235-246
    • Wise, A.1    Gearing, K.2    Rees, S.3
  • 13
    • 34447513030 scopus 로고    scopus 로고
    • Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening
    • Eglen RM, Bosse R, Reisine T. Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening. Assay Drug Dev Technol 2007; 5: 425-51
    • (2007) Assay Drug Dev Technol , vol.5 , pp. 425-451
    • Eglen, R.M.1    Bosse, R.2    Reisine, T.3
  • 14
    • 33644662506 scopus 로고    scopus 로고
    • Overexpression of G protein- coupled receptors in cancer cells: Involvement in tumor progression
    • Li S, Huang S, Peng SB. Overexpression of G protein- coupled receptors in cancer cells: involvement in tumor progression. Int J Oncol 2005; 27: 1329-39.
    • (2005) Int J Oncol , vol.27 , pp. 1329-1339
    • Li, S.1    Huang, S.2    Peng, S.B.3
  • 15
    • 0031282001 scopus 로고    scopus 로고
    • Identification of a gene (GPR30) with homology to the G- protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
    • Carmeci C, Thompson DA, Ring HZ, et al. Identification of a gene (GPR30) with homology to the G- protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 1997; 45: 607-17.
    • (1997) Genomics , vol.45 , pp. 607-617
    • Carmeci, C.1    Thompson, D.A.2    Ring, H.Z.3
  • 16
    • 0242339246 scopus 로고    scopus 로고
    • Lysophosphatidic acid is a bioactive mediator in ovarian cancer
    • Fang X, Schummer M, Mao M, et al. Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim Biophys Acta 2002; 1582: 257-64.
    • (2002) Biochim Biophys Acta , vol.1582 , pp. 257-264
    • Fang, X.1    Schummer, M.2    Mao, M.3
  • 17
    • 0027369421 scopus 로고
    • Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
    • Parma J, Duprez L, Van Sande J, et al. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 1993; 365: 649-51.
    • (1993) Nature , vol.365 , pp. 649-651
    • Parma, J.1    Duprez, L.2    van Sande, J.3
  • 18
    • 60549097419 scopus 로고    scopus 로고
    • Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • Gnant M, Mlineritsch B, Schippinger W, et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 2009; 360: 679-91.
    • (2009) N Engl J Med , vol.360 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 19
    • 0035985284 scopus 로고    scopus 로고
    • The clinical role of somatostatin analogues as antineoplastic agents: Much ado about nothing?
    • Hejna M, Schmidinger M, Raderer M. The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing? Ann Oncol 2002; 13: 653-68.
    • (2002) Ann Oncol , vol.13 , pp. 653-668
    • Hejna, M.1    Schmidinger, M.2    Raderer, M.3
  • 20
    • 0035970294 scopus 로고    scopus 로고
    • An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors
    • Wittenberger T, Schaller HC, Hellebrand S. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol 2001; 307: 799-813.
    • (2001) J Mol Biol , vol.307 , pp. 799-813
    • Wittenberger, T.1    Schaller, H.C.2    Hellebrand, S.3
  • 21
    • 0035812313 scopus 로고    scopus 로고
    • Discovery and mapping of ten novel G protein-coupled receptor genes
    • Lee DK, Nguyen T, Lynch KR, et al. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 2001; 275: 83-91.
    • (2001) Gene , vol.275 , pp. 83-91
    • Lee, D.K.1    Nguyen, T.2    Lynch, K.R.3
  • 22
    • 40749096931 scopus 로고    scopus 로고
    • HGPR87 contributes to viability of human tumor cells
    • Glatt S, Halbauer D, Heindl S, et al. hGPR87 contributes to viability of human tumor cells. Int J Cancer 2008; 122: 2008-16.
    • (2008) Int J Cancer , vol.122 , pp. 2008-2016
    • Glatt, S.1    Halbauer, D.2    Heindl, S.3
  • 23
    • 34948889998 scopus 로고    scopus 로고
    • The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor
    • Tabata K, Baba K, Shiraishi A, et al. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun 2007; 363: 861-6.
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 861-866
    • Tabata, K.1    Baba, K.2    Shiraishi, A.3
  • 24
    • 68049123431 scopus 로고    scopus 로고
    • The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress
    • Zhang Y, Qian Y, Lu W, et al. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Res 2009; 69: 6049-56.
    • (2009) Cancer Res , vol.69 , pp. 6049-6056
    • Zhang, Y.1    Qian, Y.2    Lu, W.3
  • 25
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005; 24: 2899-908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 26
    • 2442494895 scopus 로고    scopus 로고
    • The common and distinct target genes of the p53 family transcription factors
    • Harms K, Nozell S, Chen X. The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 2004; 61: 822-42.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 822-842
    • Harms, K.1    Nozell, S.2    Chen, X.3
  • 27
    • 0032567334 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor
    • Cheng Y, Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J Biol Chem 1998; 273: 35008-15.
    • (1998) J Biol Chem , vol.273 , pp. 35008-35015
    • Cheng, Y.1    Lotan, R.2
  • 28
    • 16444374937 scopus 로고    scopus 로고
    • Identification of RAI3 as a therapeutic target for breast cancer
    • Nagahata T, Sato T, Tomura A, et al. Identification of RAI3 as a therapeutic target for breast cancer. Endocr Relat Cancer 2005; 12: 65-73.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 65-73
    • Nagahata, T.1    Sato, T.2    Tomura, A.3
  • 29
    • 20144387435 scopus 로고    scopus 로고
    • Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target
    • Wu Q, Ding W, Mirza A, et al. Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target. J Biol Chem 2005; 280: 12935-43.
    • (2005) J Biol Chem , vol.280 , pp. 12935-12943
    • Wu, Q.1    Ding, W.2    Mirza, A.3
  • 30
    • 0034990172 scopus 로고    scopus 로고
    • P53 down-regulates human bradykinin B1 receptor gene expression
    • Yang X, Taylor L, Polgar P. p53 down-regulates human bradykinin B1 receptor gene expression. J Cell Biochem 2001; 82: 38-45.
    • (2001) J Cell Biochem , vol.82 , pp. 38-45
    • Yang, X.1    Taylor, L.2    Polgar, P.3
  • 31
  • 32
    • 0034685809 scopus 로고    scopus 로고
    • The bradykinin type 2 receptor is a target for p53-mediated transcriptional activation
    • Saifudeen Z, Du H, Dipp S et al. The bradykinin type 2 receptor is a target for p53-mediated transcriptional activation. J Biol Chem 2000; 275: 15557-62.
    • (2000) J Biol Chem , vol.275 , pp. 15557-15562
    • Saifudeen, Z.1    du, H.2    Dipp, S.3
  • 33
    • 20744448978 scopus 로고    scopus 로고
    • Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: Impact on differentiation gene expression
    • Saifudeen Z, Diavolitsis V, Stefkova J, et al. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. J Biol Chem 2005; 280: 23094-102.
    • (2005) J Biol Chem , vol.280 , pp. 23094-23102
    • Saifudeen, Z.1    Diavolitsis, V.2    Stefkova, J.3
  • 34
    • 57149112010 scopus 로고    scopus 로고
    • P63 induces CD4+ T-cell chemoattractant TARC/CCL17 in human epithelial cells
    • Kubo T, Ichimiya S, Tonooka A, et al. p63 induces CD4+ T-cell chemoattractant TARC/CCL17 in human epithelial cells. J Interferon Cytokine Res 2008; 28: 725-32.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 725-732
    • Kubo, T.1    Ichimiya, S.2    Tonooka, A.3
  • 35
    • 36248985545 scopus 로고    scopus 로고
    • G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
    • New DC, Wu K, Kwok AW et al. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J 2007; 274: 6025-36.
    • (2007) FEBS J , vol.274 , pp. 6025-6036
    • New, D.C.1    Wu, K.2    Kwok, A.W.3
  • 36
    • 0033588217 scopus 로고    scopus 로고
    • Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53- mediated, transcriptionally dependent apoptosis
    • Sabbatini P McCormick F. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53- mediated, transcriptionally dependent apoptosis. J Biol Chem 1999; 274: 24263-9.
    • (1999) J Biol Chem , vol.274 , pp. 24263-24269
    • Sabbatini, P.1    McCormick, F.2
  • 37
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci 2001; 98: 11598-603.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 38
    • 0037077230 scopus 로고    scopus 로고
    • Akt enhances Mdm2-mediated ubiquitination and degradation of p53
    • Ogawara Y, Kishishita S, Obata T, et al. Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 2002; 277: 21843-50.
    • (2002) J Biol Chem , vol.277 , pp. 21843-21850
    • Ogawara, Y.1    Kishishita, S.2    Obata, T.3
  • 39
    • 36248947897 scopus 로고    scopus 로고
    • Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells
    • Murph MM, Hurst-Kennedy J, Newton V, et al. Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells. Mol Cancer Res 2007; 5: 1201-11.
    • (2007) Mol Cancer Res , vol.5 , pp. 1201-1211
    • Murph, M.M.1    Hurst-Kennedy, J.2    Newton, V.3
  • 40
    • 74849093027 scopus 로고    scopus 로고
    • Lysophosphatidic acid signaling promotes proliferation, differentiation, and cell survival in rat growth plate chondrocytes
    • Hurst-Kennedy J, Boyan BD, Schwartz Z. Lysophosphatidic acid signaling promotes proliferation, differentiation, and cell survival in rat growth plate chondrocytes. Biochim Biophys Acta 2009; 1793: 836-46.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 836-846
    • Hurst-Kennedy, J.1    Boyan, B.D.2    Schwartz, Z.3


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