Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes

Toxicology Letters

Volumn 190, Issue 1, 2009, Pages 86-90

  Martínez, Rosa ^a   Navarro, Rosaura ^a   Lacort, Mercedes ^a   Ruiz Sanz, José Ignacio ^a   Ruiz Larrea, M Begoña ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Ceramide; Diacylglycerol acyltransferase; Doxorubicin; Rat hepatocytes; Sphingomyelin metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CERAMIDE; DIACYLGLYCEROL; DIACYLGLYCEROL ACYLTRANSFERASE; DOXORUBICIN; GLUTATHIONE; MALONALDEHYDE; OLEIC ACID; PHOSPHOLIPID; SPHINGOMYELIN; TRIACYLGLYCEROL; TRITIUM;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG RESPONSE; INHIBITION KINETICS; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELLS, CULTURED; CERAMIDES; DIGLYCERIDES; DOXORUBICIN; GLUTATHIONE; HEPATOCYTES; LIPID METABOLISM; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 68349158809     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.010     Document Type: Article

References (20)

1. Carrasco M.P., Segovia J.L., and Marco C. Incorporation of exogenous precursors into neutral lipids and phospholipids in rat hepatocytes: effect of ethanol in vitro. Biochem. Pharmacol. 56 (1998) 1639-1644
2. Chen H.C., and Farese Jr. R.V. DGAT and triglyceride synthesis: a new target for obesity treatment?. Trends Cardiovasc. Med. 10 (2000) 188-192
3. Fast D.G., and Vance D.E. Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretion. Biochim. Biophys. Acta 1258 (1995) 159-168
4. Gewirtz D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57 (1999) 727-741
5. Gomez-Munoz A., Waggoner D.W., O'Brien L., and Brindley D.N. Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J. Biol. Chem. 270 (1995) 26318-26325
6. Grazide S., Terrisse A.D., Lerouge S., Laurent G., and Jaffrezou J.P. Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines. J. Biol. Chem. 279 (2004) 18256-18261
7. Lamb R.G., Koch J.C., and Bush S.R. An enzymatic explanation of the differential effects of oleate and gemfibrozil on cultured hepatocyte triacylglycerol and phosphatidylcholine biosynthesis and secretion. Biochim. Biophys. Acta 1165 (1993) 299-305
8. Liu Y.Y., Yu J.Y., Yin D., Patwardhan G.A., Gupta V., Hirabayashi Y., Holleran W.M., Giuliano A.E., Jazwinski S.M., Gouaze-Andersson V., Consoli D.P., and Cabot M.C. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 22 (2008) 2541-2551
9. Martinez R., Lacort M., Ruiz-Sanz J.I., and Ruiz-Larrea M.B. Ferrylmyoglobin impairs secretion of VLDL triacylglycerols from stored intracellular pools: involvement of lipid peroxidation. Biochim. Biophys. Acta 1771 (2007) 590-599
10. Martinez R., Navarro R., Martin C., Aurrekoetxea I., Hernandez M.L., Lacort M., Ruiz-Sanz J.I., and Ruiz-Larrea M.B. Doxorubicin increases intracellular diacylglycerol by the mobilization of choline-enriched phospholipids in rat hepatocytes. Ann. N. Y. Acad. Sci. 973 (2002) 49-51
11. Martinez R., Navarro R., Martin C., Aurrekoetxea I., Hernandez M.L., Lacort M., Ruiz-Sanz J.I., and Ruiz-Larrea M.B. Intracellular diacylglycerol accumulation induced by doxorubicin in rat hepatocytes: potential involvement of phospholipases C and D. Ann. N. Y. Acad. Sci. 973 (2002) 52-56
12. Martinez R., Quintana K., Navarro R., Martin C., Hernandez M.L., Aurrekoetxea I., Ruiz-Sanz J.I., Lacort M., and Ruiz-Larrea M.B. Pro-oxidant and antioxidant potential of catecholestrogens against ferrylmyoglobin-induced oxidative stress. Biochim. Biophys. Acta 1583 (2002) 167-175
13. Minotti G., Menna P., Salvatorelli E., Cairo G., and Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56 (2004) 185-229
14. Navarro R., Martinez R., Busnadiego I., Ruiz-Larrea M.B., and Ruiz-Sanz J.I. Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage. Ann. N. Y. Acad. Sci. 1090 (2006) 408-418
15. Reynolds C.P., Maurer B.J., and Kolesnick R.N. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett. 206 (2004) 169-180
16. Ruiz-Larrea M.B., Garrido M.J., and Lacort M. Estradiol-induced effects on glutathione metabolism in rat hepatocytes. J. Biochem. 113 (1993) 563-567
17. Son J.H., Yoo H.H., and Kim D.H. Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. J. Toxicol. Env. Health Part A 70 (2007) 1310-1318
18. Steinbrecher U.P., Gomez-Munoz A., and Duronio V. Acid sphingomyelinase in macrophage apoptosis. Curr. Opin. Lipidol. 15 (2004) 531-537
19. Verkade H.J., Fast D.G., Rusinol A.E., Scraba D.G., and Vance D.E. Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver. J. Biol. Chem. 268 (1993) 24990-24996
20. Won J.S., and Singh I. Sphingolipid signaling and redox regulation. Free Radic. Biol. Med. 40 (2006) 1875-1888