Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 1, 2009, Pages 45-52

  Shin, Kum Joo ^a   Kim, You Lim ^b   Lee, Sukmook ^a   Kim, Dong Kyu ^b   Ahn, Curie ^a   Chung, Junho ^a   Seong, Jae Young ^b   Hwang, Jong Ik ^b  

^a Seoul National University   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

Colony scattering; Gastrointestinal carcinomas; Lentivirus; Lysophosphatidic acid; shRNA

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; LENTIVIRUS VECTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SHORT HAIRPIN RNA;

ARTICLE; CANCER CELL; CELL ACTIVITY; CELL STIMULATION; COLONY FORMING CELL; DIGESTIVE SYSTEM CANCER; DOWN REGULATION; HUMAN; HUMAN CELL; LENTIVIRINAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIRUS EXPRESSION;

BLOTTING, WESTERN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GASTROINTESTINAL NEOPLASMS; HUMANS; LENTIVIRUS; LYSOPHOSPHOLIPIDS; RECEPTORS, LYSOPHOSPHATIDIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 56649117552     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-008-0441-z     Document Type: Article

References (28)

1. B Anliker J Chun 2004 Lysophospholipid G protein-coupled receptors J Biol Chem 279 20555 20558
2. Y Daaka 2002 Mitogenic action of LPA in prostate Biochim Biophys Acta 1582 265 269
3. T Dull R Zufferey M Kelly RJ Mandel M Nguyen D Trono L Naldini 1998 A third-generation lentivirus vector with a conditional packaging system J Virol 72 8463 8471
4. EJ Goetzl S An 1998 Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate FASEB J 12 1589 1598
5. K Hama J Aoki M Fukaya Y Kishi T Sakai R Suzuki H Ohta T Yamori M Watanabe J Chun H Arai 2004 Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1 J Biol Chem 279 17634 17639
6. F Hao M Tan X Xu J Han DD Miller G Tigyi MZ Cui 2007 Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha Biochim Biophys Acta 1771 883 892
7. Huang RY, Wang SM, Hsieh CY, Wu JC (2008) Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin. Int J Cancer (in press)
8. MA Huber N Kraut H Beug 2005 Molecular requirements for epithelial-mesenchymal transition during tumor progression Curr Opin Cell Biol 17 548 558
9. JI Hwang ID Fraser S Choi XF Qin MI Simon 2004 Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA Proc Natl Acad Sci USA 101 488 493
10. I Ishii N Fukushima X Ye J Chun 2004 Lysophospholipid receptors: signaling and biology Annu Rev Biochem 73 321 354
11. J Jourquin N Yang Y Kam C Guess V Quaranta 2006 Dispersal of epithelial cancer cell colonies by lysophosphatidic acid (LPA) J Cell Physiol 206 337 346
12. S Khurana A Tomar SP George Y Wang MR Siddiqui H Guo G Tigyi S Mathew 2008 Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia Exp Cell Res 314 530 542
13. L Larue A Bellacosa 2005 Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways Oncogene 24 7443 7454
14. CW Lee R Rivera S Gardell AE Dubin J Chun 2006 GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5 J Biol Chem 281 23589 23597
15. IS Long K Han M Li S Shirasawa T Sasazuki M Johnston MS Tsao 2003 Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo Mol Cancer Res 1 393 401
16. GB Mills WH Moolenaar 2003 The emerging role of lysophosphatidic acid in cancer Nat Rev Cancer 3 582 591
17. GB Mills C May M Hill S Campbell P Shaw A Marks 1990 Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells J Clin Invest 86 851 855
18. WH Moolenaar 1995 Lysophosphatidic acid, a multifunctional phospholipid messenger J Biol Chem 270 12949 12952
19. BH Shah AJ Baukal FB Shah KJ Catt 2005 Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor Mol Endocrinol 19 2535 2548
20. D Shida J Kitayama H Yamaguchi Y Okaji NH Tsuno T Watanabe Y Takuwa H Nagawa 2003 Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1 Cancer Res 63 1706 1711
21. JP Thiery 2002 Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 442 454
22. A Tokumura E Majima Y Kariya K Tominaga K Kogure K Yasuda K Fukuzawa 2002 Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase J Biol Chem 277 39436 39442
23. M Umezu-Goto Y Kishi A Taira K Hama N Dohmae K Takio T Yamori GB Mills K Inoue J Aoki H Arai 2002 Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production J Cell Biol 158 227 233
24. Y Xie TC Gibbs YV Mukhin KE Meier 2002 Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells J Biol Chem 277 32516 32526
25. Y Xu Z Shen DW Wiper M Wu RE Morton P Elson AW Kennedy J Belinson M Markman G Casey 1998 Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers Jama 280 719 723
26. M Yang WW Zhong N Srivastava A Slavin J Yang T Hoey S An 2005 G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway Proc Natl Acad Sci USA 102 6027 6032
27. JK Yee T Friedmann JC Burns 1994 Generation of high-titer pseudotyped retroviral vectors with very broad host range Methods Cell Biol 43 Pt A 99 112
28. CC Yun H Sun D Wang R Rusovici A Castleberry RA Hall H Shim 2005 LPA2 receptor mediates mitogenic signals in human colon cancer cells Am J Physiol Cell Physiol 289 C2 C11