Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes

Journal of Immunology

Volumn 168, Issue 1, 2002, Pages 44-50

  Ravasi, T ^a   Wells, C ^a   Forrest, A ^a   Underhill, D M ^a   Wainwright, B J ^a   Aderem, A ^a   Grimmond, S ^a   Hume, D A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; CELL HETEROGENEITY; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HOST RESISTANCE; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0036134881     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.1.44     Document Type: Article

References (33)

1. Toll-like receptors in the induction of the innate immune response
2. Endotoxin signal transduction in macrophages
3. The transcriptional program in the response of human fibroblasts to serum
4. Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression
5. Mechanisms of regulation of the MacMARCKS gene in macrophages by bacterial lipopolysaccharide
6. Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig
7. Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages: Demonstration of a novel pattern of responsiveness to bacterial endotoxin
8. Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
9. Contribution of clonally distinct subpopulations to heterogeneous production of inducible nitric oxide synthase by LPS-stimulated mouse macrophages
10. M-1/M-2 macrophages and the Th1/Th2 paradigm
11. Heterogeneity among human mononuclear phagocytes in their secretion of lysozyme, interleukin 1 and type-β transforming growth factor: A quantitative analysis at the single-cell level
12. Macrophage heterogeneity occurs through a developmental mechanism
13. Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development
14. The NF-βA-binding element, not an overlapping NF-IL-6-binding element, is required for maximal IL-1/β gene expression
15. Regulation of interteukin 12 p40 expression through an NF-κB half-site
16. Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor α-induced expression
17. Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor
18. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
19. Muscle differentiation: More complexity to the network of myogenic regulators
20. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5
21. NK-2 homeobox genes and heart development
22. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
23. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
24. Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription
25. Other functions, other genes: Alternative activation of antigen-presenting cells
26. + T cells correlates with Th1/Th2 phenotype
27. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells
28. The Ity/Lsh/Bcg locus: Natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene
29. Interferon-γ and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages
30. 169)-transfected RAW264.7 macrophage cell line
31. 169
32. +/bivalent cation antiporter
33. Macrophages exposed continuously to lipopolysaccharide and other agonists that act via Toll-like receptors exhibit a sustained and additive activation state