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Volumn 4, Issue , 2008, Pages

Finding multiple target optimal intervention in disease-related molecular network

Author keywords

Anti inflammatory; Arachidonic acid metabolic network; Drug efficacy prediction; Multiple target drug design; Network based drug design

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; INDOMETACIN; LICOFELONE; MELOXICAM; NAPROXEN; NIMESULIDE; PARACETAMOL; ROFECOXIB;

EID: 55549101279     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2008.60     Document Type: Article
Times cited : (165)

References (63)
  • 2
    • 44049094845 scopus 로고    scopus 로고
    • Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
    • Ahren B (2008) Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin. Vasc Health Risk Manag 4: 383-394
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 383-394
    • Ahren, B.1
  • 3
    • 1242342177 scopus 로고    scopus 로고
    • Licofelone - clinical update on a novel LOX/ COX inhibitor for the treatment of osteoarthritis
    • Alvaro-Gracia JM (2004) Licofelone - clinical update on a novel LOX/ COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford) 43 (Suppl. 1): i21-i25
    • (2004) Rheumatology (Oxford) , vol.43 , Issue.SUPPL. 1
    • Alvaro-Gracia, J.M.1
  • 4
    • 12344255620 scopus 로고    scopus 로고
    • Predicting the risk for gastrointestinal toxicity in patients taking NSAIDs: The Gastrointestinal Toxicity Survey
    • Ambegaonkar A, Livengood K, Craig T, Day D (2004) Predicting the risk for gastrointestinal toxicity in patients taking NSAIDs: the Gastrointestinal Toxicity Survey. Adv Ther 21: 288-300
    • (2004) Adv Ther , vol.21 , pp. 288-300
    • Ambegaonkar, A.1    Livengood, K.2    Craig, T.3    Day, D.4
  • 5
    • 0018088987 scopus 로고
    • Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase
    • Anderson MW, Crutchley DJ, Tainer BE, Eling TE (1978) Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. Prostaglandins 16: 563-570
    • (1978) Prostaglandins , vol.16 , pp. 563-570
    • Anderson, M.W.1    Crutchley, D.J.2    Tainer, B.E.3    Eling, T.E.4
  • 6
    • 35748935235 scopus 로고    scopus 로고
    • Proteins, drug targets and the mechanisms they control: The simple truth about complex networks
    • Araujo RP, Liotta LA, Petricoin EF (2007) Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nat Rev Drug Discov 6: 871-880
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 871-880
    • Araujo, R.P.1    Liotta, L.A.2    Petricoin, E.F.3
  • 8
    • 0037443567 scopus 로고    scopus 로고
    • Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE])
    • Bays HE, Dujovne CA, McGovern ME, White TE, Kashyap ML, Hutcheson AG, Crouse JR (2003) Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]). Am J Cardiol 91: 667-672
    • (2003) Am J Cardiol , vol.91 , pp. 667-672
    • Bays, H.E.1    Dujovne, C.A.2    McGovern, M.E.3    White, T.E.4    Kashyap, M.L.5    Hutcheson, A.G.6    Crouse, J.R.7
  • 9
    • 2342496237 scopus 로고    scopus 로고
    • The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: Results from a randomized, controlled trial
    • Bias P, Buchner A, Klesser B, Laufer S (2004) The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. Am J Gastroenterol 99: 611-618
    • (2004) Am J Gastroenterol , vol.99 , pp. 611-618
    • Bias, P.1    Buchner, A.2    Klesser, B.3    Laufer, S.4
  • 12
    • 0032579897 scopus 로고    scopus 로고
    • Use and benefits of nonsteroidal anti-inflammatory drugs
    • discussion 21S-22S
    • Brooks P (1998) Use and benefits of nonsteroidal anti-inflammatory drugs. Am J Med 104: 9S-13S; discussion 21S-22S
    • (1998) Am J Med , vol.104
    • Brooks, P.1
  • 13
    • 0345244848 scopus 로고    scopus 로고
    • Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity
    • Camacho M, Lopez-Belmonte J, Vila L (1998) Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Circ Res 83: 353-365
    • (1998) Circ Res , vol.83 , pp. 353-365
    • Camacho, M.1    Lopez-Belmonte, J.2    Vila, L.3
  • 14
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multi-target drugs: The network approach might help drug design
    • Csermely P, Agoston V, Pongor S (2005) The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol Sci 26: 178-182
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 16
    • 4344635632 scopus 로고    scopus 로고
    • mPGES-1 as a novel target for arthritis
    • Fahmi H (2004) mPGES-1 as a novel target for arthritis. Curr Opin Rheumatol 16: 623-627
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 623-627
    • Fahmi, H.1
  • 18
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • Frantz S (2005) Drug discovery: playing dirty. Nature 437: 942-943
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 20
    • 0036124116 scopus 로고    scopus 로고
    • Lovastatin and extended-release niacin combination product: The first drug combination for the management of hyperlipidemia
    • Gupta EK, Ito MK (2002) Lovastatin and extended-release niacin combination product: the first drug combination for the management of hyperlipidemia. Heart Dis 4: 124-137
    • (2002) Heart Dis , vol.4 , pp. 124-137
    • Gupta, E.K.1    Ito, M.K.2
  • 21
    • 10944253095 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis
    • Haeggstrom JZ (2004) Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. J Biol Chem 279: 50639-50642
    • (2004) J Biol Chem , vol.279 , pp. 50639-50642
    • Haeggstrom, J.Z.1
  • 22
    • 0019798097 scopus 로고
    • Prostacyclin: A potent antimetastatic agent
    • Honn KV, Cicone B, Skoff A (1981) Prostacyclin: a potent antimetastatic agent. Science 212: 1270-1272
    • (1981) Science , vol.212 , pp. 1270-1272
    • Honn, K.V.1    Cicone, B.2    Skoff, A.3
  • 24
    • 54349093738 scopus 로고    scopus 로고
    • Hwang WC, Zhang A, Ramanathan M (2008) Identification of information flow-modulating drug targets: a novel bridging paradigm for drug discovery. Clin Pharmacol Ther (advance online publication, 9 July 2008; doi:10.1038/clpt.2008.129)
    • Hwang WC, Zhang A, Ramanathan M (2008) Identification of information flow-modulating drug targets: a novel bridging paradigm for drug discovery. Clin Pharmacol Ther (advance online publication, 9 July 2008; doi:10.1038/clpt.2008.129)
  • 25
    • 2442704469 scopus 로고    scopus 로고
    • Prostaglandin E2 as a mediator of fever: Synthesis and catabolism
    • Ivanov AI, Romanovsky AA (2004) Prostaglandin E2 as a mediator of fever: synthesis and catabolism. Front Biosci 9: 1977-1993
    • (2004) Front Biosci , vol.9 , pp. 1977-1993
    • Ivanov, A.I.1    Romanovsky, A.A.2
  • 26
    • 33847377573 scopus 로고    scopus 로고
    • A robustness-based approach to systems-oriented drug design
    • Kitano H (2007) A robustness-based approach to systems-oriented drug design. Nat Rev Drug Discov 6: 202-210
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 202-210
    • Kitano, H.1
  • 30
    • 33644854745 scopus 로고    scopus 로고
    • COX-2 inhibitors and the risk for cardiovascular events: A re-evaluation of the data and proposed mechanisms
    • Kusmak JM (2005) COX-2 inhibitors and the risk for cardiovascular events: a re-evaluation of the data and proposed mechanisms. SDJ Med 58: 269-272
    • (2005) SDJ Med , vol.58 , pp. 269-272
    • Kusmak, J.M.1
  • 31
    • 0024473347 scopus 로고
    • Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis - effect of low-dose aspirin
    • Kyrle PA, Minar E, Brenner B, Eichler HG, Heistinger M, Marosi L, Lechner K (1989) Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis - effect of low-dose aspirin. Thromb Haemost 61: 374-377
    • (1989) Thromb Haemost , vol.61 , pp. 374-377
    • Kyrle, P.A.1    Minar, E.2    Brenner, B.3    Eichler, H.G.4    Heistinger, M.5    Marosi, L.6    Lechner, K.7
  • 32
    • 0029028067 scopus 로고
    • Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
    • Larder BA, Kemp SD, Harrigan PR (1995) Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 269: 696-699
    • (1995) Science , vol.269 , pp. 696-699
    • Larder, B.A.1    Kemp, S.D.2    Harrigan, P.R.3
  • 35
    • 0029894215 scopus 로고    scopus 로고
    • Dose-related effects of low dose aspirin on hemostasis parameters and prostacyclin/thromboxane ratios in late pregnancy
    • Martin C, Varner MW, Branch DW, Rodgers G, Mitchell MD (1996) Dose-related effects of low dose aspirin on hemostasis parameters and prostacyclin/thromboxane ratios in late pregnancy. Prostaglandins 51: 321-330
    • (1996) Prostaglandins , vol.51 , pp. 321-330
    • Martin, C.1    Varner, M.W.2    Branch, D.W.3    Rodgers, G.4    Mitchell, M.D.5
  • 36
    • 0035110231 scopus 로고    scopus 로고
    • Advair: Combination treatment with fluticasone propionate/salmeterol in the treatment of asthma
    • Nelson HS (2001) Advair: combination treatment with fluticasone propionate/salmeterol in the treatment of asthma. J Allergy Clin Immunol 107: 398-416
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 398-416
    • Nelson, H.S.1
  • 37
    • 0027173720 scopus 로고
    • Model complexity has a significant effect on the numerical value and interpretation of metabolic sensitivity coefficients
    • Palsson BO, Lee ID (1993) Model complexity has a significant effect on the numerical value and interpretation of metabolic sensitivity coefficients. J Theor Biol 161: 299-315
    • (1993) J Theor Biol , vol.161 , pp. 299-315
    • Palsson, B.O.1    Lee, I.D.2
  • 38
    • 11044227348 scopus 로고    scopus 로고
    • Automated oncogene detection in complex protein networks with applications to the MAPK signal transduction pathway
    • Pant D, Ghosh A (2005) Automated oncogene detection in complex protein networks with applications to the MAPK signal transduction pathway. Biophys Chem 113: 275-288
    • (2005) Biophys Chem , vol.113 , pp. 275-288
    • Pant, D.1    Ghosh, A.2
  • 39
    • 0034946873 scopus 로고    scopus 로고
    • Cyclooxygenase- selective inhibition of prostanoid formation: Transducing biochemical selectivity into clinical read-outs
    • Patrono C, Patrignani P, Garcia Rodriguez LA (2001) Cyclooxygenase- selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. J Clin Invest 108: 7-13
    • (2001) J Clin Invest , vol.108 , pp. 7-13
    • Patrono, C.1    Patrignani, P.2    Garcia Rodriguez, L.A.3
  • 41
    • 4444301119 scopus 로고    scopus 로고
    • Is nimesulide safe in a cardiovascular- compromised patient
    • Rahman SZ, Khan RA (2004) Is nimesulide safe in a cardiovascular- compromised patient. Indian J Pharmacol 36: 252-253
    • (2004) Indian J Pharmacol , vol.36 , pp. 252-253
    • Rahman, S.Z.1    Khan, R.A.2
  • 42
    • 0027236493 scopus 로고
    • Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage
    • Spec no
    • Rainsford KD (1993) Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. Agents Actions 39 (Spec no.): C24-C26
    • (1993) Agents Actions , vol.39
    • Rainsford, K.D.1
  • 44
    • 33748455485 scopus 로고    scopus 로고
    • The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit
    • Rotondo S, Dell'Elba G, Manarini S, Cerletti C, Evangelista V (2006) The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit. Eur J Pharmacol 546: 95-101
    • (2006) Eur J Pharmacol , vol.546 , pp. 95-101
    • Rotondo, S.1    Dell'Elba, G.2    Manarini, S.3    Cerletti, C.4    Evangelista, V.5
  • 45
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • Sams-Dodd F (2005) Target-based drug discovery: is something wrong? Drug Discov Today 10: 139-147
    • (2005) Drug Discov Today , vol.10 , pp. 139-147
    • Sams-Dodd, F.1
  • 46
    • 34748817976 scopus 로고    scopus 로고
    • Membrane prostaglandin E synthase-1: A novel therapeutic target
    • Samuelsson B, Morgenstern R, Jakobsson PJ (2007) Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol Rev 59: 207-224
    • (2007) Pharmacol Rev , vol.59 , pp. 207-224
    • Samuelsson, B.1    Morgenstern, R.2    Jakobsson, P.J.3
  • 47
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • Schoeberl B, Eichler-Jonsson C, Gilles ED, Muller G (2002) Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol 20: 370-375
    • (2002) Nat Biotechnol , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 48
    • 0021150830 scopus 로고
    • Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes
    • Shak S, Goldstein IM (1984) Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. J Biol Chem 259: 10181-10187
    • (1984) J Biol Chem , vol.259 , pp. 10181-10187
    • Shak, S.1    Goldstein, I.M.2
  • 50
    • 23944484940 scopus 로고    scopus 로고
    • Genetic diversity and new therapeutic concepts
    • Shastry BS (2005) Genetic diversity and new therapeutic concepts. J Hum Genet 50: 321-328
    • (2005) J Hum Genet , vol.50 , pp. 321-328
    • Shastry, B.S.1
  • 51
    • 0020645206 scopus 로고
    • The release of leukotriene B4 during experimental inflammation
    • Simmons PM, Salmon JA, Moncada S (1983) The release of leukotriene B4 during experimental inflammation. Biochem Pharmacol 32: 1353-1359
    • (1983) Biochem Pharmacol , vol.32 , pp. 1353-1359
    • Simmons, P.M.1    Salmon, J.A.2    Moncada, S.3
  • 52
    • 4944229572 scopus 로고    scopus 로고
    • Merck withdraws arthritis drug worldwide
    • Singh D (2004) Merck withdraws arthritis drug worldwide. BMJ 329: 816
    • (2004) BMJ , vol.329 , pp. 816
    • Singh, D.1
  • 53
    • 0019123930 scopus 로고
    • Thromboxane A2, prostacyclin and aspirin: Effects on vascular tone and platelet aggregation
    • Smith JB, Araki H, Lefer AM (1980) Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation. Circulation 62: V19-V25
    • (1980) Circulation , vol.62
    • Smith, J.B.1    Araki, H.2    Lefer, A.M.3
  • 55
    • 34548125720 scopus 로고    scopus 로고
    • Anti-inflammatory and side effects of cyclooxygenase inhibitors
    • Suleyman H, Demircan B, Karagoz Y (2007) Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep 59: 247-258
    • (2007) Pharmacol Rep , vol.59 , pp. 247-258
    • Suleyman, H.1    Demircan, B.2    Karagoz, Y.3
  • 56
    • 0033996199 scopus 로고    scopus 로고
    • NSAID induced gastric mucosal damage and its prevention in rats
    • Sun B, Li Z (2000) NSAID induced gastric mucosal damage and its prevention in rats. World Chin J Digest 8: 271-275
    • (2000) World Chin J Digest , vol.8 , pp. 271-275
    • Sun, B.1    Li, Z.2
  • 57
    • 3042668006 scopus 로고    scopus 로고
    • In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics
    • Sung MH, Simon R (2004) In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics. Mol Pharmacol 66: 70-75
    • (2004) Mol Pharmacol , vol.66 , pp. 70-75
    • Sung, M.H.1    Simon, R.2
  • 60
    • 15044348210 scopus 로고    scopus 로고
    • Cardiovascular hazard and non-steroidal anti-inflammatory drugs
    • Wang D, Wang M, Cheng Y, Fitzgerald GA (2005) Cardiovascular hazard and non-steroidal anti-inflammatory drugs. Curr Opin Pharmacol 5: 204-210
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 204-210
    • Wang, D.1    Wang, M.2    Cheng, Y.3    Fitzgerald, G.A.4
  • 61
    • 47249134658 scopus 로고    scopus 로고
    • Combination regimen with statins and NSAIDs: A promising strategy for cancer chemoprevention
    • Xiao H, Yang CS (2008) Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. Int J Cancer 123: 983-990
    • (2008) Int J Cancer , vol.123 , pp. 983-990
    • Xiao, H.1    Yang, C.S.2
  • 63
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • Zimmermann GR, Lehar J, Keith CT (2007) Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12: 34-42
    • (2007) Drug Discov Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3


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