-
1
-
-
79952918847
-
Novel 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors: A patent review
-
J.A. Pfefferkorn Novel 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors: a patent review Expert Opin Ther Pat 21 2011 187 203
-
(2011)
Expert Opin Ther Pat
, vol.21
, pp. 187-203
-
-
Pfefferkorn, J.A.1
-
2
-
-
0035960630
-
Global burden of cardiovascular diseases. Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization
-
S. Yusuf, S. Reddy, S. Ounpuu, and S. Anand Global burden of cardiovascular diseases. Part I. General considerations, the epidemiologic transition, risk factors, and impact of urbanization Circulation 104 2001 2746 2753 (Pubitemid 33108145)
-
(2001)
Circulation
, vol.104
, Issue.22
, pp. 2746-2753
-
-
Yusuf, S.1
Reddy, S.2
Ounpuu, S.3
Anand, S.4
-
3
-
-
79751531393
-
Heart disease and stroke statistics - 2011 update: A report from the american heart association
-
V.L. Roger, A.S. Go, D.M. Lloyd-Jones, R.J. Adams, J.D. Berry, and T.M. Brown Heart disease and stroke statistics - 2011 update: a report from the american heart association Circulation 123 2011 e18 e209
-
(2011)
Circulation
, vol.123
-
-
Roger, V.L.1
Go, A.S.2
Lloyd-Jones, D.M.3
Adams, R.J.4
Berry, J.D.5
Brown, T.M.6
-
5
-
-
79955460186
-
Safety review of combination drugs for hyperlipidemia
-
M. Farnier Safety review of combination drugs for hyperlipidemia Expert Opin Drug Saf 10 2011 363 371
-
(2011)
Expert Opin Drug Saf
, vol.10
, pp. 363-371
-
-
Farnier, M.1
-
6
-
-
79955481506
-
Pharmacological strategies for lowering LDL cholesterol: Statins and beyond
-
A. Brautbar, and C.M. Ballantyne Pharmacological strategies for lowering LDL cholesterol: statins and beyond Nat Rev Cardiol 8 2011 253 265
-
(2011)
Nat Rev Cardiol
, vol.8
, pp. 253-265
-
-
Brautbar, A.1
Ballantyne, C.M.2
-
7
-
-
53549101905
-
A gift from nature: The birth of the statins
-
A. Endo A gift from nature: the birth of the statins Nat Med 14 2008 1050 1052
-
(2008)
Nat Med
, vol.14
, pp. 1050-1052
-
-
Endo, A.1
-
8
-
-
0029050796
-
Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The regression growth evaluation statin study (REGRESS)
-
J.W. Jukema, A.V. Bruschke, A.J. van Boven, J.H. Reiber, E.T. Bal, and A.H. Zwinderman Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The regression growth evaluation statin study (REGRESS) Circulation 91 1995 2528 2540
-
(1995)
Circulation
, vol.91
, pp. 2528-2540
-
-
Jukema, J.W.1
Bruschke, A.V.2
Van Boven, A.J.3
Reiber, J.H.4
Bal, E.T.5
Zwinderman, A.H.6
-
10
-
-
40749104579
-
Pleiotropic effects: Should statins be considered an essential component in the treatment of dyslipidemia?
-
DOI 10.1007/s11883-008-0008-0
-
M.E. Mays, and C.A. Dujovne Pleiotropic effects: should statins be considered an essential component in the treatment of dyslipidemia? Curr Atheroscler Rep 10 2008 45 52 (Pubitemid 351385599)
-
(2008)
Current Atherosclerosis Reports
, vol.10
, Issue.1
, pp. 45-52
-
-
Mays, M.E.1
Dujovne, C.A.2
-
11
-
-
35248885161
-
Statin-associated adverse effects beyond muscle and liver toxicity
-
DOI 10.1016/j.atherosclerosis.2006.10.001, PII S0021915006006034
-
D.N. Kiortsis, T.D. Filippatos, D.P. Mikhailidis, M.S. Elisaf, and E.N. Liberopoulos Statin-associated adverse effects beyond muscle and liver toxicity Atherosclerosis 195 2007 7 16 (Pubitemid 47561937)
-
(2007)
Atherosclerosis
, vol.195
, Issue.1
, pp. 7-16
-
-
Kiortsis, D.N.1
Filippatos, T.D.2
Mikhailidis, D.P.3
Elisaf, M.S.4
Liberopoulos, E.N.5
-
12
-
-
34447307653
-
The broad spectrum of statin myopathy: From myalgia to rhabdomyolysis
-
DOI 10.1097/MOL.0b013e32825a6773, PII 0004143320070800000005
-
C.R. Harper, and T.A. Jacobson The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis Curr Opin Lipidol 18 2007 401 408 (Pubitemid 47051918)
-
(2007)
Current Opinion in Lipidology
, vol.18
, Issue.4
, pp. 401-408
-
-
Harper, C.R.1
Jacobson, T.A.2
-
13
-
-
1542780828
-
Niacin, lipids, and heart disease
-
S. Malik, and M.L. Kashyap Niacin, lipids, and heart disease Curr Cardiol Rep 5 2003 470 476 (Pubitemid 38906894)
-
(2003)
Current Cardiology Reports
, vol.5
, Issue.6
, pp. 470-476
-
-
Malik, S.1
Kashyap, M.L.2
-
14
-
-
0000242585
-
The effect of nicotinic acid on the plasma free fatty acid; Demonstration of a metabolic type of sympathicolysis
-
L.A. Carlson, and L. Oro The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis Acta Med Scand 172 1962 641 645
-
(1962)
Acta Med Scand
, vol.172
, pp. 641-645
-
-
Carlson, L.A.1
Oro, L.2
-
15
-
-
68949215867
-
The mechanism and mitigation of niacin-induced flushing
-
V.S. Kamanna, S.H. Ganji, and M.L. Kashyap The mechanism and mitigation of niacin-induced flushing Int J Clin Pract 63 2009 1369 1377
-
(2009)
Int J Clin Pract
, vol.63
, pp. 1369-1377
-
-
Kamanna, V.S.1
Ganji, S.H.2
Kashyap, M.L.3
-
16
-
-
74049112916
-
Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemia
-
K.G. Parhofer Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemia Vasc Health Risk Manag 5 2009 901 908
-
(2009)
Vasc Health Risk Manag
, vol.5
, pp. 901-908
-
-
Parhofer, K.G.1
-
17
-
-
80053906798
-
Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters
-
H. Vosper Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters Clin Med Insights Cardiol 5 2011 85 101
-
(2011)
Clin Med Insights Cardiol
, vol.5
, pp. 85-101
-
-
Vosper, H.1
-
19
-
-
33645735636
-
Effects of colesevelam hydrochloride on low-density lipoprotein cholesterol and high-sensitivity c-reactive protein when added to statins in patients with hypercholesterolemia
-
H.E. Bays, M. Davidson, M.R. Jones, and S.L. Abby Effects of colesevelam hydrochloride on low-density lipoprotein cholesterol and high-sensitivity c-reactive protein when added to statins in patients with hypercholesterolemia Am J Cardiol 97 2006 1198 1205
-
(2006)
Am J Cardiol
, vol.97
, pp. 1198-1205
-
-
Bays, H.E.1
Davidson, M.2
Jones, M.R.3
Abby, S.L.4
-
20
-
-
0026032543
-
Bile acid sequestrants: Mechanisms of action on bile acid and cholesterol metabolism
-
K. Einarsson, S. Ericsson, S. Ewerth, E. Reihner, M. Rudling, and D. Stahlberg Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism Eur J Clin Pharmacol 40 Suppl 1 1991 S53 S58
-
(1991)
Eur J Clin Pharmacol
, vol.40
, Issue.SUPPL. 1
-
-
Einarsson, K.1
Ericsson, S.2
Ewerth, S.3
Reihner, E.4
Rudling, M.5
Stahlberg, D.6
-
21
-
-
10744221008
-
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
-
DOI 10.1126/science.1093131
-
S.W. Altmann, H.R. Davis, L.J. Zhu, X.R. Yao, L.M. Hoos, and G. Tetzloff Niemann-pick c1 like 1 protein is critical for intestinal cholesterol absorption Science 303 2004 1201 1204 (Pubitemid 38233587)
-
(2004)
Science
, vol.303
, Issue.5661
, pp. 1201-1204
-
-
Altmann, S.W.1
Davis Jr., H.R.2
Zhu, L.-J.3
Yao, X.4
Hoos, L.M.5
Tetzloff, G.6
Iyer, S.P.N.7
Maguire, M.8
Golovko, A.9
Zeng, M.10
Wang, L.11
Murgolo, N.12
Graziano, M.P.13
-
22
-
-
4043124013
-
Niemann-Pick C1 like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
-
DOI 10.1074/jbc.M405817200
-
H.R. Davis, L.J. Zhu, L.M. Hoos, G. Tetzloff, M. Maguire, and J.J. Liu Niemann-pick c1 like 1 (npc1l1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis J Biol Chem 279 2004 33586 33592 (Pubitemid 39063007)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.32
, pp. 33586-33592
-
-
Davis Jr., H.R.1
Zhu, L.-J.2
Hoos, L.M.3
Tetzloff, G.4
Maguire, M.5
Liu, J.6
Yao, X.7
Iyer, S.P.N.8
Lam, M.-H.9
Lund, E.G.10
Detmers, P.A.11
Graziano, M.P.12
Altmann, S.W.13
-
23
-
-
0037395141
-
Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia
-
DOI 10.1016/S0195-668X(02)00807-2
-
R.H. Knopp, H. Gitter, T. Truitt, H. Bays, C.V. Manion, and L.J. Lipka Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia Eur Heart J 24 2003 729 741 (Pubitemid 36458985)
-
(2003)
European Heart Journal
, vol.24
, Issue.8
, pp. 729-741
-
-
Knopp, R.H.1
Gitter, H.2
Truitt, T.3
Bays, H.4
Manion, C.V.5
Lipka, L.J.6
LeBeaut, A.P.7
Suresh, R.8
Yang, B.9
Veltri, E.P.10
-
24
-
-
0037111924
-
Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
-
DOI 10.1016/S0002-9149(02)02798-4, PII S0002914902027984
-
C.A. Dujovne, M.P. Ettinger, J.F. McNeer, L.J. Lipka, A.P. LeBeaut, and R. Suresh Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia Am J Cardiol 90 2002 1092 1097 (Pubitemid 35335597)
-
(2002)
American Journal of Cardiology
, vol.90
, Issue.10
, pp. 1092-1097
-
-
Dujovne, C.A.1
Ettinger, M.P.2
McNeer, J.F.3
Lipka, L.J.4
LeBeaut, A.P.5
Suresh, R.6
Yang, B.O.7
Veltri, E.P.8
-
25
-
-
41649107358
-
Simvastatin with or without ezetimibe in familial hypercholesterolemia
-
DOI 10.1056/NEJMoa0800742
-
J.J.P. Kastelein, F. Akdim, E.S.G. Stroes, A.H. Zwinderman, M.L. Bots, and A.F.H. Stalenhoef Simvastatin with or without ezetimibe in familial hypercholesterolemia N Engl J Med 358 2008 1431 1443 (Pubitemid 351482735)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.14
, pp. 1431-1443
-
-
Kastelein, J.J.P.1
Akdim, F.2
Stroes, E.S.G.3
Zwinderman, A.H.4
Bots, M.L.5
Stalenhoef, A.F.H.6
Visseren, F.L.J.7
Sijbrands, E.J.G.8
Trip, M.D.9
Stein, E.A.10
Gaudet, D.11
Duivenvoorden, R.12
Veltri, E.P.13
Marais, A.D.14
De Groot, E.15
-
26
-
-
11844296800
-
Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials
-
DOI 10.1016/j.jacc.2004.10.031, PII S0735109704020625
-
R.S. Birjmohun, B.A. Hutten, J.J. Kastelein, and E.S. Stroes Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials J Am Coll Cardiol 45 2005 185 197 (Pubitemid 40094724)
-
(2005)
Journal of the American College of Cardiology
, vol.45
, Issue.2
, pp. 185-197
-
-
Birjmohun, R.S.1
Hutten, B.A.2
Kastelein, J.J.P.3
Stroes, E.S.G.4
-
27
-
-
0024334111
-
Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review
-
W.S. Harris Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review J Lipid Res 30 1989 785 807 (Pubitemid 19167302)
-
(1989)
Journal of Lipid Research
, vol.30
, Issue.6
, pp. 785-807
-
-
Harris, W.S.1
-
28
-
-
0024215029
-
Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase
-
A.C. Rustan, J.O. Nossen, E.N. Christiansen, and C.A. Drevon Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme a:1,2-diacylglycerol acyltransferase J Lipid Res 29 1988 1417 1426 (Pubitemid 19013036)
-
(1988)
Journal of Lipid Research
, vol.29
, Issue.11
, pp. 1417-1426
-
-
Rustan, A.C.1
Nossen, J.O.2
Christiansen, E.N.3
Drevon, C.A.4
-
29
-
-
4644289020
-
Polyunsaturated fatty acid regulation of gene expression
-
DOI 10.1301/nr.2004.sept.333-339
-
H. Sampath, and J.M. Ntambi Polyunsaturated fatty acid regulation of gene expression Nutr Rev 62 2004 333 339 (Pubitemid 39299134)
-
(2004)
Nutrition Reviews
, vol.62
, Issue.9
, pp. 333-339
-
-
Sampath, H.1
Ntambi, J.M.2
-
30
-
-
0031425356
-
Safety and efficacy of Omacor in severe hypertriglyceridemia
-
W.S. Harris, H.N. Ginsberg, N. Arunakul, N.S. Shachter, S.L. Windsor, and M. Adams Safety and efficacy of omacor in severe hypertriglyceridemia J Cardiovasc Risk 4 1997 385 391 (Pubitemid 28078682)
-
(1997)
Journal of Cardiovascular Risk
, vol.4
, Issue.5-6
, pp. 385-391
-
-
Harris, W.S.1
Ginsberg, H.N.2
Arunakul, N.3
Shachter, N.S.4
Windsor, S.L.5
Adams, M.6
Berglund, L.7
Osmundsen, K.8
-
31
-
-
77952925860
-
Molecular pathways and agents for lowering LDL-cholesterol in addition to statins
-
P. Costet Molecular pathways and agents for lowering LDL-cholesterol in addition to statins Pharmacol Ther 126 2010 263 278
-
(2010)
Pharmacol Ther
, vol.126
, pp. 263-278
-
-
Costet, P.1
-
32
-
-
58149202133
-
Squalene synthase: A critical enzyme in the cholesterol biosynthesis pathway
-
R. Do, R.S. Kiss, D. Gaudet, and J.C. Engert Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway Clin Genet 75 2009 19 29
-
(2009)
Clin Genet
, vol.75
, pp. 19-29
-
-
Do, R.1
Kiss, R.S.2
Gaudet, D.3
Engert, J.C.4
-
33
-
-
0037622980
-
Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro
-
DOI 10.1038/sj.bjp.0705332
-
T. Nishimoto, Y. Amano, R. Tozawa, E. Ishikawa, Y. Imura, and H. Yukimasa Lipid-lowering properties of tak-475, a squalene synthase inhibitor, in vivo and in vitro Br J Pharmacol 139 2003 911 918 (Pubitemid 36877390)
-
(2003)
British Journal of Pharmacology
, vol.139
, Issue.5
, pp. 911-918
-
-
Nishimoto, T.1
Amano, Y.2
Tozawa, R.3
Ishikawa, E.4
Imura, Y.5
Yukimasa, H.6
Sugiyama, Y.7
-
34
-
-
79955762929
-
Lapaquistat acetate: Development of a squalene synthase inhibitor for the treatment of hypercholesterolemia
-
E.A. Stein, H. Bays, D. O'Brien, J. Pedicano, E. Piper, and A. Spezzi Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia Circulation 123 2011 1974 1985
-
(2011)
Circulation
, vol.123
, pp. 1974-1985
-
-
Stein, E.A.1
Bays, H.2
O'Brien, D.3
Pedicano, J.4
Piper, E.5
Spezzi, A.6
-
35
-
-
79953288885
-
Identification and optimization of tetrahydro-2h-3-benzazepin-2-ones as squalene synthase inhibitors
-
N. Griebenow, T. Flessner, A. Buchmueller, M. Raabe, H. Bischoff, and P. Kolkhof Identification and optimization of tetrahydro-2h-3-benzazepin-2-ones as squalene synthase inhibitors Bioorg Med Chem Lett 21 2011 2554 2558
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 2554-2558
-
-
Griebenow, N.1
Flessner, T.2
Buchmueller, A.3
Raabe, M.4
Bischoff, H.5
Kolkhof, P.6
-
36
-
-
80052865213
-
Two squalene synthase inhibitors, e5700 and er-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin b
-
K. Ishida, G. Visbal, J.C.F. Rodrigues, J.A. Urbina, W. De Souza, and S. Rozental Two squalene synthase inhibitors, e5700 and er-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin b J Infect Chemother 17 2011 563 570
-
(2011)
J Infect Chemother
, vol.17
, pp. 563-570
-
-
Ishida, K.1
Visbal, G.2
Rodrigues, J.C.F.3
Urbina, J.A.4
De Souza, W.5
Rozental, S.6
-
37
-
-
79957811546
-
Identification of 4h,6h-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors
-
N. Griebenow, A. Buchmueller, P. Kolkhof, J. Schamberger, and H. Bischoff Identification of 4h,6h-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors Bioorg Med Chem Lett 21 2011 3648 3653
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 3648-3653
-
-
Griebenow, N.1
Buchmueller, A.2
Kolkhof, P.3
Schamberger, J.4
Bischoff, H.5
-
38
-
-
84860389049
-
Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors
-
M. Ichikawa, A. Yokomizo, M. Itoh, N. Haginoya, K. Sugita, and H. Usui Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors Bioorg Med Chem 19 2011 5207 5224
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 5207-5224
-
-
Ichikawa, M.1
Yokomizo, A.2
Itoh, M.3
Haginoya, N.4
Sugita, K.5
Usui, H.6
-
39
-
-
79952442829
-
Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
-
M. Ichikawa, A. Yokomizo, M. Itoh, K. Sugita, H. Usui, and H. Shimizu Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors Bioorg Med Chem 19 2011 1930 1949
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 1930-1949
-
-
Ichikawa, M.1
Yokomizo, A.2
Itoh, M.3
Sugita, K.4
Usui, H.5
Shimizu, H.6
-
41
-
-
0030943621
-
Acyl-coenzyme a:cholesterol acyltransferase
-
T.Y. Chang, C.C. Chang, and D. Cheng Acyl-coenzyme a:cholesterol acyltransferase Annu Rev Biochem 66 1997 613 638
-
(1997)
Annu Rev Biochem
, vol.66
, pp. 613-638
-
-
Chang, T.Y.1
Chang, C.C.2
Cheng, D.3
-
42
-
-
49449106497
-
Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins
-
K. El Harchaoui, F. Akdim, E.S. Stroes, M.D. Trip, and J.J. Kastelein Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins Am J Cardiovasc Drugs 8 2008 233 242
-
(2008)
Am J Cardiovasc Drugs
, vol.8
, pp. 233-242
-
-
El Harchaoui, K.1
Akdim, F.2
Stroes, E.S.3
Trip, M.D.4
Kastelein, J.J.5
-
43
-
-
62649118779
-
Acat inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: The captivate randomized trial
-
M.C. Meuwese, E. de Groot, R. Duivenvoorden, M.D. Trip, L. Ose, and F.J. Maritz Acat inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the captivate randomized trial J Am Med Assoc 301 2009 1131 1139
-
(2009)
J Am Med Assoc
, vol.301
, pp. 1131-1139
-
-
Meuwese, M.C.1
De Groot, E.2
Duivenvoorden, R.3
Trip, M.D.4
Ose, L.5
Maritz, F.J.6
-
44
-
-
77955380680
-
Novel acyl-CoA:cholesterol acyltransferase inhibitor: Indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio
-
K. Takahashi, M. Ohta, Y. Shoji, M. Kasai, K. Kunishiro, and T. Miike Novel acyl-CoA:cholesterol acyltransferase inhibitor: indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio Chem Pharm Bull (Tokyo) 58 2010 1057 1065
-
(2010)
Chem Pharm Bull (Tokyo)
, vol.58
, pp. 1057-1065
-
-
Takahashi, K.1
Ohta, M.2
Shoji, Y.3
Kasai, M.4
Kunishiro, K.5
Miike, T.6
-
45
-
-
77955363537
-
Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA:cholesterol acyltransferase and lipid peroxidation
-
M. Ohta, K. Takahashi, M. Kasai, Y. Shoji, K. Kunishiro, and T. Miike Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA:cholesterol acyltransferase and lipid peroxidation Chem Pharm Bull (Tokyo) 58 2010 1066 1076
-
(2010)
Chem Pharm Bull (Tokyo)
, vol.58
, pp. 1066-1076
-
-
Ohta, M.1
Takahashi, K.2
Kasai, M.3
Shoji, Y.4
Kunishiro, K.5
Miike, T.6
-
46
-
-
80053425950
-
Discovery of a potent and orally available acyl-CoA:cholesterol acyltransferase inhibitor as an anti-atherosclerotic agent: (4-phenylcoumarin) acetanilide derivatives
-
M. Ogino, S. Fukui, Y. Nakada, R. Tokunoh, S. Itokawa, and Y. Kakoi Discovery of a potent and orally available acyl-CoA:cholesterol acyltransferase inhibitor as an anti-atherosclerotic agent: (4-phenylcoumarin) acetanilide derivatives Chem Pharm Bull (Tokyo) 59 2011 1268 1273
-
(2011)
Chem Pharm Bull (Tokyo)
, vol.59
, pp. 1268-1273
-
-
Ogino, M.1
Fukui, S.2
Nakada, Y.3
Tokunoh, R.4
Itokawa, S.5
Kakoi, Y.6
-
47
-
-
77958459353
-
A selective acat-1 inhibitor, k-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein e-knockout mice
-
Y. Yoshinaka, H. Shibata, H. Kobayashi, H. Kuriyama, K. Shibuya, and S. Tanabe A selective acat-1 inhibitor, k-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein e-knockout mice Atherosclerosis 213 2010 85 91
-
(2010)
Atherosclerosis
, vol.213
, pp. 85-91
-
-
Yoshinaka, Y.1
Shibata, H.2
Kobayashi, H.3
Kuriyama, H.4
Shibuya, K.5
Tanabe, S.6
-
48
-
-
79955602758
-
Pyripyropene a, an acyl-coenzyme a:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia
-
T. Ohshiro, D. Matsuda, K. Sakai, C. Degirolamo, H. Yagyu, and L.L. Rudel Pyripyropene a, an acyl-coenzyme a:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia Arterioscler Thromb Vasc Biol 31 2011 1108 1115
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 1108-1115
-
-
Ohshiro, T.1
Matsuda, D.2
Sakai, K.3
Degirolamo, C.4
Yagyu, H.5
Rudel, L.L.6
-
49
-
-
79551517633
-
Therapies targeting exogenous cholesterol uptake: New insights and controversies
-
M.H. Davidson Therapies targeting exogenous cholesterol uptake: new insights and controversies Curr Atheroscler Rep 13 2011 95 100
-
(2011)
Curr Atheroscler Rep
, vol.13
, pp. 95-100
-
-
Davidson, M.H.1
-
50
-
-
0034655917
-
Evidence for a niemann-pick C (NPC) gene family: Identification and characterization of NPC1L1
-
DOI 10.1006/geno.2000.6151
-
J.P. Davies, B. Levy, and Y.A. Ioannou Evidence for a niemann-pick c (npc) gene family: identification and characterization of npc1l1 Genomics 65 2000 137 145 (Pubitemid 30314421)
-
(2000)
Genomics
, vol.65
, Issue.2
, pp. 137-145
-
-
Davies, J.P.1
Levy, B.2
Ioannou, Y.A.3
-
51
-
-
16844376244
-
Inactivation of npc1l1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia
-
J.P. Davies, C. Scott, K. Oishi, A. Liapis, and Y.A. Ioannou Inactivation of npc1l1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia J Biol Chem 280 2005 12710 12720
-
(2005)
J Biol Chem
, vol.280
, pp. 12710-12720
-
-
Davies, J.P.1
Scott, C.2
Oishi, K.3
Liapis, A.4
Ioannou, Y.A.5
-
52
-
-
34547857877
-
Inhibition of niemann-pick c1 like 1 (npc1l1) to reduce intestinal cholesterol absorption and treat hyperlipidemia
-
H.R. Davis, E.P. Veltri, and 1. Zetia Inhibition of niemann-pick c1 like 1 (npc1l1) to reduce intestinal cholesterol absorption and treat hyperlipidemia J Atheroscler Thromb 14 2007 99 108
-
(2007)
J Atheroscler Thromb
, vol.14
, pp. 99-108
-
-
Davis, H.R.1
Veltri, E.P.2
Zetia, I.3
-
53
-
-
78149281356
-
Spiroimidazolidinone npc1l1 inhibitors. Part 2. Structure-activity studies and in vivo efficacy
-
K.L. Howell, R.J. Devita, M. Garcia-Calvo, R.D. Meurer, J. Lisnock, and H.G. Bull Spiroimidazolidinone npc1l1 inhibitors. Part 2. Structure-activity studies and in vivo efficacy Bioorg Med Chem Lett 20 2010 6929 6932
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 6929-6932
-
-
Howell, K.L.1
Devita, R.J.2
Garcia-Calvo, M.3
Meurer, R.D.4
Lisnock, J.5
Bull, H.G.6
-
54
-
-
84863422027
-
Discovery of a novel and potent cholesterol absorption inhibitor (cai) as promising orally active lipid lowering drug
-
M. Kanou, Y. Nisiwaki, A. Nakano, Y. Sugimoto, Y. Yamanaka, and S. Kondo Discovery of a novel and potent cholesterol absorption inhibitor (cai) as promising orally active lipid lowering drug Atheroscler Suppl 2009 10
-
(2009)
Atheroscler Suppl
, pp. 10
-
-
Kanou, M.1
Nisiwaki, Y.2
Nakano, A.3
Sugimoto, Y.4
Yamanaka, Y.5
Kondo, S.6
-
55
-
-
84863409157
-
Curcumin down-regulates niemann-pick c1-like 1 expression in intestinal epithelial cells
-
P. Kumar, A. Singla, O. Hedroug, H. Liu, F. Annaba, and S. Saksena Curcumin down-regulates niemann-pick c1-like 1 expression in intestinal epithelial cells Gastroenterology 136 2009 A567 A568
-
(2009)
Gastroenterology
, vol.136
-
-
Kumar, P.1
Singla, A.2
Hedroug, O.3
Liu, H.4
Annaba, F.5
Saksena, S.6
-
56
-
-
77953699732
-
Npc1l1 and cholesterol transport
-
J.L. Betters, and L. Yu Npc1l1 and cholesterol transport FEBS Lett 584 2010 2740 2747
-
(2010)
FEBS Lett
, vol.584
, pp. 2740-2747
-
-
Betters, J.L.1
Yu, L.2
-
57
-
-
79958005310
-
New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: Frontiers for new pharmaceutical therapies to lower cardiovascular disease risk
-
S. Warnakula, J. Hsieh, K. Adeli, M.M. Hussain, P. Tso, and S.D. Proctor New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk Can J Cardiol 27 2011 183 191
-
(2011)
Can J Cardiol
, vol.27
, pp. 183-191
-
-
Warnakula, S.1
Hsieh, J.2
Adeli, K.3
Hussain, M.M.4
Tso, P.5
Proctor, S.D.6
-
58
-
-
0022549920
-
A receptor-mediated pathway for cholesterol homeostasis
-
M.S. Brown, and J.L. Goldstein A receptor-mediated pathway for cholesterol homeostasis Science 232 1986 34 47 (Pubitemid 16037973)
-
(1986)
Science
, vol.232
, Issue.4746
, pp. 34-47
-
-
Brown, M.S.1
Goldstein, J.L.2
-
60
-
-
0035021435
-
Intestinal bile acid transport: Biology, physiology, and pathophysiology
-
DOI 10.1097/00005176-200104000-00002
-
B.L. Shneider Intestinal bile acid transport: biology, physiology, and pathophysiology J Pediatr Gastroenterol Nutr 32 2001 407 417 (Pubitemid 32488295)
-
(2001)
Journal of Pediatric Gastroenterology and Nutrition
, vol.32
, Issue.4
, pp. 407-417
-
-
Shneider, B.L.1
-
61
-
-
0037204542
-
Modeling of active transport systems
-
DOI 10.1016/S0169-409X(02)00007-8, PII S0169409X02000078
-
E.Y. Zhang, M.A. Phelps, C. Cheng, S. Ekins, and P.W. Swaan Modeling of active transport systems Adv Drug Deliv Rev 54 2002 329 354 (Pubitemid 34260957)
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.3
, pp. 329-354
-
-
Zhang, E.Y.1
Phelps, M.A.2
Cheng, C.3
Ekins, S.4
Swaan, P.W.5
-
62
-
-
33646016599
-
Bile acid reabsorption inhibitors (BARI): Novel hypolipidemic drugs
-
W. Kramer, and H. Glombik Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugs Curr Med Chem 13 2006 997 1016
-
(2006)
Curr Med Chem
, vol.13
, pp. 997-1016
-
-
Kramer, W.1
Glombik, H.2
-
64
-
-
0028323006
-
Specific inhibitors of ileal bile acid transport [1]
-
G. Wess, W. Kramer, A. Enhsen, H. Glombik, K.H. Baringhaus, and G. Boger Specific inhibitors of ileal bile acid transport J Med Chem 37 1994 873 875 (Pubitemid 24140854)
-
(1994)
Journal of Medicinal Chemistry
, vol.37
, Issue.7
, pp. 873-875
-
-
Wess, G.1
Kramer, W.2
Enhsen, A.3
Glombik, H.4
Baringhaus, K.-H.5
Boger, G.6
Urmann, M.7
Bock, K.8
Kleine, H.9
Neckermann, G.10
Hoffmann, A.11
Pittius, C.12
Falk, E.13
Fehlhaber, H.-W.14
Kogler, H.15
Friedrich, M.16
-
65
-
-
0141545117
-
A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines
-
DOI 10.1016/j.bmcl.2003.08.004
-
M.B. Tollefson, S.A. Kolodziej, T.R. Fletcher, W.F. Vernier, J.A. Beaudry, and B.T. Keller A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 1,2-benzothiazepines Bioorg Med Chem Lett 13 2003 3727 3730 (Pubitemid 37206496)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.21
, pp. 3727-3730
-
-
Tollefson, M.B.1
Kolodziej, S.A.2
Fletcher, T.R.3
Vernier, W.F.4
Beaudry, J.A.5
Keller, B.T.6
Reitz, D.B.7
-
66
-
-
24944565175
-
Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (part 1)
-
DOI 10.1021/jm040215+
-
S.J. Tremont, L.F. Lee, H.C. Huang, B.T. Keller, S.C. Banerjee, and S.R. Both Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 1) J Med Chem 48 2005 5837 5852 (Pubitemid 41319713)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.18
, pp. 5837-5852
-
-
Tremont, S.J.1
Lee, L.F.2
Huang, H.-C.3
Keller, B.T.4
Banerjee, S.C.5
Both, S.R.6
Carpenter, A.J.7
Wang, C.-C.8
Garland, D.J.9
Huang, W.10
Jones, C.11
Koeller, K.J.12
Kolodziej, S.A.13
Li, J.14
Manning, R.E.15
Mahoney, M.W.16
Miller, R.E.17
Mischke, D.A.18
Rath, N.P.19
Fletcher, T.20
Reinhard, E.J.21
Tollefson, M.B.22
Vernier, W.F.23
Wagner, G.M.24
Rapp, S.R.25
Beaudry, J.26
Glenn, K.27
Regina, K.28
Schuh, J.R.29
Smith, M.E.30
Trivedi, J.S.31
Reitz, D.B.32
more..
-
67
-
-
0029010724
-
Effects of 2164u90 on ileal bile acid absorption and serum cholesterol in rats and mice
-
M.C. Lewis, L.E. Brieaddy, and C. Root Effects of 2164u90 on ileal bile acid absorption and serum cholesterol in rats and mice J Lipid Res 36 1995 1098 1105
-
(1995)
J Lipid Res
, vol.36
, pp. 1098-1105
-
-
Lewis, M.C.1
Brieaddy, L.E.2
Root, C.3
-
69
-
-
0026470990
-
Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
-
J.R. Wetterau, L.P. Aggerbeck, M.E. Bouma, C. Eisenberg, A. Munck, and M. Hermier Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia Science 258 1992 999
-
(1992)
Science
, vol.258
, pp. 999
-
-
Wetterau, J.R.1
Aggerbeck, L.P.2
Bouma, M.E.3
Eisenberg, C.4
Munck, A.5
Hermier, M.6
-
70
-
-
43249096797
-
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism
-
DOI 10.1097/MOL.0b013e3282feea85, PII 0004143320080600000010
-
M.M. Hussain, P. Rava, X. Pan, K. Dai, S.K. Dougan, and J. Iqbal Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism Curr Opin Lipidol 19 2008 277 284 (Pubitemid 351653566)
-
(2008)
Current Opinion in Lipidology
, vol.19
, Issue.3
, pp. 277-284
-
-
Hussain, M.M.1
Rava, P.2
Pan, X.3
Dai, K.4
Dougan, S.K.5
Iqbal, J.6
Lazare, F.7
Khatun, I.8
-
71
-
-
33846151732
-
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
-
DOI 10.1056/NEJMoa061189
-
M. Cuchel, L.T. Bloedon, P.O. Szapary, D.M. Kolansky, M.L. Wolfe, and A. Sarkis Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia N Engl J Med 356 2007 148 156 (Pubitemid 46089675)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 148-156
-
-
Cuchel, M.1
Bloedon, L.T.2
Szapary, P.O.3
Kolansky, D.M.4
Wolfe, M.L.5
Sarkis, A.6
Millar, J.S.7
Ikewaki, K.8
Siegelman, E.S.9
Gregg, R.E.10
Rader, D.J.11
-
72
-
-
48349088178
-
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
-
F.F. Samaha, J. McKenney, L.T. Bloedon, W.J. Sasiela, and D.J. Rader Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia Nat Clin Pract Cardiovasc Med 5 2008 497 505
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 497-505
-
-
Samaha, F.F.1
McKenney, J.2
Bloedon, L.T.3
Sasiela, W.J.4
Rader, D.J.5
-
73
-
-
48349085741
-
Microsomal triglyceride transfer protein inhibition: Friend or foe?
-
T.R. Joy, and R.A. Hegele Microsomal triglyceride transfer protein inhibition: friend or foe? Nat Clin Pract Cardiovasc Med 5 2008 506 508
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 506-508
-
-
Joy, T.R.1
Hegele, R.A.2
-
74
-
-
79956333142
-
Jtt-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in zucker diabetic fatty rats
-
T. Hata, Y. Mera, T. Kawai, Y. Ishii, Y. Kuroki, and K. Kakimoto Jtt-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in zucker diabetic fatty rats Diabetes Obes Metab 13 2011 629 638
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 629-638
-
-
Hata, T.1
Mera, Y.2
Kawai, T.3
Ishii, Y.4
Kuroki, Y.5
Kakimoto, K.6
-
75
-
-
26844580001
-
Jtt-130, a microsomal triglyceride transfer protein (mtp) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
-
D. Aggarwal, K.L. West, T.L. Zern, S. Shrestha, M. Vergara-Jimenez, and M.L. Fernandez Jtt-130, a microsomal triglyceride transfer protein (mtp) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs BMC Cardiovasc Disord 2005 5
-
(2005)
BMC Cardiovasc Disord
, pp. 5
-
-
Aggarwal, D.1
West, K.L.2
Zern, T.L.3
Shrestha, S.4
Vergara-Jimenez, M.5
Fernandez, M.L.6
-
76
-
-
84863414967
-
Clinical investigations into the role of mtp in chylomicron formation using slx-4090, an enterocyte-specific inhibitor
-
W. Tong, E. Paradise, O. Schueller, J. Ferkany, and P. Sweetnam Clinical investigations into the role of mtp in chylomicron formation using slx-4090, an enterocyte-specific inhibitor Atheroscler Suppl 2009 10
-
(2009)
Atheroscler Suppl
, pp. 10
-
-
Tong, W.1
Paradise, E.2
Schueller, O.3
Ferkany, J.4
Sweetnam, P.5
-
77
-
-
79956202758
-
A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, slx-4090: Biochemical, pharmacodynamic, pharmacokinetic, and safety profile
-
E. Kim, S. Campbell, O. Schueller, E. Wong, B. Cole, and J. Kuo A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, slx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile J Pharmacol Exp Ther 337 2011 775 785
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 775-785
-
-
Kim, E.1
Campbell, S.2
Schueller, O.3
Wong, E.4
Cole, B.5
Kuo, J.6
-
78
-
-
33847623317
-
In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2- carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity
-
DOI 10.1016/j.bmcl.2007.01.018, PII S0960894X07000662
-
J. Li, B.S. Bronk, J.P. Dirlam, A.E. Blize, P. Bertinato, and B.H. Jaynes In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2- carbonyl)-amino]-1h-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent mtp inhibitor for obesity Bioorg Med Chem Lett 17 2007 1996 1999 (Pubitemid 46367656)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.7
, pp. 1996-1999
-
-
Li, J.1
Bronk, B.S.2
Dirlam, J.P.3
Blize, A.E.4
Bertinato, P.5
Jaynes, B.H.6
Hickman, A.7
Miskell, C.8
Pillai, U.A.9
Tibbitts, J.S.10
Haven, M.L.11
Kolosko, N.L.12
Barry, C.J.13
Manion, T.B.14
-
79
-
-
79959895309
-
Discovery of microsomal triglyceride transfer protein (mtp) inhibitors with potential for decreased active metabolite load compared to dirlotapide
-
R.P. Robinson, J.A. Bartlett, P. Bertinato, A.J. Bessire, J. Cosgrove, and P.M. Foley Discovery of microsomal triglyceride transfer protein (mtp) inhibitors with potential for decreased active metabolite load compared to dirlotapide Bioorg Med Chem Lett 21 2011 4150 4154
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 4150-4154
-
-
Robinson, R.P.1
Bartlett, J.A.2
Bertinato, P.3
Bessire, A.J.4
Cosgrove, J.5
Foley, P.M.6
-
80
-
-
33847338002
-
Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100
-
DOI 10.1124/dmd.106.012401
-
R.Z. Yu, T.W. Kim, A. Hong, T.A. Watanabe, H.J. Gaus, and R.S. Geary Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, isis 301012, targeting human apolipoprotein b-100 Drug Metab Dispos 35 2007 460 468 (Pubitemid 46333910)
-
(2007)
Drug Metabolism and Disposition
, vol.35
, Issue.3
, pp. 460-468
-
-
Yu, R.Z.1
Kim, T.-W.2
Hong, A.3
Watanabe, T.A.4
Gaus, H.J.5
Geary, R.S.6
-
81
-
-
84978763222
-
Mipomersen, a first-in-class apolipoprotein b synthesis inhibitor, lowers lipoprotein (a) in patients with homozygous familial hypercholesterolemia
-
W.C. Cromwell, R.D. Santos, D.J. Blom, D.A. Marais, R.H. Lachmann, and D. Gaudet Mipomersen, a first-in-class apolipoprotein b synthesis inhibitor, lowers lipoprotein (a) in patients with homozygous familial hypercholesterolemia J Clin Lipidol 4 2010 221
-
(2010)
J Clin Lipidol
, vol.4
, pp. 221
-
-
Cromwell, W.C.1
Santos, R.D.2
Blom, D.J.3
Marais, D.A.4
Lachmann, R.H.5
Gaudet, D.6
-
82
-
-
33750207033
-
Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
-
DOI 10.1161/CIRCULATIONAHA.105.606442, PII 0000301720061017000012
-
J.J. Kastelein, M.K. Wedel, B.F. Baker, J. Su, J.D. Bradley, and R.Z. Yu Potent reduction of apolipoprotein b and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein b Circulation 114 2006 1729 1735 (Pubitemid 44607121)
-
(2006)
Circulation
, vol.114
, Issue.16
, pp. 1729-1735
-
-
Kastelein, J.J.P.1
Wedel, M.K.2
Baker, B.F.3
Su, J.4
Bradley, J.D.5
Yu, R.Z.6
Chuang, E.7
Graham, M.J.8
Crooke, R.M.9
-
83
-
-
85041237372
-
Therapy: Antisense inhibitor of apo b has potent lipoprotein effects
-
B.M. Mearns Therapy: antisense inhibitor of apo b has potent lipoprotein effects Nat Rev Cardiol 8 2011 364
-
(2011)
Nat Rev Cardiol
, vol.8
, pp. 364
-
-
Mearns, B.M.1
-
84
-
-
84863397288
-
Pharmacology, target reduction, and drug accumulation after oral feeding of an lna antisense oligonucleotide directed against apo-b 100
-
G.E. Hardee, M. Lindholm, H.F. Hansen, M.R. Moller, H. Orum, and T. Koch Pharmacology, target reduction, and drug accumulation after oral feeding of an lna antisense oligonucleotide directed against apo-b 100 Arterioscler Thromb Vasc Biol 30 2010 e250
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 250
-
-
Hardee, G.E.1
Lindholm, M.2
Hansen, H.F.3
Moller, M.R.4
Orum, H.5
Koch, T.6
-
85
-
-
13944265645
-
Low LDL cholesterol in individuals of african descent resulting from frequent nonsense mutations in pcsk9
-
J. Cohen, A. Pertsemlidis, I.K. Kotowski, R. Graham, C.K. Garcia, and H.H. Hobbs Low LDL cholesterol in individuals of african descent resulting from frequent nonsense mutations in pcsk9 Nat Genet 37 2005 161 165
-
(2005)
Nat Genet
, vol.37
, pp. 161-165
-
-
Cohen, J.1
Pertsemlidis, A.2
Kotowski, I.K.3
Graham, R.4
Garcia, C.K.5
Hobbs, H.H.6
-
86
-
-
34248366942
-
Unravelling the functional significance of PCSK9
-
DOI 10.1097/MOL.0b013e3281338531, PII 0004143320070600000013
-
G. Lambert Unravelling the functional significance of pcsk9 Curr Opin Lipidol 18 2007 304 309 (Pubitemid 46743055)
-
(2007)
Current Opinion in Lipidology
, vol.18
, Issue.3
, pp. 304-309
-
-
Lambert, G.1
-
87
-
-
34547108600
-
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
-
DOI 10.1074/jbc.M702027200
-
D.W. Zhang, T.A. Lagace, R. Garuti, Z. Zhao, M. McDonald, and J.D. Horton Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation J Biol Chem 282 2007 18602 18612 (Pubitemid 47100234)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.25
, pp. 18602-18612
-
-
Zhang, D.-W.1
Lagace, T.A.2
Garuti, R.3
Zhao, Z.4
McDonald, M.5
Horton, J.D.6
Cohen, J.C.7
Hobbs, H.H.8
-
88
-
-
34548163845
-
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
-
DOI 10.1042/BJ20070664
-
J. Li, C. Tumanut, J.A. Gavigan, W.J. Huang, E.N. Hampton, and R. Tumanut Secreted pcsk9 promotes LDL receptor degradation independently of proteolytic activity Biochem J 406 2007 203 207 (Pubitemid 47310950)
-
(2007)
Biochemical Journal
, vol.406
, Issue.2
, pp. 203-207
-
-
Li, J.1
Tumanut, C.2
Gavigan, J.-A.3
Huang, W.-J.4
Hampton, E.N.5
Tumanut, R.6
Suen, K.F.7
Trauger, J.W.8
Spraggon, G.9
Lesley, S.A.10
Liau, G.11
Yowe, D.12
Harris, J.L.13
-
89
-
-
34547137377
-
Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
-
DOI 10.1074/jbc.C700095200
-
M.C. McNutt, T.A. Lagace, and J.D. Horton Catalytic activity is not required for secreted pcsk9 to reduce low density lipoprotein receptors in hepg2 cells J Biol Chem 282 2007 20799 20803 (Pubitemid 47099894)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.29
, pp. 20799-20803
-
-
McNutt, M.C.1
Lagace, T.A.2
Horton, J.D.3
-
90
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
DOI 10.1038/ng1161
-
M. Abifadel, M. Varret, J.P. Rabes, D. Allard, K. Ouguerram, and M. Devillers Mutations in pcsk9 cause autosomal dominant hypercholesterolemia Nat Genet 34 2003 154 156 (Pubitemid 36666925)
-
(2003)
Nature Genetics
, vol.34
, Issue.2
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.-P.3
Allard, D.4
Ouguerram, K.5
Devillers, M.6
Cruaud, C.7
Benjannet, S.8
Wickham, L.9
Erlich, D.10
Derre, A.11
Villeger, L.12
Farnier, M.13
Beucler, I.14
Bruckert, E.15
Chambaz, J.16
Chanu, B.17
Lecerf, J.-M.18
Luc, G.19
Moulin, P.20
Weissenbach, J.21
Prat, A.22
Krempf, M.23
Junien, C.24
Seidah, N.G.25
Boileau, C.26
more..
-
91
-
-
33645103550
-
Sequence variations in pcsk9, low LDL, and protection against coronary heart disease
-
J.C. Cohen, E. Boerwinkle, T.H. Mosley Jr., and H.H. Hobbs Sequence variations in pcsk9, low LDL, and protection against coronary heart disease N Engl J Med 354 2006 1264 1272
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, Jr.T.H.3
Hobbs, H.H.4
-
92
-
-
79952768039
-
A proprotein convertase subtilisin-like/kexin type 9 (pcsk9)-binding antibody that structurally mimics the egf (a) domain of LDL-receptor reduces free circulating pcsk9 and LDL-cholesterol
-
Y.G. Ni, S. Di Marco, J.H. Condra, L.B. Peterson, W. Wang, and F. Wang A proprotein convertase subtilisin-like/kexin type 9 (pcsk9)-binding antibody that structurally mimics the egf (a) domain of LDL-receptor reduces free circulating pcsk9 and LDL-cholesterol J Lipid Res 2010
-
(2010)
J Lipid Res
-
-
Ni, Y.G.1
Di Marco, S.2
Condra, J.H.3
Peterson, L.B.4
Wang, W.5
Wang, F.6
-
93
-
-
78651350647
-
Pcsk9: An emerging target for treatment of hypercholesterolemia
-
C.J. Duff, and N.M. Hooper Pcsk9: an emerging target for treatment of hypercholesterolemia Expert Opin Ther Targets 15 2011 157 168
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 157-168
-
-
Duff, C.J.1
Hooper, N.M.2
-
94
-
-
61449444418
-
Pcsk9 as a therapeutic target of dyslipidemia
-
N.G. Seidah Pcsk9 as a therapeutic target of dyslipidemia Expert Opin Ther Targets 13 2009 19 28
-
(2009)
Expert Opin Ther Targets
, vol.13
, pp. 19-28
-
-
Seidah, N.G.1
-
95
-
-
0036020496
-
3 regulation of cholesterol metabolism in mice
-
DOI 10.1210/me.2002-0009
-
H. Gullberg, M. Rudling, C. Salto, D. Forrest, B. Angelin, and B. Vennstrom Requirement for thyroid hormone receptor beta in t3 regulation of cholesterol metabolism in mice Mol Endocrinol 16 2002 1767 1777 (Pubitemid 34828087)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.8
, pp. 1767-1777
-
-
Gullberg, H.1
Rudling, M.2
Salto, C.3
Forrest, D.4
Angelin, B.5
Vennstrom, B.6
-
96
-
-
0019826837
-
Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyrodism in vivo
-
DOI 10.1073/pnas.78.4.2591
-
G.R. Thompson, A.K. Soutar, F.A. Spengel, A. Jadhav, S.J. Gavigan, and N.B. Myant Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo Proc Natl Acad Sci USA 78 1981 2591 2595 (Pubitemid 11067253)
-
(1981)
Proceedings of the National Academy of Sciences of the United States of America
, vol.78
, Issue.4
, pp. 2591-2595
-
-
Thompson, G.R.1
Soutar, A.K.2
Spengel, F.A.3
-
97
-
-
0013808246
-
The significance of alterations in serum lipids in thyroid dysfunction. II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis
-
K.W. Walton, P.J. Scott, P.W. Dykes, and J.W. Davies The significance of alterations in serum lipids in thyroid dysfunction. II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis Clin Sci 29 1965 217 238
-
(1965)
Clin Sci
, vol.29
, pp. 217-238
-
-
Walton, K.W.1
Scott, P.J.2
Dykes, P.W.3
Davies, J.W.4
-
98
-
-
66149169958
-
Recent developments in hyperthyroidism
-
J. Kharlip, and D.S. Cooper Recent developments in hyperthyroidism Lancet 373 2009 1930 1932
-
(2009)
Lancet
, vol.373
, pp. 1930-1932
-
-
Kharlip, J.1
Cooper, D.S.2
-
99
-
-
0032518922
-
Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1
-
DOI 10.1093/emboj/17.2.455
-
L. Wikstrom, C. Johansson, C. Salto, C. Barlow, A. Campos Barros, and F. Baas Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1 EMBO J 17 1998 455 461 (Pubitemid 28045486)
-
(1998)
EMBO Journal
, vol.17
, Issue.2
, pp. 455-461
-
-
Wikstrom, L.1
Johansson, C.2
Salto, C.3
Barlow, C.4
Barros, A.C.5
Baas, F.6
Forrest, D.7
Thoren, P.8
Vennstrom, B.9
-
100
-
-
0031756642
-
Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor β-deficient mice
-
R.E. Weiss, Y. Murata, K. Cua, Y. Hayashi, H. Seo, and S. Refetoff Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice Endocrinology 139 1998 4945 4952 (Pubitemid 28533441)
-
(1998)
Endocrinology
, vol.139
, Issue.12
, pp. 4945-4952
-
-
Weiss, R.E.1
Murata, Y.2
Cua, K.3
Hayashi, Y.4
Seo, H.5
Refetoff, S.6
-
101
-
-
0033650847
-
Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (cyp7a) response to thyroid hormone but display enhanced resistance to dietary cholesterol
-
H. Gullberg, M. Rudling, D. Forrest, B. Angelin, and B. Vennstrom Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (cyp7a) response to thyroid hormone but display enhanced resistance to dietary cholesterol Mol Endocrinol 14 2000 1739 1749
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1739-1749
-
-
Gullberg, H.1
Rudling, M.2
Forrest, D.3
Angelin, B.4
Vennstrom, B.5
-
102
-
-
38649135692
-
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans
-
DOI 10.1073/pnas.0705286104
-
A. Berkenstam, J. Kristensen, K. Mellström, B. Carlsson, J. Malm, and S. Rehnmark The thyroid hormone mimetic compound kb2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans Proc Natl Acad Sci USA 105 2008 663 667 (Pubitemid 351171765)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.2
, pp. 663-667
-
-
Berkenstam, A.1
Kristensen, J.2
Mellstrom, K.3
Carlsson, B.4
Malm, J.5
Rehnmark, S.6
Garg, N.7
Andersson, C.M.8
Rudling, M.9
Sjoberg, F.10
Angelin, B.11
Baxter, J.D.12
-
103
-
-
77949349469
-
Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia
-
P.W. Ladenson, J.D. Kristensen, E.C. Ridgway, A.G. Olsson, B. Carlsson, and I. Klein Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia N Engl J Med 362 2010 906 916
-
(2010)
N Engl J Med
, vol.362
, pp. 906-916
-
-
Ladenson, P.W.1
Kristensen, J.D.2
Ridgway, E.C.3
Olsson, A.G.4
Carlsson, B.5
Klein, I.6
-
104
-
-
13344279394
-
The squalestatins: Decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors
-
DOI 10.1021/jm9504969
-
C. Chan, D. Andreotti, B. Cox, B.W. Dymock, J.L. Hutson, and S.E. Keeling The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors J Med Chem 39 1996 207 216 (Pubitemid 26023514)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.1
, pp. 207-216
-
-
Chan, C.1
Andreotti, D.2
Cox, B.3
Dymock, B.W.4
Hutson, J.L.5
Keeling, S.E.6
McCarthy, A.D.7
Procopiou, P.A.8
Ross, B.C.9
Sareen, M.10
Scicinski, J.J.11
Sharratt, P.J.12
Snowden, M.A.13
Watson, N.S.14
-
105
-
-
26244432388
-
Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
-
C. Baigent, A. Keech, P.M. Kearney, L. Blackwell, G. Buck, and C. Pollicino Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 2005 1267 1278
-
(2005)
Lancet
, vol.366
, pp. 1267-1278
-
-
Baigent, C.1
Keech, A.2
Kearney, P.M.3
Blackwell, L.4
Buck, G.5
Pollicino, C.6
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