Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4150-4154

  Robinson, Ralph P ^a   Bartlett, Jeremy A ^a   Bertinato, Peter ^a   Bessire, Andrew J ^a   Cosgrove, Judith ^a   Foley, Patrick M ^a   Manion, Tara B ^a   Minich, Martha L ^a   Ramos, Brenda ^a   Reese, Matthew R ^a   Schmahai, Theodore J ^a   Swick, Andrew G ^a   Tess, David A ^a   Vaz, Alfin ^a   Wolford, Angela ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Dirlotapide; Metabolite; MTP; Obesity; Soft drug

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKYL GROUP; DIRLOTAPIDE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; PF 02575799; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG INHIBITION; DRUG SAFETY; DRUG STRUCTURE; FOOD INTAKE; HUMAN; IN VIVO STUDY; NONHUMAN; RAT; SINGLE DRUG DOSE;

AMINOQUINOLINES; ANIMALS; BENZAMIDES; CARBAMATES; CARRIER PROTEINS; DOGS; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MICROSOMES, LIVER; RATS; TRIGLYCERIDES;

RATTUS;

EID: 79959895309     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.099     Document Type: Article

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