메뉴 건너뛰기




Volumn 15, Issue 3, 2010, Pages 433-451

Emerging drugs for hyperlipidemia

Author keywords

Anacetrapib; Apolipoprotein B; Cholesterol ester transfer protein; Dalctetrapib; HDL cholesterol; LDL cholesterol; Lomitapide; Microsomal transfer protein inhibitor; Secretory phospholipase A2

Indexed keywords

AEGR 733; ALEGLITAZAR; ANACETRAPIB; ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; ATORVASTATIN; BILE ACID SEQUESTRANT; BMS 201308; CLOFIBRATE; COLESEVELAM; COLESTYRAMINE; CP 346086; DALCETRAPIB; DIGOXIN; EPROTIROME; EZETEMIBE; EZETIMIBE PLUS SIMVASTATIN; FENOFIBRATE; FLUINDOSTATIN; GEMFIBROZIL; GFT 505; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMPLITAPIDE; LAROPIPRANT; LOMITAPIDE; MEVINOLIN; MIPOMERSEN; MURAGLITIZAR; NICOTINIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; SIMVISTATIN; SUCCINOBUCOL; TESAGLITAZAR; TORCETRAPIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARESPLADIB; WARFARIN;

EID: 77955877432     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2010.481282     Document Type: Review
Times cited : (17)

References (98)
  • 1
    • 0027994593 scopus 로고
    • Established risk factors and coronary artery disease: The Framingham Study
    • Wilson PW. Established risk factors and coronary artery disease: the Framingham Study. Am J Hypertens 1994;7:7S
    • (1994) Am J Hypertens , vol.7
    • Wilson, P.W.1
  • 2
    • 0032510639 scopus 로고    scopus 로고
    • Prediction of coronary heart disease using risk factor categories
    • Wilson PW, D'Agostino RB, Levy D, et al. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837
    • (1998) Circulation , vol.97 , pp. 1837
    • Wilson, P.W.1    D'Agostino, R.B.2    Levy, D.3
  • 3
    • 77955885952 scopus 로고    scopus 로고
    • American Heart Association Statistical Fact Sheet-Risk Factors; 2009 update
    • American Heart Association Statistical Fact Sheet-Risk Factors; 2009 update
  • 4
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein (JUPITER study group)
    • Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein (JUPITER study group). N Engl J Med 2008;359:2195-2207
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.H.3
  • 5
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • (West of Scotland Coronary Study Prevention Group)
    • Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia (West of Scotland Coronary Study Prevention Group). N Engl J Med 1995;333:1301-1307
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 7
    • 0037126729 scopus 로고    scopus 로고
    • Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Third report of the National Cholesterol Education Program (NCEP)
    • Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Circulation 2002;106:3143
    • (2002) Circulation , vol.106 , pp. 3143
  • 8
    • 21444447949 scopus 로고    scopus 로고
    • Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
    • Tsimikas S, Brilakis ES, Miller ER, et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 2005;353:46
    • (2005) N Engl J Med , vol.353 , pp. 46
    • Tsimikas, S.1    Brilakis, E.S.2    Miller, E.R.3
  • 9
    • 0033104713 scopus 로고    scopus 로고
    • Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating 1 integrin
    • Shih PT, Elices MJ, Fang ZT, et al. Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating 1 integrin. J Clin Invest 1999;103:613
    • (1999) J Clin Invest , vol.103 , pp. 613
    • Shih, P.T.1    Elices, M.J.2    Fang, Z.T.3
  • 10
    • 60249101701 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of secretory phospholipase A2 on low density lipoproteins and inflammatory pathways
    • Rosenson RS, Hislop C, McConnell D, et al. Effects of a selective inhibitor of secretory phospholipase A2 on low density lipoproteins and inflammatory pathways. Lancet 2009;373:649-658
    • (2009) Lancet , vol.373 , pp. 649-658
    • Rosenson, R.S.1    Hislop, C.2    McConnell, D.3
  • 12
    • 0036125224 scopus 로고    scopus 로고
    • Hypertriglyceridemia is associated with an elevated blood viscosity Rosenson: Triglycerides and blood viscosity
    • Rosenson RS, Shott S, Tangney CC. Hypertriglyceridemia is associated with an elevated blood viscosity Rosenson: triglycerides and blood viscosity. Atherosclerosis 2002;161:433
    • (2002) Atherosclerosis , vol.161 , pp. 433
    • Rosenson, R.S.1    Shott, S.2    Tangney, C.C.3
  • 13
    • 0032814574 scopus 로고    scopus 로고
    • Low high density lipoprotein levels are associated with an elevated blood viscosity
    • Stamos TD, Rosenson RS. Low high density lipoprotein levels are associated with an elevated blood viscosity. Atherosclerosis 1999;146:161
    • (1999) Atherosclerosis , vol.146 , pp. 161
    • Stamos, T.D.1    Rosenson, R.S.2
  • 14
    • 9544221670 scopus 로고    scopus 로고
    • Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits
    • Duverger N, Kruth H, Emmanuel F, et al. Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits. Circulation 1996;94:713
    • (1996) Circulation , vol.94 , pp. 713
    • Duverger, N.1    Kruth, H.2    Emmanuel, F.3
  • 15
    • 0035818556 scopus 로고    scopus 로고
    • Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: An idea whose time for testing is coming, part i
    • Shah PK, Kaul S, Nilsson J, et al. Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming, part I. Circulation 2001;104:2376
    • (2001) Circulation , vol.104 , pp. 2376
    • Shah, P.K.1    Kaul, S.2    Nilsson, J.3
  • 16
    • 0037327033 scopus 로고    scopus 로고
    • Cholesterol ester transfer protein: A novel for raising HDL and inhibiting atherosclerosis
    • Barter PJ, Brewer HB Jr, Chapman MJ, et al. Cholesterol ester transfer protein: a novel for raising HDL and inhibiting atherosclerosis. Atheroscler Thromb Vasc Biol 2003;23:160-167
    • (2003) Atheroscler Thromb Vasc Biol , vol.23 , pp. 160-167
    • Barter, P.J.1    Brewer Jr., H.B.2    Chapman, M.J.3
  • 17
    • 34748887666 scopus 로고    scopus 로고
    • HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    • Treating to New Targets Investigators
    • Barter P, Gotto AM, LaRossa JC, et al.; for the Treating to New Targets Investigators. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med 2007;357:1301-1310
    • (2007) N Engl J Med , vol.357 , pp. 1301-1310
    • Barter, P.1    Gotto, A.M.2    Larossa, J.C.3
  • 18
    • 38049033935 scopus 로고    scopus 로고
    • CTT Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: A meta-analysis
    • Kearney PM, Blackwell PM, Collins R, et al.; for CTT. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 2008;371:117-125
    • (2008) Lancet , vol.371 , pp. 117-125
    • Kearney, P.M.1    Blackwell, P.M.2    Collins, R.3
  • 19
    • 56349154187 scopus 로고    scopus 로고
    • The residual risk reduction initiative: A call to action to reduce residual vascular risk in patients with dyslipidemia
    • Fruchart JC, Sacks F, Hermans MP, et al. The residual risk reduction initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol 2008;102(Suppl):1K-34K
    • (2008) Am J Cardiol , vol.102 , Issue.SUPPL.
    • Fruchart, J.C.1    Sacks, F.2    Hermans, M.P.3
  • 20
    • 0032054839 scopus 로고    scopus 로고
    • Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease
    • Fibrate consensus group
    • Fruchart JC, Brewer HB Jr, Leitersdorf E, et al. Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate consensus group. Am J Cardiol 1998;81(7):912-917
    • (1998) Am J Cardiol , vol.81 , Issue.7 , pp. 912-917
    • Fruchart, J.C.1    Brewer Jr., H.B.2    Leitersdorf, E.3
  • 21
    • 0032506273 scopus 로고    scopus 로고
    • Mechanism of action of fibrates on lipid and lipoprotein metabolism
    • Staels B, Dallongeville J, Auwerx J, et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98(19):2088-2093
    • (1998) Circulation , vol.98 , Issue.19 , pp. 2088-2093
    • Staels, B.1    Dallongeville, J.2    Auwerx, J.3
  • 22
    • 84920245150 scopus 로고
    • WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: Final mortality follow-up
    • Report of the committee of Principal Investigators
    • WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the committee of Principal Investigators. Lancet 1984;2(8403):600-604
    • (1984) Lancet , vol.2 , Issue.8403 , pp. 600-604
  • 23
    • 35548955508 scopus 로고    scopus 로고
    • The role of fibrates in the prevention of cardiovascular disease- A pooled meta-analysis of long-term randomized placebo-controlled clinical trials
    • Saha SA, Kizhakepunnur LG, Bahekar A, et al. The role of fibrates in the prevention of cardiovascular disease- a pooled meta-analysis of long-term randomized placebo-controlled clinical trials. Am Heart J 2007;154(5):943-953
    • (2007) Am Heart J , vol.154 , Issue.5 , pp. 943-953
    • Saha, S.A.1    Kizhakepunnur, L.G.2    Bahekar, A.3
  • 25
    • 0031909536 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of fibric derivatives (fibrates)
    • Miller DB, Spence JD. Clinical pharmacokinetics of fibric derivatives (fibrates). Clin Pharmacokinet 1998;34(2):155-162
    • (1998) Clin Pharmacokinet , vol.34 , Issue.2 , pp. 155-162
    • Miller, D.B.1    Spence, J.D.2
  • 26
    • 0025365041 scopus 로고
    • Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy
    • Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA 1990;264(1):71-75
    • (1990) JAMA , vol.264 , Issue.1 , pp. 71-75
    • Pierce, L.R.1    Wysowski, D.K.2    Gross, T.P.3
  • 27
    • 0019474574 scopus 로고
    • Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man
    • Grundy SM, Mok HY, Zech L, et al. Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man. J Lipid Res 1981;22(1):24-36
    • (1981) J Lipid Res , vol.22 , Issue.1 , pp. 24-36
    • Grundy, S.M.1    Mok, H.Y.2    Zech, L.3
  • 28
    • 0027963479 scopus 로고
    • Comparative effects of lovastatin and niacin in primary hypercholesterolemia
    • Illingworth DR, Stein EA, Mitchel YB, et al. Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial. Arch Intern Med 1994;154(14):1586-1595
    • (1994) A Prospective Trial. Arch Intern Med , vol.154 , Issue.14 , pp. 1586-1595
    • Illingworth, D.R.1    Stein, E.A.2    Mitchel, Y.B.3
  • 29
    • 0027991884 scopus 로고
    • Nicotinic acid as a lipoprotein-altering agent. Therapy directed by the primary physician
    • Probstfield JL, Hunninghake DB. Nicotinic acid as a lipoprotein-altering agent. Therapy directed by the primary physician. Arch Intern Med 1994;154:1557
    • (1994) Arch Intern Med , vol.154 , pp. 1557
    • Probstfield, J.L.1    Hunninghake, D.B.2
  • 30
    • 0025148561 scopus 로고
    • Nicotinic acid as therapy for dyslipidemia in non-insulin dependent diabetes mellitus
    • Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin dependent diabetes mellitus. JAMA 1990;264(6):723-726
    • (1990) JAMA , vol.264 , Issue.6 , pp. 723-726
    • Garg, A.1    Grundy, S.M.2
  • 31
    • 72049126375 scopus 로고    scopus 로고
    • Statin therapy with ezetimibe or niacin in high-risk patients
    • Kastelein JJP, Bots ML. Statin therapy with ezetimibe or niacin in high-risk patients. N Engl J Med 2009;361:2180-2183
    • (2009) N Engl J Med , vol.361 , pp. 2180-2183
    • Jjp, K.1    Bots, M.L.2
  • 32
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor AJ, Todd CV, Stanek EJ, et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009;361:2113-2122
    • (2009) N Engl J Med , vol.361 , pp. 2113-2122
    • Taylor, A.J.1    Todd, C.V.2    Stanek, E.J.3
  • 33
    • 0021159968 scopus 로고
    • A triglyceride and cholesteryl ester transfer protein associated with liver microsomes
    • Wetterau JR, Zilversmit DB. A triglyceride and cholesteryl ester transfer protein associated with liver microsomes. J Biol Chem 1984;259:10863-10866
    • (1984) J Biol Chem , vol.259 , pp. 10863-10866
    • Wetterau, J.R.1    Zilversmit, D.B.2
  • 34
    • 0025329901 scopus 로고
    • Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex
    • Wetterau JR, Combs KA, Spinner SN, et al. Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. J Biol Chem 1990;265:9800-9807
    • (1990) J Biol Chem , vol.265 , pp. 9800-9807
    • Wetterau, J.R.1    Combs, K.A.2    Spinner, S.N.3
  • 35
    • 0026470990 scopus 로고
    • Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
    • Wetterau JR, Aggerbeck LP, Bouma ME, et al. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 1992;258:999-1001
    • (1992) Science , vol.258 , pp. 999-1001
    • Wetterau, J.R.1    Aggerbeck, L.P.2    Bouma, M.E.3
  • 36
    • 0033826953 scopus 로고    scopus 로고
    • The role of the microsomal triglygeride transfer protein in abetalipoproteinemia
    • Berriot-Varoqueaux N, Aggerbeck LP, Samson-Bouma M, et al. The role of the microsomal triglygeride transfer protein in abetalipoproteinemia. Ann Rev Nutr 2000;20:663-697
    • (2000) Ann Rev Nutr , vol.20 , pp. 663-697
    • Berriot-Varoqueaux, N.1    Aggerbeck, L.P.2    Samson-Bouma, M.3
  • 37
    • 0037244002 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    • Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res 2003;44:22-32
    • (2003) J Lipid Res , vol.44 , pp. 22-32
    • Hussain, M.M.1    Shi, J.2    Dreizen, P.3
  • 38
    • 56549091924 scopus 로고    scopus 로고
    • New approaches to target microsomal triglyceride transfer protein
    • Hussain MM, Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol 2008;19:572-578
    • (2008) Curr Opin Lipidol , vol.19 , pp. 572-578
    • Hussain, M.M.1    Bakillah, A.2
  • 39
    • 0032561425 scopus 로고    scopus 로고
    • An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits
    • Wetterau JR, Gregg RE, Harrity TW, et al. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 1998;282:751-754
    • (1998) Science , vol.282 , pp. 751-754
    • Wetterau, J.R.1    Gregg, R.E.2    Harrity, T.W.3
  • 40
    • 34249825176 scopus 로고    scopus 로고
    • Hepatic and intestinal changes in rats treated with T-0126, a microsomal triglyceride transfer protein (MTP) inhibitor
    • Miyazaki T, Miwa S, Kodama H, et al. Hepatic and intestinal changes in rats treated with T-0126, a microsomal triglyceride transfer protein (MTP) inhibitor. J Toxicol Sci 2007;32:161-177
    • (2007) J Toxicol Sci , vol.32 , pp. 161-177
    • Miyazaki, T.1    Miwa, S.2    Kodama, H.3
  • 41
    • 0242290829 scopus 로고    scopus 로고
    • CP-346086: An MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans
    • Chandler CE, Wilder DE, Pettini JL, et al. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res 2003;44:1887-1901
    • (2003) J Lipid Res , vol.44 , pp. 1887-1901
    • Chandler, C.E.1    Wilder, D.E.2    Pettini, J.L.3
  • 42
    • 19444384186 scopus 로고    scopus 로고
    • Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein e knockout mice fed a Western-type diet: Involvement of the inhibition of postprandial triglyceride elevation
    • Ueshima K, kihisa-Umeno H, Nagayoshi A, et al. Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull 2005;28:247-252
    • (2005) Biol Pharm Bull , vol.28 , pp. 247-252
    • Ueshima, K.1    Kihisa-Umeno, H.2    Nagayoshi, A.3
  • 43
    • 20544474017 scopus 로고    scopus 로고
    • An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
    • Crooke RM, Graham MJ, Lemonidis KM, et al. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. J Lipid Res 2005;46:872-884
    • (2005) J Lipid Res , vol.46 , pp. 872-884
    • Crooke, R.M.1    Graham, M.J.2    Lemonidis, K.M.3
  • 44
    • 66349126280 scopus 로고    scopus 로고
    • PCSK9: A convertase that coordinates LDL catabolism
    • Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res 2009;50:S172-7
    • (2009) J Lipid Res , vol.50
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 45
    • 62649100998 scopus 로고    scopus 로고
    • Abstract 1928: effect of a selective inhibitor of secretory phospholipase A2 on low density and very low density lipoprotein subclasses in stable coronary heart disease patients-PLASMA 2 trial
    • Rosenson RR, Hislop C, Elliot M, et al. Abstract 1928: effect of a selective inhibitor of secretory phospholipase A2 on low density and very low density lipoprotein subclasses in stable coronary heart disease patients-PLASMA 2 trial. Circulation 2008;118:S-406-7
    • (2008) Circulation , vol.118
    • Rosenson, R.R.1    Hislop, C.2    Elliot, M.3
  • 46
    • 0026458932 scopus 로고
    • Inhibition of intimal thickening of the carotid artery of rabbits and of outgrowth of explants of aorta by probucol
    • Shinomiya M, Shirai K, Saito Y, et al. Inhibition of intimal thickening of the carotid artery of rabbits and of outgrowth of explants of aorta by probucol. Atherosclerosis 1992;97:143-148
    • (1992) Atherosclerosis , vol.97 , pp. 143-148
    • Shinomiya, M.1    Shirai, K.2    Saito, Y.3
  • 47
    • 0028806457 scopus 로고
    • Inhibitory effect of a single local probucol administration on neointimal formation in balloon-injured rat carotid artery
    • Ishizaka N, Kurokawa K, Taguchi J, et al. Inhibitory effect of a single local probucol administration on neointimal formation in balloon-injured rat carotid artery. Atherosclerosis 1995;118:53-56
    • (1995) Atherosclerosis , vol.118 , pp. 53-56
    • Ishizaka, N.1    Kurokawa, K.2    Taguchi, J.3
  • 49
    • 0030768434 scopus 로고    scopus 로고
    • Effectiveness of an antioxidant in preventing restenosis after percutaneous transluminal coronary angioplasty: The Probucol Angioplasty Restenosis Trial
    • Yokoi H, Daida H, Kuwabara Y, et al. Effectiveness of an antioxidant in preventing restenosis after percutaneous transluminal coronary angioplasty: the Probucol Angioplasty Restenosis Trial. J Am Coll Cardiol 1997;30:855-862
    • (1997) J Am Coll Cardiol , vol.30 , pp. 855-862
    • Yokoi, H.1    Daida, H.2    Kuwabara, Y.3
  • 50
    • 0037138578 scopus 로고    scopus 로고
    • Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST)
    • Sawayama Y, Shimizu C, Maeda N, et al. Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST). J Am Coll Cardiol 2002;39:610-616
    • (2002) J Am Coll Cardiol , vol.39 , pp. 610-616
    • Sawayama, Y.1    Shimizu, C.2    Maeda, N.3
  • 51
    • 0037417930 scopus 로고    scopus 로고
    • Effects of AGI-1067 and probucol after percutaneous coronary interventions
    • Tardif J, Gregoire J, Schwartz L, et al. Effects of AGI-1067 and probucol after percutaneous coronary interventions. Circulation 2003;107:552-558
    • (2003) Circulation , vol.107 , pp. 552-558
    • Tardif, J.1    Gregoire, J.2    Schwartz, L.3
  • 52
    • 33645741889 scopus 로고    scopus 로고
    • Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Otvos JD, Collin D, Freedman DS, et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 2006;113:1556-1563
    • (2006) Circulation , vol.113 , pp. 1556-1563
    • Otvos, J.D.1    Collin, D.2    Freedman, D.S.3
  • 53
    • 0028849703 scopus 로고
    • Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC-I): Reduction in atherosclerosis progression and clinical events. PLAC i investigation
    • Pitt B, Mancini GB, Rosman HS, et al. Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC-I): reduction in atherosclerosis progression and clinical events. PLAC I investigation. J Am Coll Cardiol 1995;26(5):1133-1139
    • (1995) J Am Coll Cardiol , vol.26 , Issue.5 , pp. 1133-1139
    • Pitt, B.1    Mancini, G.B.2    Rosman, H.S.3
  • 54
    • 44649098307 scopus 로고    scopus 로고
    • Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation
    • Brunzell JD, Davidson M, Furberg CD, et al. Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care 2008;31(4):811-822
    • (2008) Diabetes Care , vol.31 , Issue.4 , pp. 811-822
    • Brunzell, J.D.1    Davidson, M.2    Furberg, C.D.3
  • 55
    • 28144451163 scopus 로고    scopus 로고
    • Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
    • Nissen SE, Wolski K, Topol EJ. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA 2006;295:2581-2586
    • (2006) JAMA , vol.295 , pp. 2581-2586
    • Nissen, S.E.1    Wolski, K.2    Topol, E.J.3
  • 57
    • 0019427798 scopus 로고
    • Cholesterol metabolism in hypothyroidism and hyperthyroidism in man
    • Abrams JJ, Grundy SM. Cholesterol metabolism in hypothyroidism and hyperthyroidism in man. J Lipid Res 1981;22:323-338
    • (1981) J Lipid Res , vol.22 , pp. 323-338
    • Abrams, J.J.1    Grundy, S.M.2
  • 58
    • 9744228694 scopus 로고    scopus 로고
    • Thyroid hormone analogues for the treatment of hypercholesterolemia and heart failure: Past, present, and future prospects
    • Morkin E, Ladenson P, Goldman S, et al. Thyroid hormone analogues for the treatment of hypercholesterolemia and heart failure: past, present, and future prospects. J Mol Cell Cardiol 2004;37:1137-1146
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 1137-1146
    • Morkin, E.1    Ladenson, P.2    Goldman, S.3
  • 59
    • 0025728923 scopus 로고
    • Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density lipoprotein receptor and on acyl-CoA: Cholesterol acyltransferase activities in rat liver
    • Salter AM, Hayashi R, Al-Seeni M, et al. Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density lipoprotein receptor and on acyl-CoA: cholesterol acyltransferase activities in rat liver. Biochem J 1991;276:825-832
    • (1991) Biochem J , vol.276 , pp. 825-832
    • Salter, A.M.1    Hayashi, R.2    Al-Seeni, M.3
  • 60
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 2007;356:148-156
    • (2007) N Engl J Med , vol.356 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 61
    • 48349088178 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
    • Samaha FF, McKenney J, Bloedon LT, et al. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nat Clin Pract Cardiovasc Med 2008;5:497-505
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 497-505
    • Samaha, F.F.1    McKenney, J.2    Bloedon, L.T.3
  • 63
    • 0242290829 scopus 로고    scopus 로고
    • CP-346086: An MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans
    • Chandler CE, Wilder DE, Pettini JL, et al. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res 2003;44:1887-1901
    • (2003) J Lipid Res , vol.44 , pp. 1887-1901
    • Chandler, C.E.1    Wilder, D.E.2    Pettini, J.L.3
  • 64
    • 36348975228 scopus 로고    scopus 로고
    • ILLUMINATE investigators. Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Nicholls S, Rye KA, et al.; for the ILLUMINATE investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007;357(21):2109-22[s5]
    • (2007) N Engl J Med , vol.357 , Issue.21
    • Barter, P.J.1    Nicholls, S.2    Rye, K.A.3
  • 65
    • 34247241088 scopus 로고    scopus 로고
    • Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    • Kastelein JJ, van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007;356:1620
    • (2007) N Engl J Med , vol.356 , pp. 1620
    • Kastelein, J.J.1    Van Leuven, S.I.2    Burgess, L.3
  • 66
    • 58149380516 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibitor torcetrapib and off-target toxicity: A pooled analysis of the rating atherosclerotic disease change by imaging with a new CETP inhibitor (RADIANCE) trials
    • Vergeer M, Bots ML, van Leuven SI, et al. Cholesteryl ester transfer protein inhibitor torcetrapib and off-target toxicity: a pooled analysis of the rating atherosclerotic disease change by imaging with a new CETP inhibitor (RADIANCE) trials. Circulation 2008;118:2515
    • (2008) Circulation , vol.118 , pp. 2515
    • Vergeer, M.1    Bots, M.L.2    Van Leuven, S.I.3
  • 67
    • 34047106220 scopus 로고    scopus 로고
    • Effect of torcetrapib on the progression of coronary atherosclerosis
    • Nissen SE, Tardif JC, Nicholls SJ, et al. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 2007;356:1304
    • (2007) N Engl J Med , vol.356 , pp. 1304
    • Nissen, S.E.1    Tardif, J.C.2    Nicholls, S.J.3
  • 68
    • 58149386896 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: Insights
    • ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation)
    • Nicholls SJ, Tuzcu EM, Brennan DM, et al. Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation 2008;118:2506
    • (2008) Circulation , vol.118 , pp. 2506
    • Nicholls, S.J.1    Tuzcu, E.M.2    Brennan, D.M.3
  • 69
    • 0037035459 scopus 로고    scopus 로고
    • Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomised phase II dose response study
    • de Grooth GJ, Kuivenhoven JA, Stalenhoef AF, et al. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomised phase II dose response study. Circulation 2002;105:2159-2165
    • (2002) Circulation , vol.105 , pp. 2159-2165
    • De Grooth, G.J.1    Kuivenhoven, J.A.2    Stalenhoef, A.F.3
  • 70
    • 17444372760 scopus 로고    scopus 로고
    • Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    • Kuivenhoven JA, de Grooth GJ, Kawamura H, et al. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol 2005;95:1085-1088
    • (2005) Am J Cardiol , vol.95 , pp. 1085-1088
    • Kuivenhoven, J.A.1    De Grooth, G.J.2    Kawamura, H.3
  • 71
    • 67649304458 scopus 로고    scopus 로고
    • Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from 5 phase II clinical trials
    • Stein EA, Stroes ESG, Steiner G, et al. Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from 5 phase II clinical trials. Am J Cardiol 2009;104(1):82-91
    • (2009) Am J Cardiol , vol.104 , Issue.1 , pp. 82-91
    • Stein, E.A.1    Esg, S.2    Steiner, G.3
  • 72
    • 36549078679 scopus 로고    scopus 로고
    • Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: Two double-blind, randomised placebo-controlled phase i studies
    • Krishna R, Anderson MS, Bergman AJ, et al. Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies. Lancet 2007;370:1907
    • (2007) Lancet , vol.370 , pp. 1907
    • Krishna, R.1    Anderson, M.S.2    Bergman, A.J.3
  • 73
    • 58649091088 scopus 로고    scopus 로고
    • Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
    • Bloomfield D, Carlson GL, Sapre A, et al. Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients. Am Heart J 2009;157:352
    • (2009) Am Heart J , vol.157 , pp. 352
    • Bloomfield, D.1    Carlson, G.L.2    Sapre, A.3
  • 74
    • 0027994776 scopus 로고
    • Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits
    • Ameli S, Hultgardh-Nilsson A, Cercek B, et al. Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits. Circulation 1994;90:1935
    • (1994) Circulation , vol.90 , pp. 1935
    • Ameli, S.1    Hultgardh-Nilsson, A.2    Cercek, B.3
  • 75
    • 0242577955 scopus 로고    scopus 로고
    • Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
    • Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA 2003;290:2292
    • (2003) JAMA , vol.290 , pp. 2292
    • Nissen, S.E.1    Tsunoda, T.2    Tuzcu, E.M.3
  • 76
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • Kastelein JJ, Wedel MK, Baker BF, et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006;114:1729
    • (2006) Circulation , vol.114 , pp. 1729
    • Kastelein, J.J.1    Wedel, M.K.2    Baker, B.F.3
  • 77
    • 77951072532 scopus 로고    scopus 로고
    • Effect of ApoB synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
    • In press
    • Visser ME, Akdim F, Tribble DL, et al. Effect of ApoB synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J Lipid Res. In press
    • J Lipid Res
    • Visser, M.E.1    Akdim, F.2    Tribble, D.L.3
  • 78
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen an apolipoprotein B synthesis inhibitor for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolemia: A randomized double-blind placebo-controlled trial
    • Raal EF, Santos RD, Blom DJ, et al. Mipomersen an apolipoprotein B synthesis inhibitor for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial. Lancet 2010;375(9719):998-1006
    • (2010) Lancet , vol.375 , Issue.9719 , pp. 998-1006
    • Raal, E.F.1    Santos, R.D.2    Blom, D.J.3
  • 79
    • 77955857180 scopus 로고    scopus 로고
    • Press release Genzyme February 2010
    • Press release Genzyme February 2010
  • 80
    • 34247397359 scopus 로고    scopus 로고
    • Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: A randomized controlled trial
    • Tardif JC, Gregoire J, L'Allier PL, et al. Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial. JAMA 2007;297:1675
    • (2007) JAMA , vol.297 , pp. 1675
    • Tardif, J.C.1    Gregoire, J.2    L'Allier, P.L.3
  • 81
    • 60249099795 scopus 로고    scopus 로고
    • Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice
    • Fraser H, Hislop C, Christie RM, et al. Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice. J Cardiovasc Pharmacol 2009;53:60-65
    • (2009) J Cardiovasc Pharmacol , vol.53 , pp. 60-65
    • Fraser, H.1    Hislop, C.2    Christie, R.M.3
  • 82
    • 67449127221 scopus 로고    scopus 로고
    • The synergistic inhibition of atherogenesis in ApoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)
    • Shaposhnik Z, Wang X, Trias J, et al. The synergistic inhibition of atherogenesis in ApoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). J Lipid Res 2008;50:623-629
    • (2008) J Lipid Res , vol.50 , pp. 623-629
    • Shaposhnik, Z.1    Wang, X.2    Trias, J.3
  • 83
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubin D, Koren M, Davidson M, et al. Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 2009;104:74-81
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • MacCubin, D.1    Koren, M.2    Davidson, M.3
  • 84
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/ laropiprant in patients with primary hypercholesterolemia or mixed dyslipidemia
    • Maccubin D, Bays HE, Olsson AG, et al. Lipid-modifying efficacy and tolerability of extended-release niacin/ laropiprant in patients with primary hypercholesterolemia or mixed dyslipidemia. Int J Clin Practice 2008;62(12):1959-1970
    • (2008) Int J Clin Practice , vol.62 , Issue.12 , pp. 1959-1970
    • MacCubin, D.1    Bays, H.E.2    Olsson, A.G.3
  • 85
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003;34:154-156
    • (2003) Nat Genet , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 86
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005;37(2):161-165
    • (2005) Nat Genet , vol.37 , Issue.2 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3
  • 87
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006;354:1264-1273
    • (2006) N Engl J Med , vol.354 , pp. 1264-1273
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3
  • 88
    • 33344464808 scopus 로고    scopus 로고
    • A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
    • Kotowski IK, Pertsemlidis A, Luke R, et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Human Genet 2006;78:410-422
    • (2006) Am J Human Genet , vol.78 , pp. 410-422
    • Kotowski, I.K.1    Pertsemlidis, A.2    Luke, R.3
  • 89
    • 0037417930 scopus 로고    scopus 로고
    • Effects of AGI-1067 and probucol after percutaneous coronary interventions
    • Canadian Antioxidant Restenosis Trial (CART-1) Investigators
    • Tardif JC, Gregoire J, Schwartz L, et al.; for the Canadian Antioxidant Restenosis Trial (CART-1) Investigators. Effects of AGI-1067 and probucol after percutaneous coronary interventions. Circulation 2003;107:552-558
    • (2003) Circulation , vol.107 , pp. 552-558
    • Tardif, J.C.1    Gregoire, J.2    Schwartz, L.3
  • 90
    • 2442670243 scopus 로고    scopus 로고
    • Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
    • Leren TP. Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. Clin Genet 2004;65:419-422
    • (2004) Clin Genet , vol.65 , pp. 419-422
    • Leren, T.P.1
  • 91
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge KE, Ose L, Leren TP. Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Artrerioscler Thromb Vasc Biol 2006;26:1094-1100
    • (2006) Artrerioscler Thromb Vasc Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 92
    • 67649839953 scopus 로고    scopus 로고
    • Effect of the dual peroxisome proliferator-activated receptor-alpha/ gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): A phase II, randomised, dose-ranging study
    • Henry RR, Lincoff AM, Mudaliar S, et al. Effect of the dual peroxisome proliferator-activated receptor-alpha/ gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study. Lancet 2009;374(9684):96-98
    • (2009) Lancet , vol.374 , Issue.9684 , pp. 96-98
    • Henry, R.R.1    Lincoff, A.M.2    Mudaliar, S.3
  • 93
    • 77955889374 scopus 로고    scopus 로고
    • Press release Genfit November 23, 2009
    • Press release Genfit November 23, 2009
  • 95
    • 43849103005 scopus 로고    scopus 로고
    • Effects of succinobucol (AGI-1067) after an acute coronary syndrome: A randomised, doubleblind, placebo-controlled trial
    • Tardif JC, McMurray JJ, Klug E, et al. Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, doubleblind, placebo-controlled trial. Lancet 2008;371:1761-1768
    • (2008) Lancet , vol.371 , pp. 1761-1768
    • Tardif, J.C.1    McMurray, J.J.2    Klug, E.3
  • 96
    • 77949349469 scopus 로고    scopus 로고
    • Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia
    • Ladenson PW, Kristensen JD, Ridgway EC, et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 2010;362:906-916
    • (2010) N Engl J Med , vol.362 , pp. 906-916
    • Ladenson, P.W.1    Kristensen, J.D.2    Ridgway, E.C.3
  • 97
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987;317:1237-1245
    • (1987) N Engl J Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 98
    • 0027987849 scopus 로고
    • Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandanavian Simvistatin Survival Study (4S)
    • Scandinavian Simvistatin Survival Group
    • Scandinavian Simvistatin Survival Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandanavian Simvistatin Survival Study (4S). Lancet 1994;344(8934):1383-1389
    • (1994) Lancet , vol.344 , Issue.8934 , pp. 1383-1389


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.