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Volumn 19, Issue 6, 2011, Pages 1930-1949
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Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
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Author keywords
2 Aminobenzhydrol; Hypercholesterolemia; Intramolecular hydrogen bond; Squalene synthase inhibitor; X ray analysis
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Indexed keywords
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N ETHYLPIPERIDINE 4 CARBOXAMIDE;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N ISOPROPYLPIPERIDINE 4 CARBOXAMIDE;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N METHYLPIPERIDINE 4 CARBOXAMIDE;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N,N DIMETHYLPIPERIDINE 4 CARBOXAMIDE;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 3 CARBOXYLIC ACID;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXAMIDE;
1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
2 AMINOBENZHYDROL;
4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOIC ACID;
4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOIC ACID;
BENZYL 4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZINE 1 CARBOXYLIC ACID;
ETHYL 1 [3 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPROPANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 3 CARBOXYLIC ACID;
ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL](METHYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL](PROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 1 [5 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPENTANOYL]PIPERIDINE 4 CARBOXYLIC ACID;
ETHYL 4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZINE 1 CARBOXYLIC CID;
ETHYL 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOIC AICD;
ETHYL 5 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPENTANOIC ACID;
ETHYL [4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZIN 1 YL]ACETIC ACID;
METHYL 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOIC ACID;
N [4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL] N (2,2 DIMETHYLPROPYL) 4 [4 (METHYLSULFONYL)PIPERAZIN 1 YL] 4 OXOBUTANAMIDE;
N [4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL] N' (CYCLOHEXYMETHYL) N (2,2 DIMETHYLPROPYL)SUCCINAMIDE;
N BUTYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXAMIDE;
SQUALENE SYNTHASE;
SQUALENE SYNTHASE INHIBITOR;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ARTICLE;
BIOTRANSFORMATION;
CHEMICAL BINDING;
CHEMICAL INTERACTION;
CONFORMATIONAL TRANSITION;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
ENZYME ACTIVE SITE;
HYDROGEN BOND;
STRUCTURE ACTIVITY RELATION;
X RAY CRYSTALLOGRAPHY;
BENZHYDRYL COMPOUNDS;
BINDING SITES;
CATALYTIC DOMAIN;
CRYSTALLOGRAPHY, X-RAY;
DRUG EVALUATION, PRECLINICAL;
ENZYME INHIBITORS;
FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE;
HYDROGEN BONDING;
MOLECULAR CONFORMATION;
PIPERIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 79952442829
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2011.01.065 Document Type: Article |
Times cited : (25)
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References (27)
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