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Volumn 19, Issue 6, 2011, Pages 1930-1949

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

Author keywords

2 Aminobenzhydrol; Hypercholesterolemia; Intramolecular hydrogen bond; Squalene synthase inhibitor; X ray analysis

Indexed keywords

1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N ETHYLPIPERIDINE 4 CARBOXAMIDE; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N ISOPROPYLPIPERIDINE 4 CARBOXAMIDE; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N METHYLPIPERIDINE 4 CARBOXAMIDE; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL] N,N DIMETHYLPIPERIDINE 4 CARBOXAMIDE; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 3 CARBOXYLIC ACID; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXAMIDE; 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; 2 AMINOBENZHYDROL; 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOIC ACID; 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOIC ACID; BENZYL 4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZINE 1 CARBOXYLIC ACID; ETHYL 1 [3 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPROPANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 3 CARBOXYLIC ACID; ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL](METHYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL](PROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [5 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPENTANOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZINE 1 CARBOXYLIC CID; ETHYL 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)CARBONYL]PHENYL]AMINO] 4 OXOBUTANOIC AICD; ETHYL 5 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 5 OXOPENTANOIC ACID; ETHYL [4 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERAZIN 1 YL]ACETIC ACID; METHYL 4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOIC ACID; N [4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL] N (2,2 DIMETHYLPROPYL) 4 [4 (METHYLSULFONYL)PIPERAZIN 1 YL] 4 OXOBUTANAMIDE; N [4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL] N' (CYCLOHEXYMETHYL) N (2,2 DIMETHYLPROPYL)SUCCINAMIDE; N BUTYL 1 [4 [[4 CHLORO 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]PHENYL](2,2 DIMETHYLPROPYL)AMINO] 4 OXOBUTANOYL]PIPERIDINE 4 CARBOXAMIDE; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79952442829     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.065     Document Type: Article
Times cited : (25)

References (27)
  • 8
    • 0010521788 scopus 로고    scopus 로고
    • One of the original squalene synthase inhibitors, zaragozic acid A, caused acidosis in rats and dogs; however, the adverse effect was not shown in monkeys. It might be species-dependent toxicity. Please refer the following articles: S.A. Biller, K. Neuenschwander, M.M. Ponpipom, and C.D. Poulter Curr. Pharm. Des. 2 1996 1
    • (1996) Curr. Pharm. Des. , vol.2 , pp. 1
    • Biller, S.A.1    Neuenschwander, K.2    Ponpipom, M.M.3    Poulter, C.D.4
  • 19
    • 79952441482 scopus 로고    scopus 로고
    • (JP 2001/354587). The atomic coordinates have been deposited with Protein Data Bank (PDB code: 3Q30 and 3Q2Z)
    • Usui, H.; Katakura, S.; Suzuki, M. Jpn. Kokai Tokkyo Koho. 2001, 131 (JP 2001/354587). The atomic coordinates have been deposited with Protein Data Bank (PDB code: 3Q30 and 3Q2Z).
    • (2001) Jpn. Kokai Tokkyo Koho. , vol.131
    • Usui, H.1    Katakura, S.2    Suzuki, M.3
  • 27
    • 79952440523 scopus 로고    scopus 로고
    • The atomic coordinates have been deposited with Protein Data Bank (PDB code: 3ASX)
    • The atomic coordinates have been deposited with Protein Data Bank (PDB code: 3ASX).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.