A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3727-3730

  Tollefson, Michael B ^a   Kolodziej, Stephen A ^a   Fletcher, Theresa R ^a   Vernier, William F ^a   Beaudry, Judith A ^a   Keller, Bradley T ^a   Reitz, David B ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BENZOTHIAZEPINE DERIVATIVE; 5 ARYL 3,3 DIBUTYL 7 (DIMETHYLAMINO) 1,2 BENZODIAZEPIN 4 OL 1,1 DIOXIDE; ANTILIPEMIC AGENT; SODIUM CODEPENDENT BILE ACID TRANSPORTER INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HYPERLIPIDEMIA; IN VITRO STUDY;

EID: 0141545117     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.004     Document Type: Article

References (11)

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9. 2).
10. For a discussion of the cis selectivity, see: Wang C.-C., Li J.J., Huang H.-C., Lee L.F., Reitz D.B. J. Org. Chem. 65:2000;2711.
11. 2. After the incubation period, the plates were decanted and each well washed twice with ice-cold phosphate-buffered saline (PBS) containing 0.1% fatty-acid free BSA followed by one time with straight PBS. Each well received 200 μL Microscint-20 and a clear plastic heat seal was placed over the top of the plate. The radioactivity in each well was counted in a Packard TopCount scintillation counter.