Thyroid hormone receptor β-deficient mice show complete loss of the normal cholesterol 7α-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol

Molecular Endocrinology

Volumn 14, Issue 11, 2000, Pages 1739-1749

  Gullberg, H ^a   Rudling, M ^a   Forrest, D ^a   Angelin, B ^a   Vennstrom, B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; LIOTHYRONINE; MESSENGER RNA; THYROID HORMONE; THYROID HORMONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL INTAKE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERCHOLESTEROLEMIA; HYPOTHYROIDISM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM;

EID: 0033650847     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.11.0548     Document Type: Article

References (45)

1. Approach to the patient with hyperlipidemia
2. Disorders of lipid metabolism
3. Secondary causes of hyperlipidemia
4. Hyperlipidemia in patients with primary and secondary hypothyroidism
5. A receptor-mediated pathway for cholesterol homeostasis
6. Causes and treatment of hypercholesterolemia
7. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
8. Studies on the regulation of hepatic cholesterol metabolism in humans
9. Effects of the thyroid state on cholesterol metabolism in the rat
10. Stimulation of hepatic β-hydroxy-β-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine
11. Effect of thyroid hormone on hepatic cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats
12. Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats
13. Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats
14. Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7α-hydroxylase mRNA and the CYP7 gene in HepG2 cells
15. Hormonal regulation of cholesterol 7α-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat
16. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice
17. The mouse as a model for human cardiovascular disease and hyperlipidemia
18. Bile acid biosynthesis
19. Coordinate regulation of HMG CoA reductase and cholesterol 7α-hydroxylase
20. Effect of cholesterol feeding on apo B and apo E concentrations and distributions in euthyroid and hypothyroid rats
21. Studies on the etiology of increased tissue cholesterol concentration in cholesterol-fed hypothyroid rats
22. Growth hormone and bile acid synthesis: Key role for the activity of hepatic microsomal cholesterol 7α-hydroxylase in the rat
23. Loss of resistance to dietary cholesterol in the rat following hypophysectomy: Importance of growth hormone for the expression of hepatic low density lipoprotein receptors
24. The nuclear receptor superfamily: The second decade
25. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
26. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
27. Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1
28. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: Evidence for tissue-specific modulation of receptor function
29. Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity
30. Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor β-deficient mice
31. Variation in susceptibility to atherosclerosis among inbred strains of mice
32. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α
33. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
34. Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-l gene expression
35. Plasma high-density lipoproteins and atherosclerosis
36. Effects of thyroid status and fasting on hepatic metabolism of apolipoprotein A-l
37. Hormonal regulation of apolipoprotein Al
38. Nuclear orphan receptors control cholesterol catabolism
39. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
40. Identification of a nuclear receptor for bile acids
41. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
42. Thyroid hormone rapidly increases cholesterol 7α-hydroxylase mRNA levels in hypophysectomized rats
43. Beneficial effects of a novel thyromimetic on lipoprotein metabolism
44. Cholesterol metabolism in hypothyroidism and hyperthyroidism in man