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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 6929-6932

Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure-activity studies and in vivo efficacy

(9) Howell, Kobporn L a Devita, Robert J a Garcia Calvo, Margarita a Meurer, Roger D a Lisnock, Jeanmarie a Bull, Herbert G a McMasters, Daniel R a McCann, Margaret E a Mills, Sander G a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

Cholesterol absorption inhibitor; Ezetimibe; Hypercholesterolemia; Niemann Pick C1 Like 1 protein; Spiroimidazolidinone

Indexed keywords

EZETIMIBE; IMIDAZOLE DERIVATIVE; NIEMANN PICK C1 LIKE 1 PROTEIN; SPIROIMIDAZOLIDINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRUSH BORDER; CELL STRAIN HEK293; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG EFFICACY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AZETIDINES; IMIDAZOLES; INTESTINAL ABSORPTION; MEMBRANE TRANSPORT PROTEINS; MICE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 78149281356 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.09.138 Document Type: Article

Times cited : (18)

References (17)

1
- 0036206190
- R.E. Ostlund Curr. Opin. Gastroenterol. 18 2002 254
- (2002) Curr. Opin. Gastroenterol. , vol.18 , pp. 254
- Ostlund, R.E.¹

2
- 0032510318
- S.B. Rosenblum, T. Huynh, A. Afonso, H.R. Davis Jr., N. Yumibe, J.W. Clader, and D.A. Burnett J. Med. Chem. 41 1998 973
- (1998) J. Med. Chem. , vol.41 , pp. 973
- Rosenblum, S.B.¹ Huynh, T.² Afonso, A.³ Davis Jr., H.R.⁴ Yumibe, N.⁵ Clader, J.W.⁶ Burnett, D.A.⁷

3
- 17944380533
- H.E. Bays, P.B. Moore, M.A. Drehobl, S. Rosenblatt, P.D. Toth, C.A. Dujovne, R.H. Knopp, L.J. Lipka, A.P. LeBeaut, B. Yang, L.E. Mellars, C. Cuffie-Jackson, and E.P. Veltri Clin. Ther. 23 2001 1209
- (2001) Clin. Ther. , vol.23 , pp. 1209
- Bays, H.E.¹ Moore, P.B.² Drehobl, M.A.³ Rosenblatt, S.⁴ Toth, P.D.⁵ Dujovne, C.A.⁶ Knopp, R.H.⁷ Lipka, L.J.⁸ Lebeaut, A.P.⁹ Yang, B.¹⁰ Mellars, L.E.¹¹ Cuffie-Jackson, C.¹² Veltri, E.P.¹³

4
- 0030848734
- M. van Heek, C.F. France, D.S. Compton, R.L. McLeod, N.P. Yumibe, K.B. Alton, E.J. Sybertz, and H.R. Davis Jr. J. Pharmacol. Exp. Ther. 283 1997 157
- (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 157
- Van Heek, M.¹ France, C.F.² Compton, D.S.³ McLeod, R.L.⁴ Yumibe, N.P.⁵ Alton, K.B.⁶ Sybertz, E.J.⁷ Davis Jr., H.R.⁸

5
- 20444371945
- M. Garcia-Calvo, J.M. Lisnock, H.G. Bull, B.E. Hawes, D.A. Burnett, M.P. Braun, J.H. Crona, H.R. Davis Jr., D.C. Dean, P.A. Detmers, M.P. Graziano, M. Hughes, D.E. MacIntyre, A. Ogawa, K.A. O'Neill, S.P.N. Iyer, D.E. Shevell, M.M. Smith, Y.S. Tang, A.M. Makarewicz, F. Ujjainwalla, S.W. Altmann, K.T. Chapman, and N.A. Thornberry Proc. Natl. Acad. Sci. U.S.A. 102 2005 8132
- (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 8132
- Garcia-Calvo, M.¹ Lisnock, J.M.² Bull, H.G.³ Hawes, B.E.⁴ Burnett, D.A.⁵ Braun, M.P.⁶ Crona, J.H.⁷ Davis Jr., H.R.⁸ Dean, D.C.⁹ Detmers, P.A.¹⁰ Graziano, M.P.¹¹ Hughes, M.¹² MacIntyre, D.E.¹³ Ogawa, A.¹⁴ O'Neill, K.A.¹⁵ Iyer, S.P.N.¹⁶ Shevell, D.E.¹⁷ Smith, M.M.¹⁸ Tang, Y.S.¹⁹ Makarewicz, A.M.²⁰ more..

6
- 0035458847
- Y.A. Ioannou Nat. Rev. Mol. Cell Biol. 2 2001 657
- (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 657
- Ioannou, Y.A.¹

7
- 4043124013
- H.R. Davis Jr., L.-J. Zhu, L.M. Hoos, G. Tetzloff, M. Maguire, J. Liu, X. Yao, S.P.N. Iyer, M.-H. Lam, E.G. Lund, P.A. Detmers, M.P. Graziano, and S.W. Altmann J. Biol. Chem. 279 2004 33586
- (2004) J. Biol. Chem. , vol.279 , pp. 33586
- Davis Jr., H.R.¹ Zhu, L.-J.² Hoos, L.M.³ Tetzloff, G.⁴ Maguire, M.⁵ Liu, J.⁶ Yao, X.⁷ Iyer, S.P.N.⁸ Lam, M.-H.⁹ Lund, E.G.¹⁰ Detmers, P.A.¹¹ Graziano, M.P.¹² Altmann, S.W.¹³

8
- 10744221008
- S.W. Altmann, H.R. Davis Jr., L.-J. Zhu, X. Yao, L.M. Hoos, G. Tetzloff, S.P.N. Iyer, M. Maguire, A. Golovko, M. Zeng, L. Wang, N. Murgolo, and M. Graziano Science 303 2004 1201
- (2004) Science , vol.303 , pp. 1201
- Altmann, S.W.¹ Davis Jr., H.R.² Zhu, L.-J.³ Yao, X.⁴ Hoos, L.M.⁵ Tetzloff, G.⁶ Iyer, S.P.N.⁷ Maguire, M.⁸ Golovko, A.⁹ Zeng, M.¹⁰ Wang, L.¹¹ Murgolo, N.¹² Graziano, M.¹³

9
- 33750308356
- A.T. Sané, D. Sinnett, E. Delvin, M. Bendayan, V. Marcil, D. Ménard, J.-F. Beaulieu, and E. Levy J. Lipid Res. 47 2006 2112
- (2006) J. Lipid Res. , vol.47 , pp. 2112
- Sané, A.T.¹ Sinnett, D.² Delvin, E.³ Bendayan, M.⁴ Marcil, V.⁵ Ménard, D.⁶ Beaulieu, J.-F.⁷ Levy, E.⁸

10
- 0034003105
- M. van Heek, C. Farley, D.S. Compton, L. Hoos, K.B. Alton, E.J. Sybertz, and H.R. Davis Jr. Br. J. Pharmacol. 129 2000 1748
- (2000) Br. J. Pharmacol. , vol.129 , pp. 1748
- Van Heek, M.¹ Farley, C.² Compton, D.S.³ Hoos, L.⁴ Alton, K.B.⁵ Sybertz, E.J.⁶ Davis Jr., H.R.⁷

11
- 18344380806
- J.E. Patrick, T. Kosoglou, K.L. Stauber, K.B. Alton, S.E. Mazwell, Y. Zhu, P. Statkevich, R. Iannucci, S. Chowdhury, M. Affrime, and M.N. Cayen Drug Metab. Dispos. 30 2002 430
- (2002) Drug Metab. Dispos. , vol.30 , pp. 430
- Patrick, J.E.¹ Kosoglou, T.² Stauber, K.L.³ Alton, K.B.⁴ Mazwell, S.E.⁵ Zhu, Y.⁶ Statkevich, P.⁷ Iannucci, R.⁸ Chowdhury, S.⁹ Affrime, M.¹⁰ Cayen, M.N.¹¹

12
- 78149280040
- Submitted for publication
- Garcia-Calvo, M. et al., submitted for publication.
- Garcia-Calvo, M.¹

13
- 33845872811
- B.E. Hawes, K.A. O'Neill, X. Yao, J.H. Crona, H.R. Davis Jr., M.P. Graziano, and S.W. Altmann Mol. Pharmacol. 71 2007 19
- (2007) Mol. Pharmacol. , vol.71 , pp. 19
- Hawes, B.E.¹ O'Neill, K.A.² Yao, X.³ Crona, J.H.⁴ Davis Jr., H.R.⁵ Graziano, M.P.⁶ Altmann, S.W.⁷

14
- 65149099897
- D.R. McMasters, M. Garcia-Calvo, V. Mairorov, M.E. McCann, R.D. Meurer, H.G. Bull, J.-M. Lisnock, K.L. Howell, and R.J. DeVita Bioorg. Med. Chem. Lett. 19 2009 2965
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2965
- McMasters, D.R.¹ Garcia-Calvo, M.² Mairorov, V.³ McCann, M.E.⁴ Meurer, R.D.⁵ Bull, H.G.⁶ Lisnock, J.-M.⁷ Howell, K.L.⁸ Devita, R.J.⁹

15
- 78149285219
- WO 033431
- Burnett, D.; McKittrick, B. A., WO 033431, 2008.
- (2008)
- Burnett, D.¹ McKittrick, B.A.²

16
- 38149037904
- J.A. Pfefferkorn, S.D. Larsen, C. Van Huis, R. Sorenson, T. Barton, T. Winters, B. Auerbach, C. Wu, T.J. Wolfram, H. Cai, K. Welch, N. Esmaiel, J. Davis, R. Bousley, K. Olsen, S.B. Mueller, and T. Mertz Bioorg. Med. Chem. Lett. 18 2008 546
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 546
- Pfefferkorn, J.A.¹ Larsen, S.D.² Van Huis, C.³ Sorenson, R.⁴ Barton, T.⁵ Winters, T.⁶ Auerbach, B.⁷ Wu, C.⁸ Wolfram, T.J.⁹ Cai, H.¹⁰ Welch, K.¹¹ Esmaiel, N.¹² Davis, J.¹³ Bousley, R.¹⁴ Olsen, K.¹⁵ Mueller, S.B.¹⁶ Mertz, T.¹⁷

17
- 68349127059
- J.P. Simeone, M.P. Braun, J.F. Leone, P. Lin, R.J. DeVita, M. Garcia-Calvo, H.G. Bull, J.M. Lisnock, and D.C. Dean Bioorg. Med. Chem. Lett. 19 2009 5033
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5033
- Simeone, J.P.¹ Braun, M.P.² Leone, J.F.³ Lin, P.⁴ Devita, R.J.⁵ Garcia-Calvo, M.⁶ Bull, H.G.⁷ Lisnock, J.M.⁸ Dean, D.C.⁹

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