Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: Cholesterol acyltransferase and lipid peroxidation

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 8, 2010, Pages 1066-1076

  Ohta, Masaru ^a,b   Takahashi, Kenji ^a   Kasai, Masayasu ^a   Shoji, Yoshimichi ^a   Kunishiro, Kazuyoshi ^a   Miike, Tomohiro ^a   Kanda, Mamoru ^a   Mukai, Chisato ^b   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Acyl CoA: cholesterol acyltransferase; Foam cell formation; Lipid peroxidation; Oxidative stress induced cell death; Pactimibe; Tetrahydroisoquinoline

Indexed keywords

7 DIMETHYLAMINO N (4 HYDROXY 2,3,5 TRIMETHYLPHENYL) 2 ISOBUTYRYL 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PACTIMIBE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CELL DEATH; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FOAM CELL; IC 50; IN VITRO STUDY; LIPID PEROXIDATION; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIOXIDANTS; CELL DEATH; CHOLESTEROL; DOGS; ENZYME INHIBITORS; ESTERIFICATION; LIPID PEROXIDATION; MACROPHAGES; MALE; MOLECULAR STRUCTURE; OXIDATIVE STRESS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 77955363537     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.1066     Document Type: Article

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