Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 23203-23215

  Liew, Chong Wai ^a   Nilsson, Martina ^a   Chen, Ming Wei ^a   Sun, Huihua ^a   Cornvik, Tobias ^a   Liang, Zhao Xun ^a   Lescar, Julien ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL GROUPS; ACETYL-COA; ACYL CARRIER PROTEINS; ACYL GROUP; CARBOXYLATE GROUPS; CATALYTIC DOMAINS; COCRYSTALLIZATION; COVALENT COMPLEX; DYNEMICIN; ENEDIYNES; EVOLUTIONARY RELATIONSHIPS; FATTY ACID SYNTHASE; MALONATES; MALONYL-COA; NATURAL PRODUCTS; NON-POLAR; POLYKETIDE SYNTHASES; POLYKETIDES; STRUCTURAL DIFFERENCES; SUB-DOMAINS; SUBDOMAIN; SUBSTRATE SPECIFICITY;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; COBALT COMPOUNDS; CRYSTAL STRUCTURE; ENZYMATIC HYDROLYSIS; KETONES; ORGANIC COMPOUNDS;

PLANTS (BOTANY);

ACYLTRANSFERASE; ALPHA HYDROLASE; ARGININE; BETA HYDROLASE; ENEDIYNE; FATTY ACID SYNTHASE; HISTIDINE; HYDROLASE; MALONIC ACID DERIVATIVE; MALONYL COENZYME A; POLYKETIDE SYNTHASE; SELENOMETHIONINE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MICROMONOSPORA; MICROMONOSPORA CHERSINA; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

ACETYL COENZYME A; ACYLTRANSFERASES; AMINO ACID MOTIFS; ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; CLONING, MOLECULAR; CRYSTALLOGRAPHY; ENEDIYNES; GLYCEROL; MICROMONOSPORA; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

MICROMONOSPORA CHERSINA;

EID: 84863304168     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.362210     Document Type: Article

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