Structure and mechanism of the trans -Acting acyltransferase from the disorazole synthase

Biochemistry

Volumn 50, Issue 30, 2011, Pages 6539-6548

  Wong, Fong T ^a   Jin, Xi ^b   Mathews, Irimpan I ^c   Cane, David E ^d   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETATE COMPLEXES; ACTIVE SITE; ACYL CARRIER PROTEINS; ALANINE-SCANNING MUTAGENESIS; HIGH RESOLUTION ANALYSIS; POLYKETIDE SYNTHASES; PROTEIN-PROTEIN INTERFACE; SUBSTRATE SPECIFICITY; SYNTHASES; WILD TYPES; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; KETONES; PLANTS (BOTANY); PROTEINS; SUBSTRATES;

CRYSTAL STRUCTURE;

ACETIC ACID; ACYL CARRIER PROTEIN; ACYLTRANSFERASE; ALANINE; ASPARTIC ACID; BACTERIAL ENZYME; CYSTEINE; DISORAZOLE SYNTHASE; POLYKETIDE; SERINE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; STREPTOMYCES COELICOLOR; X RAY CRYSTALLOGRAPHY;

ACYL CARRIER PROTEIN; ACYLTRANSFERASES; ALANINE; AMINO ACID SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHETASE COMPLEX; MACROLIDES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXAZOLES; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES COELICOLOR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79960812401     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200632j     Document Type: Article

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