Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15739-15749

  Kotaka, Masayo ^a,b   Kong, Rong ^a   Qureshi, Insaf ^a   Ho, Qin Shi ^a   Sun, Huihua ^a   Liew, Chong Wai ^a   Goh, Lan Pei ^a   Cheung, Peter ^a   Mu, Yuguang ^a   Lescar, Julien ^a   Liang, Zhao Xun ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; ANTI-TUMOR; CALICHEAMICIN; CATALYTIC MECHANISMS; CATALYTIC RESIDUE; CIS-DOUBLE BONDS; COMPUTATIONAL DOCKING; DOUBLE BONDS; ENEDIYNE; KETOCARBOXYLIC ACIDS; NATURAL PRODUCTS; POLYKETIDE BIOSYNTHESIS; POLYKETIDE SYNTHASE; SITE DIRECTED MUTAGENESIS; SUBSTRATE-BINDING; THIOESTER; THIOESTERASE; THIOESTERASES; TYPE II; WATER NETWORKS; X RAY CRYSTAL STRUCTURES;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; ENZYMES; HYDROGEN; ORGANIC COMPOUNDS; SUBSTRATES;

CRYSTAL STRUCTURE;

ARGININE; BETA KETOCARBOXYLIC ACID; CARBOXYLIC ACID; ENEDIYNE; POLYKETIDE; THIOL ESTER HYDROLASE; THIOL ESTER HYDROLASE CALE7; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTINEOPLASTIC AGENT; CALICHEAMICIN THETA(1)I; CARBAZOLE DERIVATIVE; FATTY ACID SYNTHASE; POLYKETIDE SYNTHASE; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; THIOESTERASE II;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; HYDROGEN BOND; HYDROLYSIS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PH; PROTEIN CONFORMATION; SYNTHESIS;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTINEOPLASTIC AGENTS; ARGININE; BINDING SITES; CARBAZOLES; CATALYSIS; CONSERVED SEQUENCE; ENEDIYNES; FATTY ACID SYNTHETASE COMPLEX; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; THIOLESTER HYDROLASES;

EID: 67650138601     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809669200     Document Type: Article

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