Induced-fit upon Ligand Binding Revealed by Crystal Structures of the Hot-dog Fold Thioesterase in Dynemicin Biosynthesis

Journal of Molecular Biology

Volumn 404, Issue 2, 2010, Pages 291-306

  Liew, Chong Wai ^a   Sharff, Andrew ^b   Kotaka, Masayo ^a,d   Kong, Rong ^a   Sun, Huihua ^a   Qureshi, Insaf ^a   Bricogne, Gérard ^b   Liang, Zhao Xun ^a   Lescar, Julien ^a,c  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b GLOBAL PHASING LTD   (United Kingdom)

^c Centre National de la Recherche Scientifique   (France)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Allosteric effect; Enediyne; Hot dog fold; Polyketide biosynthesis; Thioesterase

Indexed keywords

ARGININE; DYNEMICIN; DYNEMICIN E7; DYNEMICIN E8; ENEDIYNE; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL;

CANIS FAMILIARIS; MICROMONOSPORA;

EID: 78349306683     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.09.041     Document Type: Article

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