Deleterious network hypothesis of Alzheimer's disease

Medical Hypotheses

Volumn 46, Issue 5, 1996, Pages 421-428

  Ying, W ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; FREE RADICAL;

ALZHEIMER DISEASE; CALCIUM HOMEOSTASIS; ENERGY METABOLISM; HUMAN; HYPOTHESIS; PEROXIDATION; PRIORITY JOURNAL; PROTEIN METABOLISM; REVIEW;

EID: 0029930021     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(96)90021-3     Document Type: Article

References (21)

1. Katzman R, Saitoh T. Advances in Alzheimer's disease. FASEB J 1991; 5: 278-286.
2. St. George-Hyslop P H, Haines J L, Farrer L A et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 1990; 347: 194-197.
3. Amaducci L, Falcini M, Lippi A. Descriptive epidemiology and risk factors for Alzheimer's disease. Acta Neurol Scand Suppl 1992; 139: 21-25.
4. Henderson A S. The risk factors for Alzheimer's disease: a review and a hypothesis. Acta Psychiatr Scand 1988; 78: 257-275.
5. Rosenberg R N. A causal role for amyloid in Alzheimer's disease: the end of the beginning. Neurology 1993; 43: 851-856.
6. Lai F, Williams R S. A prospective study of Alzheimer's disease in Down syndrome. Arch Neurol 1989; 46: 849-853.
7. Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P. Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology 1994; 44: 342-344.
8. Zhang Y, Tatsuno T, Carney J M, Mattson M P. Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J Cereb Blood Flow Metab 1993; 13: 378-388.
9. Mecocci P, MacGarvey U, Beal M F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 1994; 36: 741-751.
10. Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K. Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J Biol Chem 1992; 267: 18210-18217.
11. Behl C, Davis J B, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994; 77: 817-827.
12. Braughler J M, Hall E D. Central nervous system trauma and stroke. Free Radic Biol Med 1989; 6: 289-301.
13. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59: 527-605.
14. Subbarao K V, Richardson J S, Ang L C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 1990; 55: 342-345.
15. Dowson J H. Neuronal lipofuscin accumulation in aging and Alzheimer's dementia: a pathogenic mechanism? Br J Psychiatr 1982; 140:142-148.
16. Cheng B, Mattson M P. Glucose deprivation elicits neurofibrillary tangles-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF. Exp Neurol 1992; 117: 114-123.
17. Evans P H, Klinowski J, Yano E. Cephaloconiosis: a free radical perspective on the proposed particulate-induced etiopathogenesis of Alzheimer's dementia and related disorders. Med Hypotheses 1991; 34: 209-219.
18. Friedlich A L, Butcher L L. Involvement of free oxygen radicals in beta-amyloidosis: an hypothesis. Neurobiol Aging 1994; 15: 443-455.
19. Okunade W G, Olorunsogo O O. Effect of reactive oxygen species on the erythrocyte calcium-pump function in protein-energy malnutrition. Biosci Rep 1992; 12: 433-443.
20. Smith C D, Carney J M, Starke-Reed P E et al. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci USA 1991; 88: 10540-10543.
21. Baumhuter S, Richter C. The hydroperoxide-induced release of mitochondrial calcium occurs via a distinct pathway and leaves mitochondria intact. FEBS Lett 1982; 148: 271-275.