Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pathway

European Journal of Neuroscience

Volumn 24, Issue 8, 2006, Pages 2169-2176

  Cai, Ai Li ^a   Zipfel, Gregory J ^a   Sheline, Christian T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Global ischemia; Mouse; Neuroprotection; Nicotinamide

Indexed keywords

2 HYDROXYNAPHTHALDEHYDE; 3 ACETYLPYRIDINE; ALDEHYDE DERIVATIVE; FISETIN; HYDROLASE INHIBITOR; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; RESVERATROL; SIRTINOL; SIRTUIN; UNCLASSIFIED DRUG; ZINC;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL CULTURE; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG EFFECT; INTRACELLULAR SPACE; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALDEHYDES; ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CELLS, CULTURED; FLAVONOIDS; ION CHANNELS; MALE; MITOCHONDRIA; NAD; NAPHTHALENES; NEURAL CONDUCTION; NEUROTOXICITY SYNDROMES; NEUROTOXINS; NIACINAMIDE; PYRIDINES; RATS; RATS, LONG-EVANS; SIGNAL TRANSDUCTION; SIRTUINS; STILBENES; TRANS-ACTIVATION (GENETICS); ZINC;

EID: 33750362174     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05110.x     Document Type: Article

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