Insights into inflammation and epilepsy from the basic and clinical sciences

Journal of Clinical Neuroscience

Volumn 19, Issue 8, 2012, Pages 1071-1075

  Silveira, Gustavo ^a   De Oliveira, Antonio Carlos Pinheiro ^a   Teixeira, Antonio Lucio ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Cytokines; Epilepsy; Immunology; Inflammation

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DIAZEPAM; DIPYRONE; GLUCOCORTICOID; IBUPROFEN; INDOMETACIN; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PENTETRAZOLE; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ANTICONVULSANT ACTIVITY; BLOOD BRAIN BARRIER; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SAFETY; ENDOCYTOSIS; EPILEPSY; EPILEPTOGENESIS; EXOCYTOSIS; GENETIC TRANSCRIPTION; HUMAN; IMMUNOREACTIVITY; INFLAMMATION; INNATE IMMUNITY; MICROGLIA; NERVE EXCITABILITY; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TEMPORAL LOBE EPILEPSY; TONIC CLONIC SEIZURE; UPREGULATION;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; EPILEPSY; HIPPOCAMPUS; HUMANS;

EID: 84863087606     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2011.10.011     Document Type: Review

References (84)

1. Teixeira AL, Bauer ME, Nicolato R, et al. In: Sergei V. Fedorovich, editor. Signal Transduction in Nervous Cells. p. 95-115 (Research Signpost, 2011).
2. S.M. Allan, P.J. Tyrrell, and N.J. Rothwell Interleukin-1 and neuronal injury Nat Rev Immunol 5 2005 629 640
3. P. Scalzo, A. Kummer, and F. Cardoso Increased serum levels of soluble tumor necrosis factor-alpha receptor-1 in patients with Parkinson's disease J Neuroimmunol 216 2009 122 125
4. I.G. Barbosa, R.B. Huguet, and F.S. Neves Immunology of bipolar disorder J Bras Psiquiatr 58 2009 52 59
5. F.M. Coelho, H.J. Reis, and R. Nicolato Increased serum levels of inflammatory markers in chronic institutionalized patients with schizophrenia Neuroimmunomodulation 15 2008 140 144
6. R. Grassi-Oliveira, E. Brietzke, and J.C. Pezzi Increased soluble tumor necrosis factor-alpha receptors in patients with major depressive disorder Psychiatry Clin Neurosci 63 2009 202 208
7. A. Vezzani, S. Balosso, and T. Ravizza The role of cytokines in the pathophysiology of epilepsy Brain Behav Immun 22 2008 797 803
8. M.G. De Simoni, C. Perego, and T. Ravizza Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus Eur J Neurosci 12 2000 2623 2633
9. E.A. Johnson, and R.K. Kan The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations J Neuroinflammation 7 2010 40
10. M. Minami, Y. Kuraishi, and M. Satoh Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain Biochem Biophys Res Commun 176 1991 593 598
11. T. Ravizza, B. Gagliardi, and F. Noe Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy Neurobiol Dis 29 2008 142 160
12. X. Luo, D. Li, and D. Cen Effect of intravenous immunoglobulin treatment on brain interferon-gamma and interleukin-6 levels in a rat kindling model Epilepsy Res 88 2010 162 167
13. M. Penkowa, A. Molinero, and J. Carrasco Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures Neuroscience 102 2001 805 818
14. J.T. Jarvela, F.R. Lopez-Picon, and A. Plysjuk Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus J Neuroinflammation 8 2011 29
15. C.R. Plata-Salaman, S.E. Ilyin, and N.P. Turrin Kindling modulates the IL-1beta system, TNF-alpha, TGF-beta1, and neuropeptide mRNAs in specific brain regions Brain Res Mol Brain Res 75 2000 248 258
16. C.B. Lawrence, S.M. Allan, and N.J. Rothwell Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat Eur J Neurosci 10 1998 1188 1195
17. Y. Yamasaki, N. Matsuura, and H. Shozuhara Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats Stroke 26 1995 676 680 [discussion 81]
18. C.M. Dube, T. Ravizza, and M. Hamamura Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers J Neurosci 30 2010 7484 7494
19. M. Fukuda, Y. Suzuki, and Y. Ishizaki Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats Seizure 18 2009 211 214
20. A. Vezzani, M. Conti, and A. De Luigi Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures J Neurosci 19 1999 5054 5065
21. P.K. Panegyres, and J. Hughes The neuroprotective effects of the recombinant interleukin-1 receptor antagonist rhIL-1ra after excitotoxic stimulation with kainic acid and its relationship to the amyloid precursor protein gene J Neurol Sci 154 1998 123 132
22. S. Auvin, D. Shin, and A. Mazarati Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA Epilepsia 51 Suppl. 3 2010 34 38
23. N. Marchi, Q. Fan, and C. Ghosh Antagonism of peripheral inflammation reduces the severity of status epilepticus Neurobiol Dis 33 2009 171 181
24. M. Maroso, S. Balosso, and T. Ravizza Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice Neurotherapeutics 8 2011 304 315
25. T. Ravizza, F. Noe, and D. Zardoni Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production Neurobiol Dis 31 2008 327 333
26. A. Vezzani, D. Moneta, and C. Richichi Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis Epilepsia 43 Suppl. 5 2002 30 35
27. M. Sayyah, S. Beheshti, and M.A. Shokrgozar Antiepileptogenic and anticonvulsant activity of interleukin-1 beta in amygdala-kindled rats Exp Neurol 191 2005 145 153
28. G. Li, S. Bauer, and M. Nowak Cytokines and epilepsy Seizure 20 2011 249 256
29. S. Balosso, T. Ravizza, and C. Perego Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors Ann Neurol 57 2005 804 812
30. A.J. Bruce, W. Boling, and M.S. Kindy Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors Nat Med 2 1996 788 794
31. H. Samland, S. Huitron-Resendiz, and E. Masliah Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6 J Neurosci Res 73 2003 176 187
32. M.A. Galic, K. Riazi, and J.G. Heida Postnatal inflammation increases seizure susceptibility in adult rats J Neurosci 28 2008 6904 6913
33. S. Sinha, S.A. Patil, and V. Jayalekshmy Do cytokines have any role in epilepsy? Epilepsy Res 82 2008 171 176
34. S. Liimatainen, M. Fallah, and E. Kharazmi Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy J Neurol 256 2009 796 802
35. A. Yamamoto, C.K. Schindler, and B.M. Murphy Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy Exp Neurol 202 2006 410 420
36. K. Yoshikawa, Y. Kita, and K. Kishimoto Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2 J Biol Chem 281 2006 14663 14669
37. K.H. Jung, K. Chu, and S.T. Lee Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus Neurobiol Dis 23 2006 237 246
38. E.J. Baik, E.J. Kim, and S.H. Lee Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus Brain Res 843 1999 118 129
39. T. Kunz, and E.H. Oliw Nimesulide aggravates kainic acid-induced seizures in the rat Pharmacol Toxicol 88 2001 271 276
40. L. Holtman, E.A. van Vliet, and P.M. Edelbroek Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy Epilepsy Res 91 2010 49 56
41. P. Desjardins, A. Sauvageau, and A. Bouthillier Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis Neurochem Int 42 2003 299 303
42. B. Viviani, S. Bartesaghi, and F. Gardoni Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases J Neurosci 23 2003 8692 8700
43. S. Hu, W.S. Sheng, and L.C. Ehrlich Cytokine effects on glutamate uptake by human astrocytes Neuroimmunomodulation 7 2000 153 159
44. T. Fellin, M. Gomez-Gonzalo, and S. Gobbo Astrocytic glutamate is not necessary for the generation of epileptiform neuronal activity in hippocampal slices J Neurosci 26 2006 9312 9322
45. S. Wang, Q. Cheng, and S. Malik Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons J Pharmacol Exp Ther 292 2000 497 504
46. D. Stellwagen, E.C. Beattie, and J.Y. Seo Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha J Neurosci 25 2005 3219 3228
47. M. Penkowa, M. Giralt, and N. Lago Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury Exp Neurol 181 2003 130 148
48. T. Ravizza, and A. Vezzani Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system Neuroscience 137 2006 301 308
49. E.A. van Vliet, S. da Costa Araujo, and S. Redeker Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy Brain 130 2007 521 534
50. C.C. Ferrari, A.M. Depino, and F. Prada Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain Am J Pathol 165 2004 1827 1837
51. E. Seiffert, J.P. Dreier, and S. Ivens Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex J Neurosci 24 2004 7829 7836
52. S. Ivens, D. Kaufer, and L.P. Flores TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis Brain 130 2007 535 547
53. M.L. Foresti, G.M. Arisi, and K. Katki Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus J Neuroinflammation 6 2009 40
54. J.H. Xu, L. Long, and Y.C. Tang CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) Neuropathol Appl Neurobiol 35 2009 496 514
55. S.I. Yeo, J.E. Kim, and H.J. Ryu The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus J Neuroimmunol 234 2011 93 102
56. L. Librizzi, M.C. Regondi, and C. Pastori Expression of adhesion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro Epilepsia 48 2007 743 751
57. P.F. Fabene, G. Navarro Mora, and M. Martinello A role for leukocyte-endothelial adhesion mechanisms in epilepsy Nat Med 14 2008 1377 1383
58. J.F. Tellez-Zenteno, S. Matijevic, and S. Wiebe Somatic comorbidity of epilepsy in the general population in Canada Epilepsia 46 2005 1955 1962
59. M. Sayyah, M. Javad-Pour, and M. Ghazi-Khansari The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice. involvement of proinflammatory factors: nitric oxide and prostaglandins Neuroscience 122 2003 1073 1080
60. R.S. Rao, B. Medhi, and U.N. Saikia Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat Eur Neuropsychopharmacol 18 2008 760 767
61. K. Riazi, M.A. Galic, and J.B. Kuzmiski Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation Proc Natl Acad Sci USA 105 2008 17151 17156
62. J. Hulkkonen, E. Koskikallio, and S. Rainesalo The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients Epilepsy Res 59 2004 199 205
63. J. Peltola, J. Palmio, and L. Korhonen Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures Epilepsy Res 41 2000 205 211
64. R. Kiefer, D. Lindholm, and G.W. Kreutzberg Interleukin-6 and transforming growth factor-beta 1 mRNAs are induced in rat facial nucleus following motoneuron axotomy Eur J Neurosci 5 1993 775 781
65. K.A. Lehtimaki, T. Keranen, and H. Huhtala Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration J Neuroimmunol 152 2004 121 125
66. K.A. Lehtimaki, T. Keranen, and J. Palmio Levels of IL-1beta and IL-1ra in cerebrospinal fluid of human patients after single and prolonged seizures Neuroimmunomodulation 17 2010 19 22
67. E.A. Proper, A.B. Oestreicher, and G.H. Jansen Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy Brain 123 2000 19 30
68. J.G. Sheng, F.A. Boop, and R.E. Mrak Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity J Neurochem 63 1994 1872 1879
69. P.F. Fabene, P. Bramanti, and G. Constantin The emerging role for chemokines in epilepsy J Neuroimmunol 224 2010 22 27
70. K.L. van Gassen, M. de Wit, and M.J. Koerkamp Possible role of the innate immunity in temporal lobe epilepsy Epilepsia 49 2008 1055 1065
71. J. Choi, D.R. Nordli Jr., and T.D. Alden Cellular injury and neuroinflammation in children with chronic intractable epilepsy J Neuroinflammation 6 2009 38
72. A. Crespel, P. Coubes, and M.C. Rousset Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis Brain Res 952 2002 159 169
73. C.A. Pardo, E.P. Vining, and L. Guo The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomies Epilepsia 45 2004 516 526
74. N. Polascheck, M. Bankstahl, and W. Loscher The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy Exp Neurol 224 2010 219 233
75. A. Dhir, P.S. Naidu, and S.K. Kulkarni Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice Clin Exp Pharmacol Physiol 32 2005 574 584
76. A. Dhir, P.S. Naidu, and S.K. Kulkarni Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice Seizure 16 2007 691 697
77. M.S. Oliveira, A.F. Furian, and L.M. Rambo Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors Neuroscience 152 2008 1110 1118
78. M.S. Oliveira, A.F. Furian, and L.F. Royes Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures Epilepsy Res 79 2008 14 21
79. R. Kaminski, M. Kozicka, and J. Parada-turska Effect of non-steroidal anti-inflammatory drugs on the anticonvulsive activity of valproate and diphenylhydantoin against maximal electroshock-induced seizures in mice Pharmacol Res 37 1998 375 381
80. A. Vezzani, J. French, and T. Bartfai The role of inflammation in epilepsy Nat Rev Neurol 7 2011 31 40
81. N. Marchi, T. Granata, and E. Freri Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics PLoS ONE 6 2011 e18200
82. V.L. Smith-Swintosky, L.C. Pettigrew, and R.M. Sapolsky Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures J Cereb Blood Flow Metab 16 1996 585 598
83. B.A. Stein, and R.M. Sapolsky Chemical adrenalectomy reduces hippocampal damage induced by kainic acid Brain Res 473 1988 175 180
84. K. Dinkel, A. MacPherson, and R.M. Sapolsky Novel glucocorticoid effects on acute inflammation in the CNS J Neurochem 84 2003 705 716