Effect of intravenous immunoglobulin treatment on brain interferon-gamma and interleukin-6 levels in a rat kindling model

Epilepsy Research

Volumn 88, Issue 2-3, 2010, Pages 162-167

  Luo, Xiangyang ^a   Li, Dongfang ^a   Cen, Danyang ^a   He, Zhanwen ^a   Meng, Zhe ^a   Liang, Liyang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Epilepsy; Interferon ; Interleukin 6; Intravenous immunoglobulin; Kindling; Neuron specific enolase; Rat

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 6; NEURON SPECIFIC ENOLASE; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; HIPPOCAMPUS; KINDLING; LATENT PERIOD; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT; SEIZURE; TISSUE HOMOGENATE; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOGLOBULINS, INTRAVENOUS; INTERFERON-GAMMA; INTERLEUKIN-6; KINDLING, NEUROLOGIC; MALE; PHOSPHOPYRUVATE HYDRATASE; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES; SEVERITY OF ILLNESS INDEX;

EID: 75849154257     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2009.10.014     Document Type: Article

References (28)

1. Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2 (2001) 675-680
2. Ariizumi M., Baba K., Shiihara H., Ogawa K., Hibio S., Suzuki Y., Ryo S., and Momoki T. High dose gammaglobulin for intractable childhood epilepsy. Lancet 2 (1983) 162-163
3. Billiau A.D., Witters P., Ceulemans B., Kasran A., Wouters C., and Lagae L. Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profile. Epilepsia 48 (2007) 1739-1749
4. Correale J., Rabinowicz A.L., Heck C.N., Smith T.D., Loskota W.J., and DeGiorgio C.M. Status epilepticus increases CSF levels of neuron-specific enolase and alters the blood-brain barrier. Neurology 50 (1998) 1388-1391
5. De Sarro G., Russo E., Ferreri G., Giuseppe B., Flocco M.A., Di Paola E.D., and De Sarro A. Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice. Pharmacol. Biochem. Behav. 77 (2004) 761-766
6. DeGiorgio C.M., Gott P.S., Rabinowicz A.L., Heck C.N., Smith T.D., and Correale J.D. Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus. Epilepsia 37 (2005) 606-609
7. Diehl R.G., Smialowski A., and Gotwo T. Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs. Epilepsia 25 (1984) 506-510
8. Hulse R.E., Kunkler P.E., Fedynyshyn J.P., and Kraig R.P. Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue. J. Neurosci. Methods 136 (2004) 87-98
9. Kalueff A.V., Lehtimaki K.A., Ylinen A., Honkaniemi J., and Peltola J. Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats. Neurosci. Lett. 365 (2004) 106-110
10. Kawakami Y., Fukunaga Y., Kuwabara K., Fujita T., Fujino O., and Hashimoto K. Clinical and immunological significance of neopterin measurement in cerebrospinal fluid in patients with febrile convulsions. Brain Dev. 21 (1999) 458-460
11. Lehtimäki K.A., Peltola J., Koskikallio E., Keränen T., and Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res. Mol. Brain Res. 110 (2003) 253-260
12. Lehtimäki K.A., Keränen T., Huhtala H., Hurme M., Ollikainen J., Honkaniemi J., Palmio J., and Peltola J. Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration. J. Neuroimmunol. 152 (2004) 121-125
13. Li G.Q., Lin Z.D., Jiao Y., Shi X.L., Ye X.Y., and Hu H.W. Changes of serum and cerebrospinal fluid neuron-specific enolase. S100β and myelin basic protein levels in children with epilepsy after seizures. Chin. J. Contemp. Pediatr. 6 (2004) 500-503
14. Li, X., Renzhe, A.N., 2005. Change of the production of INF-γ, IL-10 in peripheral blood mononuclear cells from convulsion rats and the influence of immunoglobulin on it. A thesis for the degree of master of pediatrics in Clinic of Yanbian University Medical College.
15. Ling Z.D., Yeoh E., Webb B.T., Farrell K., Doucette J., and Matheson D.S. Intravenous immunoglobulin induces interferon-gamma and interleukin-6 in vivo. J. Clin. Immunol. 13 (1993) 302-309
16. Marangos P.J., Schmechel D., Parma A.M., Clark R.L., and Goodwin F.K. Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue. J Neurochem. 33 (1979) 319-329
17. Mikati M.A., and Shamseddine A.N. Management of Landau-Kleffner syndrome. Paediatr. Drugs 7 (2005) 377-389
18. Müller M., Fontana A., Zbinden G., and Gähwiler B.H. Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures. Brain Res. 619 (1993) 157-162
19. Najjar S., Bernbaum M., Lai G., and Devinsky O. Immunology and epilepsy. Rev. Neurol. Dis. 5 (2008) 109-116
20. Oses J.P., Leke R., Portela L.V., Lara D.R., Schmidt A.P., Casali E.A., Wofchuk S., Souza D.O., and Sarkis J.J.F. Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Brain Res. Bull. 64 (2004) 237-242
21. Péchadre J.C., Sauvezie B., Osier C., and Gibert J. The treatment of epileptic encephalopathies with gamma globulin in children (author's transl.). Rev. Electroencephalogr. Neurophysiol. Clin. 7 (1977) 443-447 In French
22. Renzhe A.N., Yan G.H., Piao D.M., Yin Y.R., and Chi Y.X. Effects of immunoglobulin on the neuronal expression of IL-1beta and IL-1ra and the neuronal death at hippocampus in rats with convulsion induced by pentylenetetrazol. Zhonghua Er Ke Za Zhi 43 (2005) 849-851 (in Chinese)
23. Royds J.A., Parsons M.A., Taylor C.B., and Timperley W.R. Enolase isoenzyme distribution in the human brain and its tumours. J. Pathol. 137 (1982) 37-49
24. Shiihara H., Michihiro N., Sakuta R., Saga T., Ojima K., and Ariizumi M. Changes in the lymphocyte subsets during high dose immunoglobulin therapy for intractable childhood epilepsy. Psychiatry Clin. Neurosci. 49 (1995) S251-S253
25. Sternberg J.M., Rodgers J., Bradley B., Maclean L., Murray M., and Kennedy P.G. Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. J. Neuroimmunol. 167 (2005) 81-89
26. Turrin N.P., and Rivest S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol. Dis. 16 (2004) 321-334
27. van Engelen B.G., Renier W.O., Weemaes C.M., Gabreels F.J., and Meinardi H. Immunoglobulin treatment in epilepsy, a review of the literature. Epilepsy Res. 19 (1994) 181-190
28. Xiaoqin Z., Zhengli L., Changgeng Z., Xiaojing W., and Li L. Changes in behavior and amino acid neurotransmitters in the brain of rats with seizure induced by IL-1beta or IL-6. J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2005) 236-239