The acute phase response and soman-induced status epilepticus: Temporal, regional and cellular changes in rat brain cytokine concentrations

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Johnson, Erik A ^a   Kan, Robert K ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; SOMAN; TUMOR NECROSIS FACTOR ALPHA; CONVULSANT AGENT;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN REGION; CELL ENLARGEMENT; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; EPILEPTIC STATE; HIPPOCAMPUS; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LONG TERM EXPOSURE; MALE; MICROGLIA; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PYRIFORM CORTEX; QUANTITATIVE ANALYSIS; RAT; THALAMUS; UPREGULATION; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; HISTOLOGY; HUMAN; IMMUNOLOGY; METABOLISM; METHODOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT;

ACUTE-PHASE REACTION; ANIMALS; BRAIN; CONVULSANTS; CYTOKINES; HUMANS; IMMUNOASSAY; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; RATS; RATS, SPRAGUE-DAWLEY; SOMAN; STATUS EPILEPTICUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954805268     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-40     Document Type: Article

References (50)

1. Marrs TC, Maynard RL, Sidell FR. Chemical warfare agents: toxicology and treatment 2007, Chichester, West Sussex, England; Hoboken, NJ: Wiley, 2.
2. McDonough JH, Shih TM. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 1997, 21:559-579. 10.1016/S0149-7634(96)00050-4, 9353792.
3. Koplovitz I, Skvorak JP. Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats. Epilepsy Res 1998, 30:159-164. 10.1016/S0920-1211(97)00100-9, 9600547.
4. Zimmer LA, Ennis M, Shipley MT. Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions. J Comp Neurol 1997, 378:482-492. 10.1002/(SICI)1096-9861(19970224)378:4<482::AID-CNE4>3.0.CO;2-Z, 9034905.
5. Baille V, Clarke PG, Brochier G, Dorandeu F, Verna JM, Four E, Lallement G, Carpentier P. Soman-induced convulsions: the neuropathology revisited. Toxicology 2005, 215:1-24. 10.1016/j.tox.2005.05.028, 16054742.
6. McLeod CG, Singer AW, Harrington DG. Acute neuropathology in soman poisoned rats. Neurotoxicology 1984, 5:53-57.
7. Dhote F, Peinnequin A, Carpentier P, Baille V, Delacour C, Foquin A, Lallement G, Dorandeu F. Prolonged inflammatory gene response following soman-induced seizures in mice. Toxicology 2007, 238:166-176. 10.1016/j.tox.2007.05.032, 17662515.
8. Dillman JF, Phillips CS, Kniffin DM, Tompkins CP, Hamilton TA, Kan RK. Gene expression profiling of rat hippocampus following exposure to the acetylcholinesterase inhibitor soman. Chem Res Toxicol 2009, 22:633-638. 10.1021/tx800466v, 19281266.
9. Svensson I, Waara L, Johansson L, Bucht A, Cassel G. Soman-induced interleukin-1 beta mRNA and protein in rat brain. Neurotoxicology 2001, 22:355-362. 10.1016/S0161-813X(01)00022-5, 11456336.
10. Williams AJ, Berti R, Yao C, Price RA, Velarde LC, Koplovitz I, Schultz SM, Tortella FC, Dave JR. Central neuro-inflammatory gene response following soman exposure in the rat. Neurosci Lett 2003, 349:147-150. 10.1016/S0304-3940(03)00818-8, 12951190.
11. Li L, Lu J, Tay SS, Moochhala SM, He BP. The function of microglia, either neuroprotection or neurotoxicity, is determined by the equilibrium among factors released from activated microglia in vitro. Brain Res 2007, 1159:8-17. 10.1016/j.brainres.2007.04.066, 17572395.
12. Patzer A, Zhao Y, Stock I, Gohlke P, Herdegen T, Culman J. Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. Eur J Neurosci 2008, 28:1786-1794. 10.1111/j.1460-9568.2008.06478.x, 18973594.
13. Vezzani A, Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005, 46:1724-1743. 10.1111/j.1528-1167.2005.00298.x, 16302852.
14. Wallenstein MC. Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. Exp Neurol 1987, 98:152-160. 10.1016/0014-4886(87)90080-X, 3115810.
15. Feuerstein GZ, Wang X, Barone FC. Inflammatory gene expression in cerebral ischemia and trauma. Potential new therapeutic targets. Ann N Y Acad Sci 1997, 825:179-193. 10.1111/j.1749-6632.1997.tb48428.x, 9369986.
16. Toulmond S, Parnet P, Linthorst AC. When cytokines get on your nerves: cytokine networks and CNS pathologies. Trends Neurosci 1996, 19:409-410.
17. Wang CX, Shuaib A. Involvement of inflammatory cytokines in central nervous system injury. Prog Neurobiol 2002, 67:161-172. 10.1016/S0301-0082(02)00010-2, 12126659.
18. Relton JK, Rothwell NJ. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull 1992, 29:243-246. 10.1016/0361-9230(92)90033-T, 1388088.
19. Patkai J, Mesples B, Dommergues MA, Fromont G, Thornton EM, Renauld JC, Evrard P, Gressens P. Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res 2001, 50:222-230. 10.1203/00006450-200108000-00010, 11477207.
20. Holmin S, Mathiesen T. Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edema. J Neurosurg 2000, 92:108-120. 10.3171/jns.2000.92.1.0108, 10616089.
21. Stroemer RP, Rothwell NJ. Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat. J Cereb Blood Flow Metab 1998, 18:833-839. 10.1097/00004647-199808000-00003, 9701344.
22. Dhote F, Peinnequin A, Carpentier P, Baille V, Delacour C, Foquin A, Lallement G, Dorandeu F. Soman-Induced Neuro-Inflammatory Reaction in Mouse Brain. Some Effects of a Combination of Atropine and Ketamine. Defence against the Effects of Chemical Hazards: Toxicology, Diagnosis and Medical Countermeasures RTO-MP-HFM-149, Paper 2; Edinborough, Scotland 2007, 2-1-2-20.
23. Svensson I, Waara L, Cassel G. Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain. Neurotoxicology 2005, 26:173-181. 10.1016/j.neuro.2004.11.004, 15713338.
24. Shih TM, McDonough JH. Neurochemical mechanisms in soman-induced seizures. J Appl Toxicol 1997, 17:255-264. 10.1002/(SICI)1099-1263(199707)17:4<255::AID-JAT441>3.0.CO;2-D, 9285539.
25. Johnson EA, Svetlov SI, Wang KK, Hayes RL, Pineda JA. Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats. Exp Brain Res 2005, 167:17-26. 10.1007/s00221-005-2362-2, 16193270.
26. Filliat P, Baubichon D, Burckhart MF, Pernot-Marino I, Foquin A, Masqueliez C, Perrichon C, Carpentier P, Lallement G. Memory impairment after soman intoxication in rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics. Neurotoxicology 1999, 20:535-549.
27. Raffaele K, Hughey D, Wenk G, Olton D, Modrow H, McDonough J. Long-term behavioral changes in rats following organophosphonate exposure. Pharmacol Biochem Behav 1987, 27:407-412. 10.1016/0091-3057(87)90341-8, 3659063.
28. Yanagisawa N, Morita H, Nakajima T. Sarin experiences in Japan: acute toxicity and long-term effects. J Neurol Sci 2006, 249:76-85. 10.1016/j.jns.2006.06.007, 16962140.
29. Jones NC, Prior MJ, Burden-Teh E, Marsden CA, Morris PG, Murphy S. Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes. Eur J Neurosci 2005, 22:72-78. 10.1111/j.1460-9568.2005.04221.x, 16029197.
30. Ambrosini A, Louin G, Croci N, Plotkine M, Jafarian-Tehrani M. Characterization of a rat model to study acute neuroinflammation on histopathological, biochemical and functional outcomes. J Neurosci Methods 2005, 144:183-191.
31. Morganti-Kossmann MC, Rancan M, Otto VI, Stahel PF, Kossmann T. Role of cerebral inflammation after traumatic brain injury: a revisited concept. Shock 2001, 16:165-177. 10.1097/00024382-200116030-00001, 11531017.
32. Baille V, Dorandeu F, Carpentier P, Bizot JC, Filliat P, Four E, Denis J, Lallement G. Acute exposure to a low or mild dose of soman: biochemical, behavioral and histopathological effects. Pharmacol Biochem Behav 2001, 69:561-569. 10.1016/S0091-3057(01)00549-4, 11509217.
33. Viviani B, Bartesaghi S, Corsini E, Galli CL, Marinovich M. Cytokines role in neurodegenerative events. Toxicol Lett 2004, 149:85-89. 10.1016/j.toxlet.2003.12.022, 15093252.
34. Lopes KO, Sparks DL, Streit WJ. Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity. Glia 2008, 56:1048-1060. 10.1002/glia.20678, 18442088.
35. Simi A, Tsakiri N, Wang P, Rothwell NJ. Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans 2007, 35:1122-1126. 10.1042/BST0351122, 17956293.
36. Basu A, Krady JK, Levison SW. Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res 2004, 78:151-156. 10.1002/jnr.20266, 15378607.
37. Streit WJ, Braak H, Xue QS, Bechmann I. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol 2009, 118:475-485. 10.1007/s00401-009-0556-6, 2737117, 19513731.
38. Boutin H, LeFeuvre RA, Horai R, Asano M, Iwakura Y, Rothwell NJ. Role of IL-1alpha and IL-1beta in ischemic brain damage. J Neurosci 2001, 21:5528-5534.
39. Yamasaki Y, Matsuura N, Shozuhara H, Onodera H, Itoyama Y, Kogure K. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 1995, 26:676-680. discussion 681.
40. Zou JY, Crews FT. TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. Brain Res 2005, 1034:11-24. 10.1016/j.brainres.2004.11.014, 15713255.
41. Patel HC, Boutin H, Allan SM. Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration. Ann N Y Acad Sci 2003, 992:39-47. 10.1111/j.1749-6632.2003.tb03136.x, 12794045.
42. de Bock F, Dornand J, Rondouin G. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport 1996, 7:1125-1129. 10.1097/00001756-199604260-00004, 8817515.
43. Ali C, Nicole O, Docagne F, Lesne S, MacKenzie ET, Nouvelot A, Buisson A, Vivien D. Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. J Cereb Blood Flow Metab 2000, 20:956-966. 10.1097/00004647-200006000-00008, 10894179.
44. Eskes C, Honegger P, Juillerat-Jeanneret L, Monnet-Tschudi F. Microglial reaction induced by noncytotoxic methylmercury treatment leads to neuroprotection via interactions with astrocytes and IL-6 release. Glia 2002, 37:43-52. 10.1002/glia.10019, 11746782.
45. Penkowa M, Giralt M, Lago N, Camats J, Carrasco J, Hernandez J, Molinero A, Campbell IL, Hidalgo J. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol 2003, 181:130-148. 10.1016/S0014-4886(02)00051-1, 12781987.
46. Loddick SA, Turnbull AV, Rothwell NJ. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1998, 18:176-179. 10.1097/00004647-199802000-00008, 9469160.
47. Kan RK, Fath DM, Tompkins CP, Hamilton TA. Systematic characterization of regional and temporal brain injury following status epilepticus induced by chemical warfare nerve agent soman. Society for Neuroscience annual meeting 2008, San Diego, CA. Neuroscience Meeting Planner.
48. Penkowa M, Moos T, Carrasco J, Hadberg H, Molinero A, Bluethmann H, Hidalgo J. Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice. Glia 1999, 25:343-357. 10.1002/(SICI)1098-1136(19990215)25:4<343::AID-GLIA4>3.0.CO;2-V, 10028917.
49. Juric DM, Carman-Krzan M. Cytokine-regulated secretion of nerve growth factor from cultured rat neonatal astrocytes. Pflugers Arch 2000, 440:R96-98. 10.1007/s004240000020, 11005627.
50. Naitoh Y, Fukata J, Tominaga T, Nakai Y, Tamai S, Mori K, Imura H. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun 1988, 155:1459-1463. 10.1016/S0006-291X(88)81305-6, 2845968.