Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus

Brain Research

Volumn 843, Issue 1-2, 1999, Pages 118-129

  Baik, Eun Joo ^a   Kim, Eun Joo ^a   Lee, Soo Hwan ^a   Moon, Chang Hyun ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Cyclooxygenase 2 inhibitor; Hippocampus; Kainic acid induced seizure; Prostaglandin; TUNEL positive neuronal death

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; KAINIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SEIZURE;

ANIMALS; ASPIRIN; CELL DEATH; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG SYNERGISM; HIPPOCAMPUS; INDOMETHACIN; ISOENZYMES; KAINIC ACID; MALE; MICE; NEURONS; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SEIZURES; SULFONAMIDES; TIME FACTORS;

EID: 0007414682     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01797-7     Document Type: Article

References (35)

1. Adams J., Collaco-Moraes Y., Belleroche J.D. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J. Neurochem. 66:1996;6-13.
2. 2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res. 14:1994;237-243.
3. 2. Epilepsy Res. 30:1998;63-68.
4. Baran H., Vass K., Lassman H., Hornykiewicz O. The cyclooxygenase-2 and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity. Brain Res. 646:1994;201-206.
5. Baran H., Heldt R., Hertting G. Increased prostaglandin formation in rat brain following systemic application of kainic acid. Brain Res. 404:1987;107-112.
6. Chen Q., Olney J.W., Lukasiewicz P.D., Almli T., Romana C. Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina. Neuroscience Letters. 242:1998;163-166.
7. Chen J., Marsh T., Zhang J.S., Graham S.H. Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. NeuroReport. 6:1995;245-248.
8. 2 against the toxic effects of actinomycin C on embryonic neural retina cells. Prostaglandins. 44:1992;129-134.
9. Ehrlich K., Plate S., Stroff T., Gretzer B., Respondondek M., Peskar B.M. Peptidergic and cholinergic neurons and mediators in peptone-induced gastroprotection: role of cycloocygenase-2. Am. J. Physiol. 274:1998;955-964.
10. Förstermann U., Heldt R., Knappen F., Hertting G. Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain. Brain Res. 240:1982;303-310.
11. Y. Gavrieli, Y. Sherman, S.A. Ben-Sasson, Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, 119 (1992) 493-501.
12. Hay C., Belleroche J.D. Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord. NeuroReport. 8:1997;1249-1251.
13. Hirata H., Cadet J.L. Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice. Mol. Brain Res. 48:1997;145-148.
14. Hirata T., Ukawa H., Yamakuni H., Kato S., Takeuchi K. Cyclo-oxygenase isozymes in mucosal ulcerogenic and functional response following barrier disruption in rat stomachs. Br. J. Pharmacol. 122:1997;447-454.
15. Ichihara A., Imig J.D., Inscho E.W., Navar L.G. Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS. Am. J. Physiol. 275:1998;605-612.
16. Kaufmann W.E., Worley P.F., Pegg J., Bremer M., Isakson P. Cyclooxygenase-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2317-2321.
17. Kondo F., Kondo Y., Gomez-Vargas M., Ogawa N. Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gerbils. Brain Res. 791:1998;352-356.
18. Kondo T., Sharp F.R., Honkaniemi J., Mikawa S., Epstein C.J., Chan P.H. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 17:1997;241-256.
19. Li D.Y., Hardy P., Abran D., Martines-Bermudez A.K., Guerguerian A.M., Bhattacharya M., Almazan G., Menezes R., Peri K.G., Varma D.R., Chemtob S. Key role for cyclooxygenase-2 in PGE2 and PGF2alpha receptor regulation and cerebral blood flow of the newborn. Am. J. Physiol. 273:1997;1283-1290.
20. Marcheselli V.L., Bazan N.G. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Biological Chemistry. 271:1996;24794-24799.
21. Miettinen S., Fusco F.R., Yrjanheikki J., Keinanen R., Hirvonen T., Roivainen R., Narhi M., Hokfelt T., Koistinaho J. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. Proc. Natl. Acad. Sci. 94:1997;6500-6505.
22. Mikuni M., Pall M., Peterson C.M., Peterson C.A., Hellberg P., Brannstrom M., Richards J.S., Hedin L. The selective prostaglandin endoperoxidase synthase-2 inhibitor, NS-398, reduces prostaglandin production and ovulation in vivo and in vitro in the rat. Biol. Reprod. 59:1998;1077-1083.
23. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. 95:1998;10954-10959.
24. Nogawa S., Zhand F., Ross M.E., Ladecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17:1997;2746-2755.
25. Paoletti A.M., Piccirilli S., Costa N., Rotiroti D., Bagetta G., Nistico G. Systemic administration of N-nitro-L-arginine methyl ester and indomethacin reduced the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by licl and tacrine in rat. Exp. Neurol. 149:1998;349-355.
26. Peterson C.L., Thompson M.A., Martin D., Nadler V. Modulation of glutamate aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism. J. Neurochem. 64:1995;1152-1160.
27. Reder A.T., Thapar M., Sapugay A.M., Jensen M.A. Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. J. Neuroimmunol. 54:1994;117-127.
28. Sairanen T., Ristimaki A., Karjalainen-Lindsberg M.L., Paetau A., Kaste M., Lindsberg P.J. Cyclooxygenase-2 is induced globally in infarcted human brain. Ann. Neurol. 43:1998;738-747.
29. Seregi A., Forstermann U., Hertting G. Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. Brain Res. 305:1984;393-395.
30. Shitashige M., Morita I., Murota S. Different substrate utilization between prostaglandin endoperoxide H synthase-1 and -2 in NIH3T fibroblasts. Biochim. Biophys. Acta. 1389:1998;57-66.
31. Sperk G., Lassmann H., Baran H., Seitelberger F., Horneykiewicz O. Kainic acid-induced seizure: dose-relationship of behavioural, neurochemical and histopathological changes. Brain Res. 338:1985;289-295.
32. Tanaka K., Graham S.H., Simon R.P. The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. Brain Res. 737:1996;59-63.
33. Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Exp. Neurol. 144:1997;339-349.
34. Tsujii M., DuBois R.N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83:1995;493-501.
35. Walton M., Sirimanne E., Williams C., Gluckman P.D., Keelan J., Mitchell M.D., Dragunow M. Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival? Mol. Brain Res. 50:1997;165-170.