Functions of zinc in signaling, proliferation and differentiation of mammalian cells

BioMetals

Volumn 14, Issue 3-4, 2001, Pages 331-341

  Beyersmann, Detmar ^a   Haase, Hajo ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

Differentiation; Metallothionein; Proliferation; Signal transduction; Zinc

Indexed keywords

CALCIUM ION; CARRIER PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP; CYCLIC NUCLEOTIDE; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MTF 1; UNCLASSIFIED DRUG; ZINC ION; ZINC TRANSPORTER 1;

APOPTOSIS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DNA SYNTHESIS; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; MAMMAL CELL; MITOSIS; NONHUMAN; NUCLEOTIDE METABOLISM; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL DIVISION; CYCLIC AMP; CYCLIC GMP; HUMANS; METALLOTHIONEIN; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTEIN KINASE C; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; ZINC;

EUKARYOTA; MAMMALIA;

EID: 0035696301     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012905406548     Document Type: Review

References (88)

1. Regulation of the ontogeny of rat liver metallothionein mRNA by zinc
2. Metallothionein and apoptosis during differentiation of myoblasts to myotubes: Protection against free radical toxicity
3. Delay of M-phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3L1 fibroblasts
4. Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts
5. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels
6. 19F-NMR spectroscopy
7. The galvanization of biology: A growing appreciation for the roles of zinc
8. A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer
9. The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
10. Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from northern China
11. Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger
12. Measurement of intracellular free zinc in living neurons
13. 2+ requirement for DNA synthesis by 3T3 cells
14. 2+ for the induction of thymidine kinase but not ornithine decarboxylase in 3T3 cells stimulated from quiescence
15. 2+
16. Decline in somatomedin-C, insulin-like growth factor-1 with experimentally induced zinc deficiency in human subjects
17. Measurement of zinc in hepatocytes by using a fluorescent probe, Zinquin: Relationship to metallothionein and intracellular zinc
18. Zinc increases the affinity of phorbol ester receptor in T lymphocytes
19. Zinc can increase the activity of protein kinase C and contributes to its binding to the plasma membrane in T lymphocytes
20. Zinc metabolism in the brain: Relevance to human neurodegenerative disorders
21. Effects of zinc chloride on the hydrolysis of cyclic GMP and cyclic AMP by the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart
22. Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies
23. Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites
24. Interaction between protein kinase C and regulatory ligand is enhanced by a chelatable pool of cellular zinc
25. Zinc interactions and conserved motifs of the cGMP-binding cGMP specific phosphodiesterase suggest that it is a zinc hydrolase
26. 4A) and DNA synthesis
27. Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent probes and atomic absorption
28. Dynamic changes in intracellular location of metallothionein in rat keratinocytes after ultraviolet-B irradiation
29. Extracellular zinc ions induce mitogen-activated protein kinase activity and protein tyrosine phosphorylation in bombesin-sensitive Swiss 3T3 fibroblasts
30. The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold
31. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6αβ
32. Effect of dietary zinc deficiency on protein synthesis in cell-free systems isolated from rat liver
33. Solution structure of a cysteine rich domain of rat protein kinase C
34. Extracellular calcium stimulates DNA synthesis in synergism with zinc, insulin and insulin-like growth factor 1 in fibroblasts
35. Identification and characterization of zinc binding sites in protein kinase C
36. QM is a novel zinc-binding transcriptional regulatory protein: Its binding to c-jun is regulated by zinc ions and phosphorylation by protein kinase C
37. Control of zinc transfer between thionein, metallothionein, and zinc proteins
38. Pyrithione, a zinc ionophore, inhibits NF-κB activation
39. Extracellular zinc activates p70S6 kinase through the phosphatidylinositol 3-kinase signaling pathway
40. Superoxide-induced stimulation of protein kinase C via thiol modification and modulation of zinc content
41. Recombinant expression of a Type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants
42. Subcellular localization of metallothionein IIA in human bladder tumor cells using a novel epitope-specific antiserum
43. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene
44. Inhibition of insulin-like growth factor-1 mitogenic action by zinc chelation is associated with a decreased mitogen-activated protein kinase activation in RAT 1 fibroblasts
45. Modulation of the phosphorylation and activity of calcium/calmodulin-dependent protein kinase II by zinc
46. The role of zinc in growth and cell proliferation
47. Coordination dynamics of biological zinc 'clusters' in metallothioneins and in the DNA binding domain of the transcription factor Ga14
48. Inhibitory sites in enzymes: Zinc removal and reactivation by thionein
49. Multivalent cations and ligand affinity of the type 1 insulin-like growth factor receptor on P2A2-LISN muscle cells
50. The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic insulin-like growth factor 1 and growth hormone receptor genes
51. 2+ mobilization in hepatocytes
52. Cell cycle regulation of metallothionein in human colon cancer cells
53. Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development
54. Immunohistochemical localization of metallothionein in human thyroid tumors
55. Divalent metal cation requirement and possible classification of cGMP-inhibited phosphodiesterase as a metallohydrolase
56. Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence
57. Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development
58. Induction of an immediate early gene egr-1 by zinc through extracellular signal-related kinase activation in cortical culture: Its role in zinc-induced neuronal death
59. The complete primary structure of protein kinase C - The major phorbol ester receptor
60. Zinc dependent activation of cAMP-specific phosphodiesterase (PDE4A)
61. Inhibition of myoblast differentiation by lack of zinc
62. Detection of secretion from single pancreatic β-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy
63. The regulatory domain of protein kinase C coordinates four atoms of zinc
64. Influence of alimentary zinc deficiency on the concentration of growth hormone (GH), insulin-like growth factor 1 (IGF-I) and insulin in the serum of force-fed rats
65. Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells
66. Activation of MAPKs in human bronchial epithelial cells exposed to metals
67. Transient peaks in zinc and metallothionein levels during differentiation of 3T3L1 cells
68. Measurement of intracellular free zinc in living cortical neurons: Routes of entry
69. Intracellular free zinc and zinc buffering in human red blood cells
70. Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1
71. Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupole relaxation studies of the role of bound zinc
72. Zinc reversibly inhibits steroid binding to murine glucocorticoid receptor
73. Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation
74. Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes
75. Induction and subcellular localization of metallothionein in regenerating rat liver
76. Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein
77. The biochemical basis of zinc physiology
78. 2+ increase the cyclic GMP level in PC 12 cells by inhibition of the cyclic nucleotide phosphodiesterase
79. 2+
80. Nucleocytoplasmic functionality of metallothionein
81. The structure of the zinc sites of Escherichia coli DNA-dependent RNA polymerase
82. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals
83. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
84. Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy) acetic acid], a new specific fluorescent probe for Zn(II)
85. Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton
86. Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1