Mechanisms of mammalian zinc-regulated gene expression

Biochemical Society Transactions

Volumn 36, Issue 6, 2008, Pages 1262-1266

  Jackson, Kelly A ^a   Valentine, Ruth A ^a   Coneyworth, Lisa J ^a   Mathers, John C ^a   Ford, Dianne ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Metal response element binding transcription factor 1 (MTF1); mRNA stability; Solute carrier 30A5 gene (SLC30A5); Transcription; Zinc; Zinc transporter 5 (ZnT5)

Indexed keywords

GENE PRODUCT; MESSENGER RNA; METAL RESPONSE ELEMENT BINDING TRANSCRIPTION FACTOR 1; SOLUBLE CARRIER 30A5; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC ION; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; SLC30A5 PROTEIN, HUMAN; ZINC;

ALZHEIMER DISEASE; ARTICLE; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; MAMMAL CELL; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RNA STABILITY; UPREGULATION; ANIMAL; DRUG EFFECT; GENETICS; MAMMAL; REVIEW;

MAMMALIA;

ANIMALS; CATION TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MAMMALS; RNA STABILITY; TRANSCRIPTION, GENETIC; ZINC;

EID: 59149085523     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0361262     Document Type: Article

References (47)

1. Andreini, C., Banci, L., Bertini, I. and Rosato, A. (2006) Counting the zinc-proteins encoded in the human genome. J. Proteome Res. 5, 196-201
2. Scott, L.J., Mohlke, K.L., Bonnycastle, L.L., Willer, C.J., Li, Y., Duren, W.L., Erdos, M.R., Stringham, H.M., Chines, P.S., Jackson, A.U. et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341-1345
3. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S. et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885
4. Zeggini, E., Weedon, M.N., Lindgren, C.M., Frayling, T.M., Elliott, K.S., Lango, H., Timpson, N.J., Perry, J.R., Rayner, N.W., Freathy, R.M. et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341
5. Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G.B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S. et al. (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat. Genet. 39, 770-775
6. Staiger, H., Machicao, F., Stefan, N., Tschritter, O., Thamer, C., Kantartzis, K., Schafer, S.A., Kirchhoff, K., Fritsche, A. and Haring, H.U. (2007) Polymorphisms within novel risk loci for type 2 diabetes determine β-cell function. PLoS ONE 2, e832
7. Religa, D., Strozyk, D., Cherny, R.A., Volitakis, I., Haroutunian, V., Winblad, B., Naslund, J. and Bush, A.I. (2006) Elevated cortical zinc in Alzheimer disease. Neurology 67, 69-75
8. Crouch, P.J., White, A.R. and Bush, A.I. (2007) The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease. FEBS J. 274, 3775-3783
9. Stoltenberg, M., Bush, A.I., Bach, G., Smidt, K., Larsen, A., Rungby, J., Lund, S., Doering, P. and Danscher, G. (2007) Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency. Neuroscience 150, 357-369
10. Franklin, R.B., Feng, P., Milon, B., Desouki, M.M., Singh, K.K., Kajdacsy-Balla, A., Bagasra, O. and Costello, L.C. (2005) hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol. Cancer 4, 32
11. Taylor, K.M., Morgan, H.E., Smart, K., Zahari, N.M., Pumford, S., Ellis, I.O., Robertson, J.F. and Nicholson, R.I. (2007) The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer. Mol. Med. 13, 396-406
12. Beck, F.W., Li, Y., Bao, B., Prasad, A.S. and Sarkar, F.H. (2006) Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line. Nutrition 22, 1045-1056
13. Blanchard, R.K., Moore, J.B., Green, C.L. and Cousins, R.J. (2001) Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc. Natl. Acad. Sci. U.S.A. 98, 13507-13513
14. Cousins, R.J., Blanchard, R.K., Popp, M.P., Liu, L., Cao, J., Moore, J.B. and Green, C.L. (2003) A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc. Natl. Acad. Sci. U.S.A. 100, 6952-6957
15. Kindermann, B., Doring, F., Fuchs, D., Pfaffi, M.W. and Daniel, H. (2005) Effects of increased cellular zinc levels on gene and protein expression in HT-29 cells. Biometals 18, 243-253
16. Kindermann, B., Doring, F., Pfaffi, M. and Daniel, H. (2004) Identification of genes responsive to intracellular zinc depletion in the human colon adenocarcinoma cell line HT-29. J. Nutr. 134, 57-62
17. Moore, J.B., Blanchard, R.K., McCormack, W.T. and Cousins, R.J. (2001) cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. J. Nutr. 131, 3189-3196
18. Pfaffi, M.W., Gerstmayer, B., Bosio, A. and Windisch, W. (2003) Effect of zinc deficiency on the mRNA expression pattern in liver and jejunum of adult rats: monitoring gene expression using cDNA microarrays combined with real-time RT-PCR. J. Nutr. Biochem. 14, 691-702
19. tom Dieck, H., Doring, F., Fuchs, D., Roth, H.P. and Daniel, H. (2005) Transcriptome and proteome analysis identifies the pathways that increase hepatic lipid accumulation in zinc-deficient rats. J. Nutr. 135, 199-205
20. tom Dieck, H., Doring, F., Roth, H.P. and Daniel, H. (2003) Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays. J. Nutr. 133, 1004-1010
21. Yamada, H., Suzuki, K. and Koizumi, S. (2007) Gene expression profile in human cells exposed to zinc. J. Toxicol. Sci. 32, 193-196
22. Lyons, T.J., Gasch, A.P., Gaither, L.A., Botstein, D., Brown, P.O. and Eide, D.J. (2000) Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proc. Natl. Acad. Sci. U.S.A. 97, 7957-7962
23. Zhao, H. and Eide, D.J. (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 17, 5044-5052
24. MacDiarmid, C.W., Gaither, L.A. and Eide, D. (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J. 19, 2845-2855
25. Busenlehner, L.S., Pennella, M.A. and Giedroc, D.P. (2003) The SmtB/ArsR family of metalloregulatory transcriptional repressors: structural insights into prokaryotic metal resistance. FEMS Microbiol. Rev. 27, 131-143
26. Patzer, S.I. and Hantke, K. (2000) The zinc-responsive regulator Zur and its control of the znu gene cluster encoding the ZnuABC zinc uptake system in Escherichia coli. J. Biol. Chem. 275, 24321-24332
27. Heuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M. and Schaffner, W. (1994) The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13, 2870-2875
28. Langmade, S.J., Ravindra, R., Daniels, P.J. and Andrews, G.K. (2000) The transcription factor MTF-1 mediates metal regulation of the mouse Znt1 gene. J. Biol. Chem. 275, 34803-34809
29. Laity, J.H. and Andrews, G.K. (2007) Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Arch. Biochem. Biophys. 463, 201-210
30. Ford, D. (2004) Intestinal and placental zinc transport pathways. Proc. Nutr. Soc. 63, 21-29
31. Cragg, R.A., Christie, G.R., Phillips, S.R., Russi, R.M., Kury, S., Mathers, J.C., Taylor, P.M. and Ford, D. (2002) A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J. Biol. Chem. 277, 22789-22797
32. Liuzzi, J.P., Blanchard, R.K. and Cousins, R.J. (2001) Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J. Nutr. 131, 46-52
33. Liuzzi, J.P., Bobo, J.A., Lichten, L.A., Samuelson, D.A. and Cousins, R.J. (2004) Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Proc. Natl. Acad. Sci. U.S.A. 101, 14355-14360
34. Pfaffi, M.W. and Windisch, W. (2003) Influence of zinc deficiency on the mRNA expression of zinc transporters in adult rats. J. Trace Elem. Med. Biol. 17, 97-106
35. Bird, A.J., Blankman, E., Stillman, D.J., Eide, D.J. and Winge, D.R. (2004) The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2. EMBO J. 23, 1123-1132
36. Bird, A.J., Gordon, M., Eide, D.J. and Winge, D.R. (2006) Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts. EMBO J. 25, 5726-5734
37. Wimmer, U., Wang, Y., Georgiev, O. and Schaffner, W. (2005) Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res. 33, 5715-5727
38. Zheng, D., Feeney, G.P., Kille, P. and Hogstrand, C. (2008) Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. Physiol. Genomics 34, 205-214
39. Jackson, K.A., Helston, R.M., McKay, J.A., O'Neill, E.D., Mathers, J.C. and Ford, D. (2007) Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localised and regulated by zinc through transcription and mRNA stability. J. Biol. Chem. 282, 10423-10431
40. Weaver, B.P., Dufner-Beattie, J., Kambe, T. and Andrews, G.K. (2007) Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). Biol. Chem. 388, 1301-1312
41. Rouault, T.A. (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2, 406-414
42. Kambe, T., Narita, H., Yamaguchi-Iwai, Y., Hirose, J., Amano, T., Sugiura, N., Sasaki, R., Mori, K., Iwanaga, T. and Nagao, M. (2002) Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic β cells. J. Biol. Chem. 277, 19049-19055
43. Ishihara, K., Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y. and Kambe, T. (2006) Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. J. Biol. Chem. 281, 17743-17750
44. Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y. and Kambe, T. (2005) Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. J. Biol. Chem. 280, 637-643
45. Valentine, R.A., Jackson, K.A., Christie, G.R., Mathers, J.C., Taylor, P.M. and Ford, D. (2007) ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. J. Biol. Chem. 282, 14389-14393
46. Cragg, R.A., Phillips, S.R., Piper, J.M., Varma, J.S., Campbell, F.C., Mathers, J.C. and Ford, D. (2005) Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation. Gut 54, 469-478
47. Helston, R.M., Phillips, S.R., McKay, J.A., Jackson, K.A., Mathers, J.C. and Ford, D. (2006) Zinc transporters in the mouse placenta show a coordinated regulatory response to changes in dietary zinc intake. Placenta 28, 437-444