The CFTR chloride channel: Nucleotide interactions and temperature-dependent gating

Journal of Membrane Biology

Volumn 163, Issue 1, 1998, Pages 55-66

  Mathews, C J ^a   Tabcharani, J A ^a   Hanrahan, J W ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Anion channel; Cystic fibrosis; Nucleotide binding; Patch clamp; Temperature coefficient

Indexed keywords

ADENYLYLIMIDODIPHOSPHATE; CHLORIDE CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; NUCLEOTIDE; PROTEIN KINASE C; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; CYSTIC FIBROSIS; ION CONDUCTANCE; NONHUMAN; PHOSPHORYLATION; TEMPERATURE DEPENDENCE;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ION CHANNEL GATING; TEMPERATURE;

ANIMALIA;

EID: 0032079760     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002329900370     Document Type: Article

References (45)

1. 2+ channels in chick sensory neurones. Eur. Biophys. J. 23:189-195
2. Anderson, M.P., Berger, H.A., Rich, D.P., Gregory, R.J., Smith, A.E., Welsh, M.J. 1991. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67:775-784
3. - channel gating to an ATP hydrolysis cycle. Neuron 12:473-482
4. - channel by specific protein kinases and phosphatases. J. Biol. Chem. 268:2037-2047
5. Bukauskas, F.F., Elfgang, C., Willecke, K., Weingart, R. 1995. Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. Biophys. J. 68:2289-2298
6. Carson, M.R., Travis, S.M., Welsh, M.J. 1995. The two nucleotide-binding domains of CFTR have distinct functions in controlling channel activity. J. Biol. Chem. 270:1711-1717
7. Carson, M.R., Welsh, M.J. 1995. Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteins. Biophys. J. 69:2443-2448
8. Chang, X.-B., Tabcharani, J.A., Hou, Y.-X., Jensen, T.J., Kartner, N., Alon, N., Hanrahan, J.W., Riordan, J.R. 1993. Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all ten PKA consensus phosphorylation sites. J. Biol. Chem. 268:11304-11311
9. Cheng, S.H., Rich, D.P., Marshall, J., Gregory, R.J., Welsh, M.J., Smith, A.E. 1991. Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell 66:1027-1036
10. - channel opening and closing rates, confirming hydrolysis of two ATP molecules per gating cycle. Biophys. J. 70:A127(Abstr.)
11. Fischer, H., Machen, T.E. 1994. CFTR displays voltage dependence and two gating modes during stimulation. J. Gen. Physiol. 104:541-566
12. +-ATPase pump currents in giant excised patches activated by an ATP concentration jump. Biophys. J. 71:2486-2500
13. Gadsby, D.C., Nagel, G., Hwang, T.-C. 1995. The CFTR chloride channel of mammalian heart. Annu. Rev. Physiol. 57:387-416
14. Gray, M.A., Greenwell, J.R., Argent, B.E. 1988. Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J. Membrane Biol. 105:131-142
15. Gunderson, K.L., Kopito, R.R. 1994. Effects of pyrophosphate and nucleotide analogues suggests a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating. J. Biol. Chem. 269:19349-19353
16. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, F.J. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391:85-100
17. Hanrahan, J.W., Tabcharani, J.A., Becq, F., Mathews, C.J., Augustinas, O., Jensen T.J., Chang, X.-B., Riordan, J.R. 1995. Function and dysfunction of the CFTR chloride channel. In: Ion Channels and Genetic Diseases. D.C. Dawson and R. A. Frizzell, editors, pp. 125-137. New York: Rockefeller Univ. Press
18. Hanrahan, J.W., Kon, Z., Mathews, C.J., Luo, J., Jia, Y., Linsdell, P. 1998. Patch clamp studies of the CFTR chloride channel. Meths. Enz. (in press)
19. + channels in a physiological environment near 37°C. J. Membrane Biol. 146:85-90.
20. Hille, B. 1992. Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA
21. Hwang, T-C., Nagel, G., Nairn, A.C., Gadsby, D.C. 1994. Regulation of the gating of cystic fibrosis transmembrane conductance regulator Cl channels by phosphorylation and ATP hydrolysis. Proc. Natl. Acad. Sci. USA 91:4698-4702
22. Hyde, S.C., Emsley, P., Hartshorn, M.J., Mimmack, M.M., Gileadi, U., Pearce, S.R., Gallagher, M.P., Gill, D.R., Hubbard, R.E., Higgins, C.F. 1990. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346:362-365
23. Jia, Y., Mathews, C.J., Hanrahan, J.W. 1997. Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. J. Biol. Chem. 272:4978-4984
24. Li, C., Ramjeesingh, M., Wang, W., Garami, E., Hewryk, M., Lee, D., Rommens, J.M., Galley, K., Bear, C.E. 1996. ATPase activity of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 271:28463-28468
25. Manavalan, P., Dearborn, D.G., McPherson, J.M., Smith, A.E. 1995. Sequence homologies between nucleotide binding regions of CFTR and G-proteins suggest structural and functional similarities. FEBS Lett. 366:87-91
26. Mathews, C.J., Tabcharani, J.A., Chang, X.-B., Riordan, J.R., Hanrahan, J.W. 1995. Models for gating of CFTR chloride channels. Ped. Pulmonol. 20:424(Abstr.)
27. Mathews, C.J., Tabcharani, J.A., Chang, X.-B., Riordan, J.R., Hanrahan, J.W. 1996. Characterization of nucleotide interactions with CFTR channels. Ped. Pulmonol. Suppl. 13:221(Abstr.)
28. Mathews, C.J., Tabcharani, J.A., Chang, X.-B., Riordan, J.R., Hanrahan, J.W. 1998. Phosphorylation-dependent gating of CFTR by nucleotides. J. Physiol. (in press)
29. Mejillano, M.R., Shivanna, B.D., Himes, R.H. 1996. Studies on the nocodazole-induced GTPase activity of tubulin. Arch. Biochem. Biophys. 336:130-138
30. Nagel, G., Hwang, T-C., Nairn, A.C., Gadsby, D.C. 1994. AMP-PNP delays the closing of CFTR Cl channels opened by ATP. Biophys. J. 66:A141(Abstr.)
31. Nagy, K., Kiss, T., Hof, D. 1983. Single Na channels in mouse neuroblastoma cell membrane. Pfluegers Arch. 399:302-308
32. B responses using patch-clamp recordings in rat hippocampal slices. J. Physiol. 463:391-407
33. Picciotto, M.R., Cohn, J.A., Bertuzzi, G., Greengard, P., Nairn, A.C. 1992. Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 267:12742-12752
34. Pusch, M., Ludewig, U., Jentsch, T.J. 1997. Temperature dependence of fast and slow gating relaxations of C1C-0 chloride channels. J. Gen. Physiol. 109:105-116
35. Reddy, M.M., Quinton, P.M. 1994. Rapid regulation of electrolyte absorption in sweat duct. J. Membrane Biol. 140:57-67
36. Riordan, J.R., Rommens, J.M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., Drumm, M.L., Iannuzzi, M.C., Collins, F.S., Tsui, L.-C. 1989. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA. Science 245:1066-1073
37. - channel gating by ADP and ATP analogues. J. Gen. Physiol. 105:329-361
38. Schwarz, J.R., Eikhof, G. 1987. Na currents and action potentials in rat myelinated nerve fibres at 20 and 37°C. Pfluegers Arch. 409:569-577
39. Siemankowski, R.F., Wiseman, M.O., White, H.D. 1985. ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle. Proc. Natl. Acad. Sci. USA 82:658-662
40. - channel in CHO cells stably expressing the cystic fibrosis gene. Nature 352:628-631
41. 84. FEBS Lett. 270:157-164
42. +-ATPase. Arch. Biochem. Biophys. 266:289-297
43. Venglarik, C.J., Schultz, B.D., Frizzell, R.A., Bridges, R.J. 1994. ATP alters current fluctuations of cystic fibrosis transmembrane conductance regulator: Evidence for a three-state activation mechanism. J. Gen. Physiol. 104:123-146
44. 0-ATP synthase: development of direct optical probes of the catalytic mechanism. Biochim. Biophys. Acta 1275:101-104
45. Welsh, M.J., Smith, A.E. 1994. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73:1251-1254