Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 22, 2008, Pages 5847-5850

  Slaymaker, Ian M ^a   Bracey, Michael ^a   Mileni, Mauro ^a   Garfunkle, Joie ^a   Cravatt, Benjamin F ^a   Boger, Dale L ^a   Stevens, Raymond C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Binding affinity; Fatty acid amide hydrolase; Stability

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; FLUORINE DERIVATIVE; MEMBRANE PROTEIN; OL 135; PYRIDINE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ARTICLE; BINDING AFFINITY; CORRELATION ANALYSIS; CRYSTALLIZATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME STABILITY; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; MEASUREMENT; MELTING POINT; NONHUMAN; PH; THERMOSTABILITY;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANIMALS; DRUG DESIGN; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; OXAZOLES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55249085376     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.086     Document Type: Article

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