The exploration of thienothiazines as selective butyrylcholinesterase inhibitors

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 1, 2012, Pages 190-205

  Karlsson, Daniela ^a   Fallarero, Adyary ^a   Brunhofer, Gerda ^a,b   Mayer, Claudia ^b   Prakash, Ohm ^c   Mohan, C Gopi ^c   Vuorela, Pia ^a   Erker, Thomas ^b  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b UNIVERSITY OF VIENNA   (Austria)

^c AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; ChemGPS NP; Cytotoxicity; Inhibition; Thienothiazine

Indexed keywords

1 [N [2 (3,4 DIMETHOXYPHENYL)ETHYL] N METHYLAMINOACETYL] 6 ETHYL 2,3 DIHYDRO 3 (4 METHOXYBENZYLIDENE) 1H THIENO[2,3 B][1,4]THIAZINE; 1 CHLOROACETYL 6 ETHYL 2,3 DIHYDRO 3 (4 METHOXYBENZYLIDENE) 1H THIENO[2,3 B][1,4]THIAZINE; 3 BENZYL 1 [N [2 (3,4 DIMETHOXYPHENYL)ETHYL] N METHYLAMINOACETYL] 6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZINE; 3 BENZYL 1 CHLOROACETYL 6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZINE; 3 BENZYL 6 ETHYL 1H THIENO[2,3 B][1,4]THIAZIN 2(3H) ONE; 3 BENZYL 6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZINE; 6 ACETYL 3 BENZYL 1H THIENO[2,3 B][1,4]THIAZIN 2(3H) ONE; 6 ETHYL 1 METHYL 1H THIENO[2,3 B][1,4]THIAZINE 2(3H) THIONE; 6 ETHYL 2,3 DIHYDRO 3 (4 METHOXYBENZYLIDENE) 1H THIENO[2,3 B][1,4]THIAZINE; 6 ETHYL 3 (4 METHOXYBENZYLIDENE) 1H THIENO[2,3 B][1,4]THIAZIN 2(3H) ONE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ETHYL 2,3 DIHYDRO 2 THIOXO 1H THIENO[2,3 B][1,4]THIAZINE 6 CARBOXYLATE; HYDROLASE; THIAZINE DERIVATIVE; THIENOTHIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR PROBE; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ALZHEIMER DISEASE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CACO-2 CELLS; CELL LINE; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; FOLLOW-UP STUDIES; HEP G2 CELLS; HUMANS; MICE; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 84862733911     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.05.014     Document Type: Article

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