Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. Part 30: Synthesis and pharmacological properties of thieno[2,3-b][1,4]thiazines with potential vasopressin receptor antagonistic activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 3, 2006, Pages 826-836

  Galanski, Maria E ^a   Erker, Thomas ^a   Handler, Norbert ^a   Lemmens Gruber, Rosa ^a   Kamyar, Majidreza ^a   Studenik, Christian R ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Guinea pigs; Papillary muscles; Right atria; Terminal ilea; Thieno 2,3 b 1,4 thiazines; Vascular smooth muscles; Vasopressin receptor antagonistic activity

Indexed keywords

N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2 METHYLBENZAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2 PHENYLACETAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2,3 DIMETHYLBENZAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2,5 DIMETHYLBENZAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 3 METHYL 2 THIOPHENECARBOXAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 4 FLUOROBENZAMIDE; N1 [4 [(6 BENZYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 5 CHLORO 2 THIOPHENECARBOXAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2 METHYLBENZAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2 PHENYLACETAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2,3 DIMETHYLBENZAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 2,5 DIMETHYLBENZAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 3 METHYL 2 THIOPHENECARBOXAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 4 FLUOROBENZAMIDE; N1 [4 [(6 ETHYL 2,3 DIHYDRO 1H THIENO[2,3 B][1,4]THIAZIN 1 YL)CARBONYL]PHENYL] 5 CHLORO 2 THIOPHENECARBOXAMIDE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; GUINEA PIG; HEART; HEART PAPILLARY MUSCLE; ILEUM; MUSCLE RELAXATION; NONHUMAN; SMOOTH MUSCLE; STATISTICAL SIGNIFICANCE;

ANIMALS; AORTA; ARGININE VASOPRESSIN; BICYCLO COMPOUNDS, HETEROCYCLIC; FEMALE; GUINEA PIGS; HEART ATRIA; ILEUM; MALE; MUSCLE RELAXATION; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PULMONARY ARTERY; RECEPTORS, VASOPRESSIN; THIAZINES; VASODILATION;

ANIMALIA; CAVIA; CAVIA PORCELLUS;

EID: 28844486754     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.001     Document Type: Article

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