Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 2, 2011, Pages 763-770

  Luo, Wen ^a   Li, Yan Ping ^a   He, Yan ^a   Huang, Shi Liang ^a   Tan, Jia Heng ^a   Ou, Tian Miao ^a   Li, Ding ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Acetylcholinesterase; Anti Alzheimer agent; Butyrylcholinesterase; Self induced A aggregation; Tacrine hybrids

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; ACETYLCHOLINESTERASE; ALKOXYBENZENE DERIVATIVE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CURCUMIN; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 4 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)BUTANE 1,4 DIAMINE; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 5 (1,2,4 TETRAHYDROACRIDIN 9 YL)PENTANE 1,5 DIAMINE; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)HEXANE 1,6 DIAMINE; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 7 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)HEPTANE 1,7 DIAMINE; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)OCTANE 1,8 DIAMINE; N 1 ((7 METHXYBENZO[D][1,3]DIOXOL 5 YL)METHYL) N 9 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)NONANE 1,9 DIAMINE; N 1 (1,2,3,4 TETRAHYDROACRIDIN 9 YL) N 6 (3,4,5 TRIMETHOXYBENZYL)HEXANE 1,6 DIAMINE; N 1 (1,2,3,4 TETRAHYDROACRIDIN 9 YL) N 7 (3,4,5 TRIMETHOXYBENZYL)HEPTANE 1,7 DIAMINE; N 1 (1,2,3,4 TETRAHYDROACRIDIN 9 YL) N 8 (3,4,5 TRIMETHOXYBENZYL)OCTANE 1,8 DIAMINE; N 1 (1,2,3,4 TETRAHYDROACRIDIN 9 YL) N 9 (3,4,5 TRIMETHOXYBENZYL)NONANE 1,9 DIAMINE; N 1 (3,4 DIMETHOXYBENZYL) N 6 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)HEXANE 1,6 DIAMINE; N 1 (3,4 DIMETHOXYBENZYL) N 7 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)HEPTANE 1,7 DIAMINE; N 1 (3,4 DIMETHOXYBENZYL) N 8 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)OCTANE 1,8 DIAMINE; N 1 (3,4 DIMETHOXYBENZYL) N 9 (1,2,3,4 TETRAHYDROACRIDIN 9 YL)NONANE 1,9 DIAMINE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR MODEL; PROTEIN AGGREGATION;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; BENZENE; BINDING SITES; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; DRUG DESIGN; KINETICS; PEPTIDE FRAGMENTS; TACRINE;

EID: 78651472058     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.022     Document Type: Article

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