Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1045-1053

  Dillon, Gerald P ^a   Gaynor, Joanne M ^b   Khan, Denise ^a   Carolan, Ciaran G ^a   Ryder, Sheila A ^a   Marquez, Juan F ^a   Reidy, Sean ^b   Gilmer, John F ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Technological University of the Shannon:Midlands Midwest   (Ireland)

Author keywords

Butyrylcholinesterase inhibitor; Metabolic stability; Selectivity

Indexed keywords

2 (BENZYLAMINOCARBONYLOXY) 5 (PHENYLCARBONYLOXYIMINO) 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 DEOXY 5 PHENYLCARBONYLAMINO 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 DEOXY LEVO XYLOHEX 6 ENITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 DEOXY, 5 DEHYDRO[(ETHYLOXYCARBONYL)ENE] 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 KETO 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 KETOXIME 1,4:3,6 DIANHYDRO DEXTRI GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 O (PHENYLPROPYLOXY) 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 2 (BENZYLAMINOCARBONYLOXY) 5 O BENZYL 1,4:3,6 DIANHYDRO DEXTRO GLUCITOL; 7 EXO(BENZYLAMINOCARBONYLOXY) 3 OXO 2,5,9 TRIOXABICYCLO[4.3.0]NONANE; CARBAMIC ACID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ESTER DERIVATIVE; ISOSORBIDE DERIVATIVE; ISOSORBIDE DI(4 CHLOROPHENYLCARBAMATE); ISOSORBIDE DI(4 NITROPHENYL CARBAMATE); ISOSORBIDE DI(BUTYLCARBAMATE); ISOSORBIDE DI(ETHYLCARBAMATE); ISOSORBIDE DI(PROPYLCARBAMATE); ISOSORBIDE DIPHENYLCARBAMATE; N METHYL 7 EXO(BENZYLAMINOCARBONYLOXY) 3 OXO 5,9 DIOXA 2 AZABICYCLO[4.3.0]NONANE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; LIVER HOMOGENATE; MALE; METABOLISM; MOUSE; NONHUMAN; PLASMA;

ALZHEIMER DISEASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; ISOSORBIDE; MICE; MOLECULAR STRUCTURE; PLASMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75149141800     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.052     Document Type: Article

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