Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2232-2244

  Darvesh, Sultan ^a,b   Pottie, Ian R ^b   Darvesh, Katherine V ^b   McDonald, Robert S ^b   Walsh, Ryan ^a   Conrad, Sarah ^b   Penwell, Andrea ^b   Mataija, Diane ^b   Martin, Earl ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b MOUNT SAINT VINCENT UNIVERSITY   (Canada)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Enzyme kinetics; Mutant butyrylcholinesterase

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; MUTANT PROTEIN; PHENOTHIAZINE DERIVATIVE; UREA DERIVATIVE;

ARTICLE; CHOLINESTERASE INHIBITION; CONCENTRATION RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; HUMAN; MICHAELIS MENTEN KINETICS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTATION; PHENOTHIAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 77649235030     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.066     Document Type: Article

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