Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 19, 2007, Pages 6367-6378

  Darvesh, Sultan ^a,b   McDonald, Robert S ^b   Darvesh, Katherine V ^b   Mataija, Diane ^b   Conrad, Sarah ^b   Gomez, Geraldine ^b   Walsh, Ryan ^a   Martin, Earl ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b MOUNT SAINT VINCENT UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Cholinesterase; Molecular modeling; Partition coefficient

Indexed keywords

AROMATIC AMIDE; CHOLINESTERASE; PHENOTHIAZINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; DRUG POTENCY; DRUG SYNTHESIS; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; MOLECULAR MODEL; NEUROTRANSMISSION;

ACETYLCHOLINE; ALZHEIMER DISEASE; AMIDES; AMYLOID; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; NEUROTRANSMITTER AGENTS; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 34547692764     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.060     Document Type: Article

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