Interaction of physostigmine and alfentanil in a human pain model

British Journal of Anaesthesia

Volumn 104, Issue 3, 2010, Pages 359-368

  Wehrfritz, A P ^a   Ihmsen, H ^a   Schmidt, S ^a   Muller C ^a   Filitz, J ^a   Schuttler J ^a   Koppert, W ^b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Experimental; Mechanism; Pain

Indexed keywords

ALFENTANIL; CHOLINESTERASE INHIBITOR; OPIATE; PHYSOSTIGMINE; PLACEBO;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; HUMAN; HYPERALGESIA; MALE; NAUSEA; NORMAL HUMAN; PAIN; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSCUTANEOUS NERVE STIMULATION; VOMITING;

EID: 77249158434     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep372     Document Type: Article

References (32)

1. Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth 2001; 87: 62-72
2. Nguyen NT, Lee SL, Goldman C, et al. Comparison of pulmonary function and postoperative pain after laparoscopic versus open gastric bypass: a randomized trial. J Am Coll Surg 2001; 192: 469-476
3. Tasmuth T, Estlanderb AM, Kalso E. Effect of present pain and mood on the memory of past postoperative pain in women treated surgically for breast cancer. Pain 1996; 68: 343-347
4. Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg 1998; 86: 781-785 (Pubitemid 28177731)
5. Wu CL, Hurley RW, Anderson GF, Herbert R, Rowlingson AJ, Fleisher LA. Effect of postoperative epidural analgesia on morbidity and mortality following surgery in medicare patients. Reg Anesth Pain Med 2004; 29: 525-533
6. Hyllested M, Jones S, Pedersen JL, Kehlet H. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002; 88: 199-214
7. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992; 327: 749-754
8. Schafer AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995; 35: 209-219
9. Hartvig P, Gillberg PG, Gordh T, Jr, Post C. Cholinergic mechanisms in pain and analgesia. Trends Pharmacol Sci 1989; 10 (Suppl.): 75-79
10. Chiari AI, Eisenach JC. Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity. Anesthesiology 1999; 90: 1413-1421
11. Beilin B, Bessler H, Papismedov L, Weinstock M, Shavit Y. Continuous physostigmine combined with morphine-based patient-controlled analgesia in the postoperative period. Acta Anaesthesiol Scand 2005; 49: 78-84
12. Weinstock M, Davidson JT, Rosin AJ, Schnieden H. Effect of physostigmine on morphine-induced postoperative pain and somnolence. Br J Anaesth 1982; 54: 429-434
13. Koppert W, Sittl R, Scheuber K, Alsheimer M, Schmelz M, Schuttler J. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology 2003; 99: 152-159
14. Koppert W, Dern SK, Sittl R, Albrecht S, Schuttler J, Schmelz M. A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology 2001; 95: 395-402
15. Klede M, Handwerker HO, Schmelz M. Central origin of secondary mechanical hyperalgesia. J Neurophysiol 2003; 90: 353-359
16. Schmelz M, Schmid R, Handwerker HO, Torebjork HE. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 2000; 123: 560-571
17. Weidner C, Schmelz M, Schmidt R, Hansson B, Handwerker HO, Torebjork HE. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci 1999; 19: 10184-10190
18. Berenbaum MC. What is synergy? Pharmacol Rev 1989; 41: 93-141
19. Holford NH, Sheiner LB. Kinetics of pharmacologic response. Pharmacol Ther 1982; 16: 143-166
20. Maitre PO, Vozeh S, Heykants J, Thomson DA, Stanski DR. Population pharmacokinetics of alfentanil: the average doseplasma concentration relationship and interindividual variability in patients. Anesthesiology 1987; 66: 3-12
21. Hartvig P, Wiklund L, Lindstrom B. Pharmacokinetics of physostigmine after intravenous, intramuscular and subcutaneous administration in surgical patients. Acta Anaesthesiol Scand 1986; 30: 177-182 (Pubitemid 16162629)
22. Bol CJ, Vogelaar JP, Tang JP, Mandema JW. Quantification of pharmacodynamic interactions between dexmedetomidine and midazolam in the rat. J Pharmacol Exp Ther 2000; 294: 347-355
23. Bonate PL. Pharmacokinetic-Pharmacodynamic Modeling and Simulation. New York, NY: Springer, 2006
24. Koppert W, Wehrfritz A, Korber N, et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain 2004; 108: 148-153
25. Kehlet H, Werner M, Perkins F. Balanced analgesia: what is it and what are its advantages in postoperative pain? Drugs 1999; 58: 793-797
26. Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458-462
27. Tracey KJ. The inflammatory reflex. Nature 2002; 420: 853-859
28. Hallak M, Giacobini E. Relation of brain regional physostigmine concentration to cholinesterase activity and acetylcholine and choline levels in rat. Neurochem Res 1986; 11: 1037-1048
29. Petersson J, Gordh TE, Hartvig P, Wiklund L. A double-blind trial of the analgesic properties of physostigmine in postoperative patients. Acta Anaesthesiol Scand 1986; 30: 283-288
30. Bernardini N, Roza C, Sauer SK, Gomeza J, Wess J, Reeh PW. Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. J Neurosci 2002; 22: RC229
31. Wess J, Duttaroy A, Gomeza J, et al. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci 2003; 72: 2047-2054
32. Fillingim RB, Gear RW. Sex differences in opioid analgesia: clinical and experimental findings. Eur J Pain 2004; 8: 413-425