메뉴 건너뛰기




Volumn 90, Issue 5, 2012, Pages 471-480

Functional primate genomics - Leveraging the medical potential

Author keywords

APOE; Comparative genomics; Evolutionary medicine; LPA; Primates

Indexed keywords

APOLIPOPROTEIN E; GENOMIC DNA;

EID: 84862582072     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0901-4     Document Type: Review
Times cited : (28)

References (108)
  • 2
    • 83755172071 scopus 로고    scopus 로고
    • Evolution. rfsti Darwinian medicine's drawn-out dawn
    • Pennisi E (2011) Evolution. Darwinian medicine's drawn-out dawn. Science 334:1486-1487
    • (2011) Science , vol.334 , pp. 1486-1487
    • Pennisi, E.1
  • 4
    • 76549098614 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: A public choice framework for controlling transmissible and evolving diseases
    • Althouse BM, Bergstrom TC, Bergstrom CT (2010) Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases. Proc Natl Acad Sci U S A 107(Suppl 1):1696-1701
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.SUPPL. 1 , pp. 1696-1701
    • Althouse, B.M.1    Bergstrom, T.C.2    Bergstrom, C.T.3
  • 5
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481:306-313
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 6
    • 77953811255 scopus 로고    scopus 로고
    • New approaches to population stratification in genome-wide association studies
    • Price AL, Zaitlen NA, Reich D, Patterson N (2010) New approaches to population stratification in genome-wide association studies. Nat Rev Genet 11:459-463
    • (2010) Nat Rev Genet , vol.11 , pp. 459-463
    • Price, A.L.1    Zaitlen, N.A.2    Reich, D.3    Patterson, N.4
  • 7
    • 79951640772 scopus 로고    scopus 로고
    • The emergence of human-evolutionary medical genomics
    • Crespi BJ (2011) The emergence of human-evolutionary medical genomics. Evol Appl 4:292-314
    • (2011) Evol Appl , vol.4 , pp. 292-314
    • Crespi, B.J.1
  • 8
    • 71049176982 scopus 로고    scopus 로고
    • Genome 10K: A proposal to obtain whole-genome sequence for 10,000 vertebrate species
    • Genome-10K-Community
    • Genome-10K-Community (2009) Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species. J Hered 100:659-674
    • (2009) J Hered , vol.100 , pp. 659-674
  • 9
    • 80051968181 scopus 로고    scopus 로고
    • Needles in stacks of needles: Finding disease-causal variants in a wealth of genomic data
    • Cooper GM, Shendure J (2011) Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data. Nat Rev Genet 12:628-640
    • (2011) Nat Rev Genet , vol.12 , pp. 628-640
    • Cooper, G.M.1    Shendure, J.2
  • 10
    • 58549117084 scopus 로고    scopus 로고
    • Fundamental concepts in genetics: Genetics and the understanding of selection
    • Hurst LD (2009) Fundamental concepts in genetics: genetics and the understanding of selection. Nat Rev Genet 10:83-93
    • (2009) Nat Rev Genet , vol.10 , pp. 83-93
    • Hurst, L.D.1
  • 12
    • 84862552088 scopus 로고    scopus 로고
    • Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery
    • doi:10.1093/molbev/mss079
    • Dudley JT, Chen R, Sanderford M, Butte AJ, Kumar S (2012) Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery. Mol Biol Evol. doi:10.1093/molbev/mss079
    • (2012) Mol Biol Evol.
    • Dudley, J.T.1    Chen, R.2    Sanderford, M.3    Butte, A.J.4    Kumar, S.5
  • 13
    • 14644390333 scopus 로고    scopus 로고
    • A model of the statistical power of comparative genome sequence analysis
    • Eddy SR (2005) A model of the statistical power of comparative genome sequence analysis. PLoS Biol 3:e10
    • (2005) PLoS Biol , vol.3
    • Eddy, S.R.1
  • 14
    • 78149408021 scopus 로고    scopus 로고
    • Massive turnover of functional sequence in human and other mammalian genomes
    • Meader S, Ponting CP, Lunter G (2010) Massive turnover of functional sequence in human and other mammalian genomes. Genome Res 20:1335-1343
    • (2010) Genome Res , vol.20 , pp. 1335-1343
    • Meader, S.1    Ponting, C.P.2    Lunter, G.3
  • 15
    • 80052723471 scopus 로고    scopus 로고
    • Rapid turnover of functional sequence in human and other genomes
    • Ponting CP, Nellaker C, Meader S (2011) Rapid turnover of functional sequence in human and other genomes. Annu Rev Genomics Hum Genet 12:275-299
    • (2011) Annu Rev Genomics Hum Genet , vol.12 , pp. 275-299
    • Ponting, C.P.1    Nellaker, C.2    Meader, S.3
  • 22
    • 79959519398 scopus 로고    scopus 로고
    • Linking genotypes, phenotypes, and fitness in wild primate populations
    • Bradley BJ, Lawler RR (2011) Linking genotypes, phenotypes, and fitness in wild primate populations. Evol Anthropol 20:104-119
    • (2011) Evol Anthropol , vol.20 , pp. 104-119
    • Bradley, B.J.1    Lawler, R.R.2
  • 23
    • 78650909427 scopus 로고    scopus 로고
    • Limitations of nextgeneration genome sequence assembly
    • Alkan C, Sajjadian S, Eichler EE (2011) Limitations of nextgeneration genome sequence assembly. Nat Methods 8:61-65
    • (2011) Nat Methods , vol.8 , pp. 61-65
    • Alkan, C.1    Sajjadian, S.2    Eichler, E.E.3
  • 24
    • 66049087893 scopus 로고    scopus 로고
    • The difficulty of avoiding false positives in genome scans for natural selection
    • Mallick S, Gnerre S, Muller P, Reich D (2009) The difficulty of avoiding false positives in genome scans for natural selection. Genome Res 19:922-933
    • (2009) Genome Res , vol.19 , pp. 922-933
    • Mallick, S.1    Gnerre, S.2    Muller, P.3    Reich, D.4
  • 27
    • 70350714430 scopus 로고    scopus 로고
    • Phylogenomics of primates and their ancestral populations
    • Siepel A (2009) Phylogenomics of primates and their ancestral populations. Genome Res 19:1929-1941
    • (2009) Genome Res , vol.19 , pp. 1929-1941
    • Siepel, A.1
  • 30
    • 80052013378 scopus 로고    scopus 로고
    • Learning about human population history from ancient and modern genomes
    • Stoneking M, Krause J (2011) Learning about human population history from ancient and modern genomes. Nat Rev Genet 12:603-614
    • (2011) Nat Rev Genet , vol.12 , pp. 603-614
    • Stoneking, M.1    Krause, J.2
  • 32
    • 78649231644 scopus 로고    scopus 로고
    • Origins, evolution, and phenotypic impact of new genes
    • Kaessmann H (2010) Origins, evolution, and phenotypic impact of new genes. Genome Res 20:1313-1326
    • (2010) Genome Res , vol.20 , pp. 1313-1326
    • Kaessmann, H.1
  • 33
    • 78149404797 scopus 로고    scopus 로고
    • Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome
    • Zhang YE, Vibranovski MD, Landback P, Marais GA, Long M (2010) Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome. PLoS Biol 8
    • (2010) PLoS Biol , vol.8
    • Zhang, Y.E.1    Vibranovski, M.D.2    Landback, P.3    Marais, G.A.4    Long, M.5
  • 34
    • 80055025720 scopus 로고    scopus 로고
    • Accelerated recruitment of new brain development genes into the human genome
    • Zhang YE, Landback P, Vibranovski MD, Long M (2011) Accelerated recruitment of new brain development genes into the human genome. PLoS Biol 9:e1001179
    • (2011) PLoS Biol , vol.9
    • Zhang, Y.E.1    Landback, P.2    Vibranovski, M.D.3    Long, M.4
  • 37
    • 0030666211 scopus 로고    scopus 로고
    • Convergent evolution of apolipoprotein(a) in primates and hedgehog
    • Lawn RM, Schwartz K, Patthy L (1997) Convergent evolution of apolipoprotein(a) in primates and hedgehog. Proc Natl Acad Sci U S A 94:11992-11997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11992-11997
    • Lawn, R.M.1    Schwartz, K.2    Patthy, L.3
  • 38
    • 0025835955 scopus 로고
    • Lipoprotein(a): Nonhuman primate models
    • Makino K, Scanu AM (1991) Lipoprotein(a): nonhuman primate models. Lipids 26:679-683
    • (1991) Lipids , vol.26 , pp. 679-683
    • Makino, K.1    Scanu, A.M.2
  • 39
    • 0345550304 scopus 로고    scopus 로고
    • Convergent evolution in primates and an insectivore
    • Boffelli D, Cheng JF, Rubin EM (2004) Convergent evolution in primates and an insectivore. Genomics 83:19-23
    • (2004) Genomics , vol.83 , pp. 19-23
    • Boffelli, D.1    Cheng, J.F.2    Rubin, E.M.3
  • 41
    • 0025969527 scopus 로고
    • Variation in Lp(a) levels and Apo(a) isoform frequencies in 5 baboon subspecies
    • Williamsblangero S, Rainwater DL (1991) Variation in Lp(a) levels and Apo(a) isoform frequencies in 5 baboon subspecies. Hum Biol 63:65-76
    • (1991) Hum Biol , vol.63 , pp. 65-76
    • Williamsblangero, S.1    Rainwater, D.L.2
  • 42
    • 33747813902 scopus 로고    scopus 로고
    • Evolutionary simulations to detect functional lineage-specific genes
    • Dupanloup I, Kaessmann H (2006) Evolutionary simulations to detect functional lineage-specific genes. Bioinformatics 22:1815-1822
    • (2006) Bioinformatics , vol.22 , pp. 1815-1822
    • Dupanloup, I.1    Kaessmann, H.2
  • 44
    • 81755177812 scopus 로고    scopus 로고
    • Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
    • Fumagalli M, Sironi M, Pozzoli U, Ferrer-Admetlla A, Pattini L, Nielsen R (2011) Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet 7:e1002355
    • (2011) PLoS Genet , vol.7
    • Fumagalli, M.1    Sironi, M.2    Pozzoli, U.3    Ferrer-Admetlla, A.4    Pattini, L.5    Nielsen, R.6
  • 45
    • 77951074137 scopus 로고    scopus 로고
    • Plasma lipoproteins are important components of the immune system
    • Han R (2010) Plasma lipoproteins are important components of the immune system. Microbiol Immunol 54:246-253
    • (2010) Microbiol Immunol , vol.54 , pp. 246-253
    • Han, R.1
  • 46
    • 60549101700 scopus 로고    scopus 로고
    • A physiological function for apolipoprotein(a): A natural regulator of the inflammatory response
    • Hoover-Plow J, Hart E, Gong Y, Shchurin A, Schneeman T (2009) A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response. Exp Biol Med (Maywood) 234:28-34
    • (2009) Exp Biol Med (Maywood) , vol.234 , pp. 28-34
    • Hoover-Plow, J.1    Hart, E.2    Gong, Y.3    Shchurin, A.4    Schneeman, T.5
  • 47
    • 0023652132 scopus 로고
    • Plasma lipoproteins: Teaching old dogmas new tricks
    • Brown MS, Goldstein JL (1987) Plasma lipoproteins: teaching old dogmas new tricks. Nature 330:113-114
    • (1987) Nature , vol.330 , pp. 113-114
    • Brown, M.S.1    Goldstein, J.L.2
  • 48
    • 79960642108 scopus 로고    scopus 로고
    • Molecular mechanisms of epistasis within and between genes
    • Lehner B (2011) Molecular mechanisms of epistasis within and between genes. Trends Genet 27:323-331
    • (2011) Trends Genet , vol.27 , pp. 323-331
    • Lehner, B.1
  • 52
    • 78649619650 scopus 로고    scopus 로고
    • Triangulation of the human, chimpanzee, and Neanderthal genome sequences identifies potentially compensated mutations
    • Zhang G, Pei Z, Krawczak M, Ball EV, Mort M, Kehrer-Sawatzki H, Cooper DN (2010) Triangulation of the human, chimpanzee, and Neanderthal genome sequences identifies potentially compensated mutations. Hum Mutat 31:1286-1293
    • (2010) Hum Mutat , vol.31 , pp. 1286-1293
    • Zhang, G.1    Pei, Z.2    Krawczak, M.3    Ball, E.V.4    Mort, M.5    Kehrer-Sawatzki, H.6    Cooper, D.N.7
  • 53
    • 0345293158 scopus 로고    scopus 로고
    • Why are some human disease-associated mutations fixed in mice?
    • Gao L, Zhang J (2003) Why are some human disease-associated mutations fixed in mice? Trends Genet 19:678-681
    • (2003) Trends Genet , vol.19 , pp. 678-681
    • Gao, L.1    Zhang, J.2
  • 54
    • 78650686441 scopus 로고    scopus 로고
    • Apolipoprotein E: From lipid transport to neurobiology
    • Hauser PS, Narayanaswami V, Ryan RO (2011) Apolipoprotein E: from lipid transport to neurobiology. Prog Lipid Res 50:62-74
    • (2011) Prog Lipid Res , vol.50 , pp. 62-74
    • Hauser, P.S.1    Narayanaswami, V.2    Ryan, R.O.3
  • 55
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein e and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • Bu G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10:333-344
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 56
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
    • Mahley RW, Weisgraber KH, Huang Y (2009) Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 50(Suppl):S183-188
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 57
    • 70350448412 scopus 로고    scopus 로고
    • Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function
    • Zhong N, Ramaswamy G, Weisgraber KH (2009) Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J Biol Chem 284:27273-27280
    • (2009) J Biol Chem , vol.284 , pp. 27273-27280
    • Zhong, N.1    Ramaswamy, G.2    Weisgraber, K.H.3
  • 58
  • 60
    • 76549115951 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
    • Finch CE (2010) Evolution in health and medicine Sackler colloquium: evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A 107(Suppl 1):1718-1724
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.SUPPL. 1 , pp. 1718-1724
    • Finch, C.E.1
  • 61
    • 36749056855 scopus 로고    scopus 로고
    • The other side of the nearly neutral theory, evidence of slightly advantageous backmutations
    • Charlesworth J, Eyre-Walker A (2007) The other side of the nearly neutral theory, evidence of slightly advantageous backmutations. Proc Natl Acad Sci U S A 104:16992-16997
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16992-16997
    • Charlesworth, J.1    Eyre-Walker, A.2
  • 62
    • 80052310539 scopus 로고    scopus 로고
    • Evidence for hitchhiking of deleterious mutations within the human genome
    • Chun S, Fay JC (2011) Evidence for hitchhiking of deleterious mutations within the human genome. PLoS Genet 7: e1002240
    • (2011) PLoS Genet , vol.7
    • Chun, S.1    Fay, J.C.2
  • 65
    • 77956315574 scopus 로고    scopus 로고
    • Selection on alleles affecting human longevity and late-life disease: The example of apolipoprotein e
    • Drenos F, Kirkwood TB (2010) Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E. PLoS One 5:e10022
    • (2010) PLoS One , vol.5
    • Drenos, F.1    Kirkwood, T.B.2
  • 66
    • 78751683188 scopus 로고    scopus 로고
    • Linking ecological immunology and evolutionary medicine: The case for apolipoprotein e
    • Trotter JH, Liebl AL, Weeber EJ, Martin LB (2011) Linking ecological immunology and evolutionary medicine: the case for apolipoprotein E. Funct Ecol 25:40-47
    • (2011) Funct Ecol , vol.25 , pp. 40-47
    • Trotter, J.H.1    Liebl, A.L.2    Weeber, E.J.3    Martin, L.B.4
  • 68
    • 79960253200 scopus 로고    scopus 로고
    • FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
    • Enard W (2011) FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution. Curr Opin Neurobiol 21(3):415-424
    • (2011) Curr Opin Neurobiol , vol.21 , Issue.3 , pp. 415-424
    • Enard, W.1
  • 69
    • 76749097550 scopus 로고    scopus 로고
    • The genetics of human adaptation: Hard sweeps, soft sweeps, and polygenic adaptation
    • Pritchard JK, Pickrell JK, Coop G (2010) The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol 20:R208-215
    • (2010) Curr Biol , vol.20
    • Pritchard, J.K.1    Pickrell, J.K.2    Coop, G.3
  • 70
    • 0036196885 scopus 로고    scopus 로고
    • The signature of positive selection at randomly chosen loci
    • Przeworski M (2002) The signature of positive selection at randomly chosen loci. Genetics 160:1179-1189
    • (2002) Genetics , vol.160 , pp. 1179-1189
    • Przeworski, M.1
  • 71
    • 35748983523 scopus 로고    scopus 로고
    • Approaches for identifying targets of positive selection
    • Jensen JD, Wong A, Aquadro CF (2007) Approaches for identifying targets of positive selection. Trends Genet 23:568-577
    • (2007) Trends Genet , vol.23 , pp. 568-577
    • Jensen, J.D.1    Wong, A.2    Aquadro, C.F.3
  • 72
    • 77649263292 scopus 로고    scopus 로고
    • Population genetic inference from genomic sequence variation
    • Pool JE, Hellmann I, Jensen JD, Nielsen R (2010) Population genetic inference from genomic sequence variation. Genome Res 20:291-300
    • (2010) Genome Res , vol.20 , pp. 291-300
    • Pool, J.E.1    Hellmann, I.2    Jensen, J.D.3    Nielsen, R.4
  • 74
    • 65149103048 scopus 로고    scopus 로고
    • Constructing genomic maps of positive selection in humans: Where do we go from here?
    • Akey JM (2009) Constructing genomic maps of positive selection in humans: where do we go from here? Genome Res 19:711-722
    • (2009) Genome Res , vol.19 , pp. 711-722
    • Akey, J.M.1
  • 75
    • 33744815615 scopus 로고    scopus 로고
    • How reliable are empirical genomic scans for selective sweeps?
    • Teshima KM, Coop G, Przeworski M (2006) How reliable are empirical genomic scans for selective sweeps? Genome Res 16:702-712
    • (2006) Genome Res , vol.16 , pp. 702-712
    • Teshima, K.M.1    Coop, G.2    Przeworski, M.3
  • 76
    • 0036245438 scopus 로고    scopus 로고
    • Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
    • Rosenberg NA, Nordborg M (2002) Genealogical trees, coalescent theory and the analysis of genetic polymorphisms. Nat Rev Genet 3:380-390
    • (2002) Nat Rev Genet , vol.3 , pp. 380-390
    • Rosenberg, N.A.1    Nordborg, M.2
  • 77
    • 67149096366 scopus 로고    scopus 로고
    • Widespread genomic signatures of natural selection in hominid evolution
    • McVicker G, Gordon D, Davis C, Green P (2009) Widespread genomic signatures of natural selection in hominid evolution. PLoS Genet 5:e1000471
    • (2009) PLoS Genet , vol.5
    • McVicker, G.1    Gordon, D.2    Davis, C.3    Green, P.4
  • 78
    • 0027305597 scopus 로고
    • The effect of deleterious mutations on neutral molecular variation
    • Charlesworth B, Morgan MT, Charlesworth D (1993) The effect of deleterious mutations on neutral molecular variation. Genetics 134:1289-1303
    • (1993) Genetics , vol.134 , pp. 1289-1303
    • Charlesworth, B.1    Morgan, M.T.2    Charlesworth, D.3
  • 79
    • 79851478724 scopus 로고    scopus 로고
    • Genome-wide association study SNPs in the human genome diversity project populations: Does selection affect unlinked SNPs with shared trait associations?
    • Casto AM, Feldman MW (2011) Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? PLoS Genet 7:e1001266
    • (2011) PLoS Genet , vol.7
    • Casto, A.M.1    Feldman, M.W.2
  • 80
    • 62149112938 scopus 로고    scopus 로고
    • Molecular evolution of the antiretroviral TRIM5 gene
    • Johnson WE, Sawyer SL (2009) Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics 61:163-176
    • (2009) Immunogenetics , vol.61 , pp. 163-176
    • Johnson, W.E.1    Sawyer, S.L.2
  • 81
    • 34250839345 scopus 로고    scopus 로고
    • Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein
    • Kaiser SM, Malik HS, Emerman M (2007) Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. Science 316:1756-1758
    • (2007) Science , vol.316 , pp. 1756-1758
    • Kaiser, S.M.1    Malik, H.S.2    Emerman, M.3
  • 82
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J (2004) The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 427:848-853
    • (2004) Nature , vol.427 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3    Kiessling, M.4    Autissier, P.5    Sodroski, J.6
  • 83
    • 61349112079 scopus 로고    scopus 로고
    • From fitness landscapes to seascapes: Non-equilibrium dynamics of selection and adaptation
    • Mustonen V, Lassig M (2009) From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation. Trends Genet 25:111-119
    • (2009) Trends Genet , vol.25 , pp. 111-119
    • Mustonen, V.1    Lassig, M.2
  • 87
    • 34548488236 scopus 로고    scopus 로고
    • Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for positive selection of MCPH1 and ASPM
    • author reply 1036
    • Timpson N, Heron J, Smith GD, Enard W (2007) Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for positive selection of MCPH1 and ASPM. Science 317:1036, author reply 1036
    • (2007) Science , vol.317 , pp. 1036
    • Timpson, N.1    Heron, J.2    Smith, G.D.3    Enard, W.4
  • 90
    • 84855378129 scopus 로고    scopus 로고
    • NEW: Network-enabled wisdom in biology, medicine, and health care
    • Schadt EE, Bjorkegren JL (2012) NEW: network-enabled wisdom in biology, medicine, and health care. Sci Transl Med 4:115rv111
    • (2012) Sci Transl Med , vol.4
    • Schadt, E.E.1    Bjorkegren, J.L.2
  • 91
    • 80052877875 scopus 로고    scopus 로고
    • Inferring regulatory mechanisms from patterns of evolutionary divergence
    • Tirosh I, Barkai N (2011) Inferring regulatory mechanisms from patterns of evolutionary divergence. Mol Syst Biol 7:530
    • (2011) Mol Syst Biol , vol.7 , pp. 530
    • Tirosh, I.1    Barkai, N.2
  • 94
    • 78650485698 scopus 로고    scopus 로고
    • Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates
    • Montgomery SH, Capellini I, Venditti C, Barton RA, Mundy NI (2011) Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates. Mol Biol Evol 28:625-638
    • (2011) Mol Biol Evol , vol.28 , pp. 625-638
    • Montgomery, S.H.1    Capellini, I.2    Venditti, C.3    Barton, R.A.4    Mundy, N.I.5
  • 95
    • 66349111794 scopus 로고    scopus 로고
    • Genotype-phenotype associations: Substitution models to detect evolutionary associations between phenotypic variables and genotypic evolutionary rate
    • O'Connor TD, Mundy NI (2009) Genotype-phenotype associations: substitution models to detect evolutionary associations between phenotypic variables and genotypic evolutionary rate. Bioinformatics 25:i94-100
    • (2009) Bioinformatics , vol.25
    • O'connor, T.D.1    Mundy, N.I.2
  • 96
    • 9644287861 scopus 로고    scopus 로고
    • Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
    • Dorus S, Evans PD, Wyckoff GJ, Choi SS, Lahn BT (2004) Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat Genet 36:1326-1329
    • (2004) Nat Genet , vol.36 , pp. 1326-1329
    • Dorus, S.1    Evans, P.D.2    Wyckoff, G.J.3    Choi, S.S.4    Lahn, B.T.5
  • 97
    • 77955264860 scopus 로고    scopus 로고
    • Promiscuity and the rate of molecular evolution at primate immunity genes
    • Wlasiuk G, Nachman MW (2010) Promiscuity and the rate of molecular evolution at primate immunity genes. Evolution 64:2204-2220
    • (2010) Evolution , vol.64 , pp. 2204-2220
    • Wlasiuk, G.1    Nachman, M.W.2
  • 98
    • 84055216956 scopus 로고    scopus 로고
    • Rationale and design of the Leipzig (LIFE) Heart Study: Phenotyping and cardiovascular characteristics of patients with coronary artery disease
    • Beutner F, Teupser D, Gielen S, Holdt LM, Scholz M, Boudriot E, Schuler G, Thiery J (2011) Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease. PLoS One 6: e29070
    • (2011) PLoS One , vol.6
    • Beutner, F.1    Teupser, D.2    Gielen, S.3    Holdt, L.M.4    Scholz, M.5    Boudriot, E.6    Schuler, G.7    Thiery, J.8
  • 102
  • 103
    • 84859541449 scopus 로고    scopus 로고
    • Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
    • doi:10.1101/gr.127324.111
    • Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y et al (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res 22(4):611-622. doi:10.1101/gr.127324.111
    • (2012) Genome Res , vol.22 , Issue.4 , pp. 611-622
    • Liu, X.1    Somel, M.2    Tang, L.3    Yan, Z.4    Jiang, X.5    Guo, S.6    Yuan, Y.7    He, L.8    Oleksiak, A.9    Zhang, Y.10
  • 104
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy
    • Robinton DA, Daley GQ (2012) The promise of induced pluripotent stem cells in research and therapy. Nature 481:295-305
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 107
    • 84856430123 scopus 로고    scopus 로고
    • Gene editing: Not just for translation anymore
    • McMahon MA, Rahdar M, Porteus M (2012) Gene editing: not just for translation anymore. Nat Methods 9:28-31
    • (2012) Nat Methods , vol.9 , pp. 28-31
    • McMahon, M.A.1    Rahdar, M.2    Porteus, M.3
  • 108
    • 67649204837 scopus 로고    scopus 로고
    • The seven deadly sins of comparative analysis
    • Freckleton RP (2009) The seven deadly sins of comparative analysis. J Evol Biol 22:1367-1375
    • (2009) J Evol Biol , vol.22 , pp. 1367-1375
    • Freckleton, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.